Transcriptional profiling of human dendritic cell populations and models - unique profiles of in vitro dendritic cells and implications on functionality and applicability.

Kristina Lundberg; Ann-Sofie Albrekt; Inge Nelissen; Saskia Santegoets; Tanja D de Gruijl; Sue Gibbs; Malin Lindstedt

doi:10.1371/journal.pone.0052875

Transcriptional profiling of human dendritic cell populations and models - unique profiles of in vitro dendritic cells and implications on functionality and applicability.

Kristina Lundberg, Ann-Sofie Albrekt, Inge Nelissen, Saskia Santegoets, Tanja D de Gruijl, Sue Gibbs, Malin Lindstedt

Department of Immunotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

Dendritic cells (DCs) comprise heterogeneous populations of cells, which act as central orchestrators of the immune response. Applicability of primary DCs is restricted due to their scarcity and therefore DC models are commonly employed in DC-based immunotherapy strategies and in vitro tests assessing DC function. However, the interrelationship between the individual in vitro DC models and their relative resemblance to specific primary DC populations remain elusive.

Original language	English
Article number	e52875
Journal	PLoS ONE
Volume	8
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0052875
Publication status	Published - 2013

Subject classification (UKÄ)

Immunology in the medical area

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10.1371/journal.pone.0052875

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title = "Transcriptional profiling of human dendritic cell populations and models - unique profiles of in vitro dendritic cells and implications on functionality and applicability.",

abstract = "Dendritic cells (DCs) comprise heterogeneous populations of cells, which act as central orchestrators of the immune response. Applicability of primary DCs is restricted due to their scarcity and therefore DC models are commonly employed in DC-based immunotherapy strategies and in vitro tests assessing DC function. However, the interrelationship between the individual in vitro DC models and their relative resemblance to specific primary DC populations remain elusive.",

author = "Kristina Lundberg and Ann-Sofie Albrekt and Inge Nelissen and Saskia Santegoets and {de Gruijl}, {Tanja D} and Sue Gibbs and Malin Lindstedt",

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AU - Lundberg, Kristina

AU - Albrekt, Ann-Sofie

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AU - Santegoets, Saskia

AU - de Gruijl, Tanja D

AU - Gibbs, Sue

AU - Lindstedt, Malin

PY - 2013

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AB - Dendritic cells (DCs) comprise heterogeneous populations of cells, which act as central orchestrators of the immune response. Applicability of primary DCs is restricted due to their scarcity and therefore DC models are commonly employed in DC-based immunotherapy strategies and in vitro tests assessing DC function. However, the interrelationship between the individual in vitro DC models and their relative resemblance to specific primary DC populations remain elusive.

U2 - 10.1371/journal.pone.0052875

DO - 10.1371/journal.pone.0052875

M3 - Article

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SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 1

M1 - e52875

ER -

Transcriptional profiling of human dendritic cell populations and models - unique profiles of in vitro dendritic cells and implications on functionality and applicability.

Abstract

Subject classification (UKÄ)

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