Tumour microvessel density as predictor of chemotherapy response in breast cancer patients

O Tynninen; J Sjostrom; K von Boguslawski; NO Bengtsson; R Heikkila; Per Malmström; B Ostenstad; E Wist; V Valvere; E Saksela; T Paavonen; C Blomqvist

doi:10.1038/sj.bjc.6600325

Tumour microvessel density as predictor of chemotherapy response in breast cancer patients

O Tynninen, J Sjostrom, K von Boguslawski, NO Bengtsson, R Heikkila, Per Malmström, B Ostenstad, E Wist, V Valvere, E Saksela, T Paavonen, C Blomqvist

Breastcancer-genetics

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer.

Original language	English
Pages (from-to)	1905-1908
Journal	British Journal of Cancer
Volume	86
Issue number	12
DOIs	https://doi.org/10.1038/sj.bjc.6600325
Publication status	Published - 2002

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

metastatic breast cancer
microvessel density
chemotherapy
predictive
factor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6600325

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title = "Tumour microvessel density as predictor of chemotherapy response in breast cancer patients",

abstract = "The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer.",

keywords = "metastatic breast cancer, microvessel density, chemotherapy, predictive, factor",

author = "O Tynninen and J Sjostrom and {von Boguslawski}, K and NO Bengtsson and R Heikkila and Per Malmstr{\"o}m and B Ostenstad and E Wist and V Valvere and E Saksela and T Paavonen and C Blomqvist",

year = "2002",

doi = "10.1038/sj.bjc.6600325",

language = "English",

volume = "86",

pages = "1905--1908",

journal = "British Journal of Cancer",

issn = "1532-1827",

publisher = "Nature Publishing Group",

number = "12",

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TY - JOUR

T1 - Tumour microvessel density as predictor of chemotherapy response in breast cancer patients

AU - Tynninen, O

AU - Sjostrom, J

AU - von Boguslawski, K

AU - Bengtsson, NO

AU - Heikkila, R

AU - Malmström, Per

AU - Ostenstad, B

AU - Wist, E

AU - Valvere, V

AU - Saksela, E

AU - Paavonen, T

AU - Blomqvist, C

PY - 2002

Y1 - 2002

N2 - The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer.

AB - The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer.

KW - metastatic breast cancer

KW - microvessel density

KW - chemotherapy

KW - predictive

KW - factor

U2 - 10.1038/sj.bjc.6600325

DO - 10.1038/sj.bjc.6600325

M3 - Article

SN - 1532-1827

VL - 86

SP - 1905

EP - 1908

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 12

ER -

Tumour microvessel density as predictor of chemotherapy response in breast cancer patients

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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Cite this