TY - JOUR
T1 - Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk
T2 - Results from the EPIC cohort study
AU - Sanikini, Harinakshi
AU - Dik, Vincent K.
AU - Siersema, Peter D.
AU - Bhoo-Pathy, Nirmala
AU - Uiterwaal, Cuno S P M
AU - Peeters, Petra H M
AU - González, Carlos A.
AU - Zamora-Ros, Raul
AU - Overvad, Kim
AU - Tjønneland, Anne
AU - Roswall, Nina
AU - Boutron-Ruault, Marie Christine
AU - Fagherazzi, Guy
AU - Racine, Antoine
AU - Kühn, Tilman
AU - Katzke, Verena
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Trichopoulos, Dimitrios
AU - Lagiou, Pagona
AU - Palli, Domenico
AU - Grioni, Sara
AU - Vineis, Paolo
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Weiderpass, Elisabete
AU - Skeie, Guri
AU - Braaten, Tonje
AU - Huerta, José Maŕa
AU - Sánchez-Cantalejo, Emilio
AU - Barricarte, Aurelio
AU - Sonestedt, Emily
AU - Wallstrom, Peter
AU - Nilsson, Lena Maria
AU - Johansson, Ingegerd
AU - Bradbury, Kathryn E.
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Huybrechts, Inge
AU - Freisling, Heinz
AU - Cross, Amanda J.
AU - Riboli, Elio
AU - Bueno-de-Mesquita, H. B.
PY - 2015/3/15
Y1 - 2015/3/15
N2 - Prospective studies examining the association between coffee and tea consumption and gastric cancer risk have shown inconsistent results. We investigated the association between coffee (total, caffeinated and decaffeinated) and tea consumption and the risk of gastric cancer by anatomical site and histological type in the European Prospective Investigation into Cancer and Nutrition study. Coffee and tea consumption were assessed by dietary questionnaires at baseline. Adjusted hazard ratios (HRs) were calculated using Cox regression models. During 11.6 years of follow up, 683 gastric adenocarcinoma cases were identified among 477,312 participants. We found no significant association between overall gastric cancer risk and consumption of total coffee (HR 1.09, 95%-confidence intervals [CI]: 0.84-1.43; quartile 4 vs. non/quartile 1), caffeinated coffee (HR 1.14, 95%-CI: 0.82-1.59; quartile 4 vs. non/quartile 1), decaffeinated coffee (HR 1.07, 95%-CI: 0.75-1.53; tertile 3 vs. non/tertile 1) and tea (HR 0.81, 95%-CI: 0.59-1.09; quartile 4 vs. non/quartile 1). When stratified by anatomical site, we observed a significant positive association between gastric cardia cancer risk and total coffee consumption per increment of 100 mL/day (HR 1.06, 95%-CI: 1.03-1.11). Similarly, a significant positive association was observed between gastric cardia cancer risk and caffeinated coffee consumption (HR 1.98, 95%-CI: 1.16-3.36, p-trend=0.06; quartile 3 vs. non/quartile 1) and per increment of 100 mL/day (HR 1.09, 95%-CI: 1.04-1.14). In conclusion, consumption of total, caffeinated and decaffeinated coffee and tea is not associated with overall gastric cancer risk. However, total and caffeinated coffee consumption may be associated with an increased risk of gastric cardia cancer. Further prospective studies are needed to rule out chance or confounding.
AB - Prospective studies examining the association between coffee and tea consumption and gastric cancer risk have shown inconsistent results. We investigated the association between coffee (total, caffeinated and decaffeinated) and tea consumption and the risk of gastric cancer by anatomical site and histological type in the European Prospective Investigation into Cancer and Nutrition study. Coffee and tea consumption were assessed by dietary questionnaires at baseline. Adjusted hazard ratios (HRs) were calculated using Cox regression models. During 11.6 years of follow up, 683 gastric adenocarcinoma cases were identified among 477,312 participants. We found no significant association between overall gastric cancer risk and consumption of total coffee (HR 1.09, 95%-confidence intervals [CI]: 0.84-1.43; quartile 4 vs. non/quartile 1), caffeinated coffee (HR 1.14, 95%-CI: 0.82-1.59; quartile 4 vs. non/quartile 1), decaffeinated coffee (HR 1.07, 95%-CI: 0.75-1.53; tertile 3 vs. non/tertile 1) and tea (HR 0.81, 95%-CI: 0.59-1.09; quartile 4 vs. non/quartile 1). When stratified by anatomical site, we observed a significant positive association between gastric cardia cancer risk and total coffee consumption per increment of 100 mL/day (HR 1.06, 95%-CI: 1.03-1.11). Similarly, a significant positive association was observed between gastric cardia cancer risk and caffeinated coffee consumption (HR 1.98, 95%-CI: 1.16-3.36, p-trend=0.06; quartile 3 vs. non/quartile 1) and per increment of 100 mL/day (HR 1.09, 95%-CI: 1.04-1.14). In conclusion, consumption of total, caffeinated and decaffeinated coffee and tea is not associated with overall gastric cancer risk. However, total and caffeinated coffee consumption may be associated with an increased risk of gastric cardia cancer. Further prospective studies are needed to rule out chance or confounding.
KW - Caffeinated coffee
KW - Coffee
KW - Decaffeinated coffee
KW - European prospective investigation into cancer and nutrition
KW - Gastric cancer
KW - Tea
UR - http://www.scopus.com/inward/record.url?scp=84961289846&partnerID=8YFLogxK
U2 - 10.1002/ijc.29223
DO - 10.1002/ijc.29223
M3 - Article
C2 - 25236393
AN - SCOPUS:84961289846
SN - 0020-7136
VL - 136
SP - E720-E730
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 6
ER -
