Transfer RNA modifications and modifying enzymes in Saccharomyces cerevisiae

Marcus J.O. Johansson; Anders S. Byström

doi:10.1007/b105814

Transfer RNA modifications and modifying enzymes in Saccharomyces cerevisiae

Marcus J.O. Johansson, Anders S. Byström

Umeå University

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Abstract

Transfer RNAs are adaptor molecules, which decode mRNA into protein and,
thereby, play a central role in gene expression. During the maturation of a primary
tRNA transcript, specific subsets of the four normal nucleosides adenosine,
cytidine, guanosine, and uridine are modified. The formation of a modified nucleoside
can require more than one gene product and may involve several enzymatic
steps. In the last few years, the identification of gene products required for
formation of modified nucleosides in tRNA has dramatically increased. In this review,
proteins involved in modification of cytoplasmic tRNAs in Saccharomyces
cerevisiae are described, emphasizing phenotypic characteristics of modification
deficient strains and genetic approaches used to determine the in vivo role of
modified nucleosides/ modifying enzymes.

Original language	English
Title of host publication	Fine-Tuning of RNA Functions by Modification and Editing
Editors	Henri Grosjean
Pages	87-120
Volume	12
ISBN (Electronic)	978-3-540-31454-7
DOIs	https://doi.org/10.1007/b105814
Publication status	Published - 2005 Jan 7
Externally published	Yes

Publication series

Name	Topics in Current Genetics
Volume	12
ISSN (Print)	1610-2096
ISSN (Electronic)	1610-6970

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10.1007/b105814

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abstract = "Transfer RNAs are adaptor molecules, which decode mRNA into protein and,thereby, play a central role in gene expression. During the maturation of a primarytRNA transcript, specific subsets of the four normal nucleosides adenosine,cytidine, guanosine, and uridine are modified. The formation of a modified nucleosidecan require more than one gene product and may involve several enzymaticsteps. In the last few years, the identification of gene products required forformation of modified nucleosides in tRNA has dramatically increased. In this review,proteins involved in modification of cytoplasmic tRNAs in Saccharomycescerevisiae are described, emphasizing phenotypic characteristics of modificationdeficient strains and genetic approaches used to determine the in vivo role ofmodified nucleosides/ modifying enzymes.",

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doi = "10.1007/b105814",

language = "English",

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Transfer RNA modifications and modifying enzymes in Saccharomyces cerevisiae. / Johansson, Marcus J.O.; Byström, Anders S.
Fine-Tuning of RNA Functions by Modification and Editing . ed. / Henri Grosjean. Vol. 12 2005. p. 87-120 (Topics in Current Genetics; Vol. 12).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

TY - CHAP

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AU - Johansson, Marcus J.O.

AU - Byström, Anders S.

PY - 2005/1/7

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N2 - Transfer RNAs are adaptor molecules, which decode mRNA into protein and,thereby, play a central role in gene expression. During the maturation of a primarytRNA transcript, specific subsets of the four normal nucleosides adenosine,cytidine, guanosine, and uridine are modified. The formation of a modified nucleosidecan require more than one gene product and may involve several enzymaticsteps. In the last few years, the identification of gene products required forformation of modified nucleosides in tRNA has dramatically increased. In this review,proteins involved in modification of cytoplasmic tRNAs in Saccharomycescerevisiae are described, emphasizing phenotypic characteristics of modificationdeficient strains and genetic approaches used to determine the in vivo role ofmodified nucleosides/ modifying enzymes.

AB - Transfer RNAs are adaptor molecules, which decode mRNA into protein and,thereby, play a central role in gene expression. During the maturation of a primarytRNA transcript, specific subsets of the four normal nucleosides adenosine,cytidine, guanosine, and uridine are modified. The formation of a modified nucleosidecan require more than one gene product and may involve several enzymaticsteps. In the last few years, the identification of gene products required forformation of modified nucleosides in tRNA has dramatically increased. In this review,proteins involved in modification of cytoplasmic tRNAs in Saccharomycescerevisiae are described, emphasizing phenotypic characteristics of modificationdeficient strains and genetic approaches used to determine the in vivo role ofmodified nucleosides/ modifying enzymes.

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BT - Fine-Tuning of RNA Functions by Modification and Editing

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Transfer RNA modifications and modifying enzymes in Saccharomyces cerevisiae

Abstract

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