Translocation-related sarcomas.

Fredrik Mertens, Cristina R Antonescu, Peter Hohenberger, Marc Ladanyi, Piergiorgio Modena, Maurizio D'Incalci, Paolo G Casali, Massimo Aglietta, Thor Alvegård

Research output: Contribution to journalArticlepeer-review

56 Citations (SciVal)

Abstract

Sarcomas with chromosomal translocations represent only about one fourth of sarcoma diagnoses. However, like gastrointestinal stromal tumor (GIST), with its characteristic KIT or PDGFRA mutations, they are particularly interesting since they provide specific biological insights and mechanisms of action that may have an impact upon prognosis or therapy. These are mechanisms we are just beginning to exploit. In this section we will review the biology and clinical impact of translocation-associated sarcomas and review the clinical findings that have made a recent impact upon patients with these diverse diagnoses.
Original languageEnglish
Pages (from-to)312-323
JournalSeminars in Oncology
Volume36
Issue number4
DOIs
Publication statusPublished - 2009

Subject classification (UKÄ)

  • Cancer and Oncology
  • Medical Genetics

Fingerprint

Dive into the research topics of 'Translocation-related sarcomas.'. Together they form a unique fingerprint.

Cite this