TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia

Norafiza Zainuddin; Fiona Murray; Meena Kanduri; Rebeqa Gunnarsson; Karin E. Smedby; Gunilla Enblad; Jesper Jurlander; Gunnar Juliusson; Richard Rosenquist

doi:10.1016/j.leukres.2010.08.023

TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia

Norafiza Zainuddin, Fiona Murray, Meena Kanduri, Rebeqa Gunnarsson, Karin E. Smedby, Gunilla Enblad, Jesper Jurlander, Gunnar Juliusson, Richard Rosenquist

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Abstract

TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	272-274
Journal	Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/j.leukres.2010.08.023
Publication status	Published - 2011

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Hematology/Transplantation (013022014)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

TP53 mutation
17p-deletion
Prognosis
Chronic lymphocytic leukemia

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10.1016/j.leukres.2010.08.023

Elsevier__Zainuddin_et_al

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title = "TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia",

abstract = "TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7\% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1\%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6\%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved.",

keywords = "TP53 mutation, 17p-deletion, Prognosis, Chronic lymphocytic leukemia",

author = "Norafiza Zainuddin and Fiona Murray and Meena Kanduri and Rebeqa Gunnarsson and Smedby, \{Karin E.\} and Gunilla Enblad and Jesper Jurlander and Gunnar Juliusson and Richard Rosenquist",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematology/Transplantation (013022014)",

year = "2011",

doi = "10.1016/j.leukres.2010.08.023",

language = "English",

volume = "35",

pages = "272--274",

journal = "Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis",

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TY - JOUR

T1 - TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia

AU - Zainuddin, Norafiza

AU - Murray, Fiona

AU - Kanduri, Meena

AU - Gunnarsson, Rebeqa

AU - Smedby, Karin E.

AU - Enblad, Gunilla

AU - Jurlander, Jesper

AU - Juliusson, Gunnar

AU - Rosenquist, Richard

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematology/Transplantation (013022014)

PY - 2011

Y1 - 2011

N2 - TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved.

AB - TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved.

KW - TP53 mutation

KW - 17p-deletion

KW - Prognosis

KW - Chronic lymphocytic leukemia

UR - https://www.scopus.com/pages/publications/78751702338

U2 - 10.1016/j.leukres.2010.08.023

DO - 10.1016/j.leukres.2010.08.023

M3 - Article

C2 - 20870288

SN - 1873-5835

VL - 35

SP - 272

EP - 274

JO - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

JF - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

IS - 2

ER -

TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia

Abstract

Bibliographical note

UN SDGs

Subject classification (UKÄ)

Free keywords

Access to Document

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Cite this