TY - JOUR
T1 - Truncated somatostatin receptor 5 may modulate therapy response to somatostatin analogues - Observations in two patients with acromegaly and severe headache.
AU - Marina, Djordje
AU - Burman, Pia
AU - Klose, Marianne
AU - Casar-Borota, Olivera
AU - Luque, Raúl M
AU - Castaño, Justo P
AU - Feldt-Rasmussen, Ulla
PY - 2015
Y1 - 2015
N2 - Somatotropinomas have unique "fingerprints" of somatostatin receptor (sst) expression, which are targets in treatment of acromegaly with somatostatin analogues (SSAs). However, a significant expression of sst is not always related to the biochemical response to SSAs. Headache is a common complaint in acromegaly and considered a clinical marker of disease activity. SSAs are reported to have an own analgesic effect, but the sst involved are unknown.
AB - Somatotropinomas have unique "fingerprints" of somatostatin receptor (sst) expression, which are targets in treatment of acromegaly with somatostatin analogues (SSAs). However, a significant expression of sst is not always related to the biochemical response to SSAs. Headache is a common complaint in acromegaly and considered a clinical marker of disease activity. SSAs are reported to have an own analgesic effect, but the sst involved are unknown.
U2 - 10.1016/j.ghir.2015.07.003
DO - 10.1016/j.ghir.2015.07.003
M3 - Article
C2 - 26188991
SN - 1532-2238
VL - 25
SP - 262
EP - 267
JO - Growth Hormone and IGF Research
JF - Growth Hormone and IGF Research
IS - 5
ER -