TY - JOUR
T1 - Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways.
AU - Brandelius, Angelica
AU - Andersson, Morgan
AU - Uller, Lena
PY - 2014
Y1 - 2014
N2 - Airway challenge with dsRNA is of interest since this agent acts on TLR3 and mimics rhinoviral (RV) infection-induced interferons/cytokines. Contrasting frequent employment of dsRNA in epithelial cell cultures there is no information on effects of dsRNA administered to human airways in vivo. Here we explore effects of nasal dsRNA challenges in subjects with seasonal allergic rhinitis inside and outside Swedish birch pollen season.
AB - Airway challenge with dsRNA is of interest since this agent acts on TLR3 and mimics rhinoviral (RV) infection-induced interferons/cytokines. Contrasting frequent employment of dsRNA in epithelial cell cultures there is no information on effects of dsRNA administered to human airways in vivo. Here we explore effects of nasal dsRNA challenges in subjects with seasonal allergic rhinitis inside and outside Swedish birch pollen season.
U2 - 10.1016/j.rmed.2014.10.010
DO - 10.1016/j.rmed.2014.10.010
M3 - Article
C2 - 25456711
VL - 108
SP - 1816
EP - 1819
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 1532-3064
IS - 12
ER -