Research output per year
Research output per year
Ivan Limachi, Mariela Gonzalez-Ramirez, Sophie Manner, Juan C. Ticona, Efrain Salamanca, Alberto Gimenez, Olov Sterner
Research output: Contribution to journal › Article › peer-review
The fractionation of an ethanol extract of the bark of Trichilia adolfi yielded four novel limonoids (trichilinones A-D, 1-4), with five fused rings and related to the hortiolide-type limonoids. Starting with an ε-lactone, which is α,β-unsaturated in trichilinones A and D (1 and 4), attached to a tetrahydrofuran ring that is connected to an unusual bicyclo [5.1.0] hexane system, joined with a cyclopentanone with a 3-furanyl substituent [(2-oxo)-furan-(5H)-3-yl in trichilinone D (4)], the four compounds isolated display a new 7/5/3/5/5 limonoid ring system. Their structures were established based on extensive analysis of NMR spectroscopic data. As the crude extract possessed anti-leishmanial properties, the compounds were assayed for cytotoxic and anti-parasitic activities in vitro in murine macrophages cells (Raw 264.7) and leishmania promastigotes (L. amazoniensis and L. braziliensis), respectively. The compounds showed moderate cytotoxicity (approximately 70 μg/mL), but are not responsible for the leishmanicidal effect of the extract.
Original language | English |
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Article number | 1019 |
Journal | Molecules (Basel, Switzerland) |
Volume | 26 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2021 |
Research output: Thesis › Doctoral Thesis (compilation)
Research output: Thesis › Doctoral Thesis (compilation)