Transient synovitis of the hip in the child: Increased levels of proteoglycan fragments in joint fluid

Research output: Contribution to journalArticlepeer-review

Abstract

The levels of proteoglycan antigen were measured in joint aspirates from the hip of children with transient synovitis, septic arthritis, Legg-Calve-Perthes' disease and congenital and traumatic dislocation. Significantly increased levels were found in children with transient synovitis and septic arthritis as compared with other conditions. We propose that the proteoglycan antigens in the joint fluid were released form the articular cartilage in a partially degraded from as a result of an increased rate of proteolytic degradation. In transient synovitis, the source of proteolytic activity may be chondrocytes activated by factors released by synovial cells. The release of joint proteoglycan may cause a temporary increase in deformability of the hip cartilage of the child that could be an important pathogenetic mechanism in some of the sequelae of these diseases.

Original languageEnglish
Pages (from-to)420-424
Number of pages5
JournalJournal of Orthopaedic Research
Volume6
Issue number3
Publication statusPublished - 1988

Subject classification (UKÄ)

  • Orthopedics

Keywords

  • child
  • hip
  • Transient synovitis

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