Tridemethylisovelleral, a potent cytotoxic agent

Isabelle Aujard; Daniel Röme; Erwan Arzel; Martin H Johansson; D de Vos; Olov Sterner

doi:10.1016/j.bmc.2005.06.035

Tridemethylisovelleral, a potent cytotoxic agent

Isabelle Aujard, Daniel Röme, Erwan Arzel, Martin H Johansson, D de Vos, Olov Sterner

Centre for Analysis and Synthesis

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaidehyde system but lacking the three methyl groups, is reported. The cytotoxicity of tridemethylisovelleral toward several tumor cell lines was found to be comparable with those of established antitumor drugs, and significantly higher than that of isovelleral. (c) 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	6145-6150
Journal	Bioorganic & Medicinal Chemistry
Volume	13
Issue number	22
DOIs	https://doi.org/10.1016/j.bmc.2005.06.035
Publication status	Published - 2005

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

Subject classification (UKÄ)

Organic Chemistry

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10.1016/j.bmc.2005.06.035

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title = "Tridemethylisovelleral, a potent cytotoxic agent",

abstract = "The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaidehyde system but lacking the three methyl groups, is reported. The cytotoxicity of tridemethylisovelleral toward several tumor cell lines was found to be comparable with those of established antitumor drugs, and significantly higher than that of isovelleral. (c) 2005 Elsevier Ltd. All rights reserved.",

author = "Isabelle Aujard and Daniel R{\"o}me and Erwan Arzel and Johansson, {Martin H} and {de Vos}, D and Olov Sterner",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)",

year = "2005",

doi = "10.1016/j.bmc.2005.06.035",

language = "English",

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T1 - Tridemethylisovelleral, a potent cytotoxic agent

AU - Aujard, Isabelle

AU - Röme, Daniel

AU - Arzel, Erwan

AU - Johansson, Martin H

AU - de Vos, D

AU - Sterner, Olov

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

PY - 2005

Y1 - 2005

N2 - The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaidehyde system but lacking the three methyl groups, is reported. The cytotoxicity of tridemethylisovelleral toward several tumor cell lines was found to be comparable with those of established antitumor drugs, and significantly higher than that of isovelleral. (c) 2005 Elsevier Ltd. All rights reserved.

AB - The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaidehyde system but lacking the three methyl groups, is reported. The cytotoxicity of tridemethylisovelleral toward several tumor cell lines was found to be comparable with those of established antitumor drugs, and significantly higher than that of isovelleral. (c) 2005 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.bmc.2005.06.035

DO - 10.1016/j.bmc.2005.06.035

M3 - Article

SN - 0968-0896

VL - 13

SP - 6145

EP - 6150

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

IS - 22

ER -

Tridemethylisovelleral, a potent cytotoxic agent

Abstract

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