Twelve-Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke.

Hayato Tada; Dov Shiffman; Gustav Smith; Marketa Sjögren; Steven A Lubitz; Patrick T Ellinor; Judy Z Louie; Joseph J Catanese; Gunnar Engström; James J Devlin; Sekar Kathiresan; Olle Melander

doi:10.1161/STROKEAHA.114.006072

Twelve-Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke.

Hayato Tada, Dov Shiffman, Gustav Smith, Marketa Sjögren, Steven A Lubitz, Patrick T Ellinor, Judy Z Louie, Joseph J Catanese, Gunnar Engström, James J Devlin, Sekar Kathiresan, Olle Melander

Research output: Contribution to journal › Article › peer-review

Abstract

Atrial fibrillation (AF) is prevalent and there is a clinical need for biomarkers to identify individuals at higher risk for AF. Fixed throughout a life course and assayable early in life, genetic biomarkers may meet this need. Here, we investigate whether multiple single nucleotide polymorphisms together as an AF genetic risk score (AF-GRS) can improve prediction of one's risk for AF.

Original language	English
Pages (from-to)	2856
Journal	Stroke: a journal of cerebral circulation
Volume	45
Issue number	10
DOIs	https://doi.org/10.1161/STROKEAHA.114.006072
Publication status	Published - 2014

Subject classification (UKÄ)

Neurology

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10.1161/STROKEAHA.114.006072

http://www.ncbi.nlm.nih.gov/pubmed/25123217?dopt=Abstract

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Tada, H., Shiffman, D., Smith, G., Sjögren, M., Lubitz, S. A., Ellinor, P. T., Louie, J. Z., Catanese, J. J., Engström, G., Devlin, J. J., Kathiresan, S., & Melander, O. (2014). Twelve-Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke. Stroke: a journal of cerebral circulation, 45(10), 2856. https://doi.org/10.1161/STROKEAHA.114.006072

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title = "Twelve-Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke.",

abstract = "Atrial fibrillation (AF) is prevalent and there is a clinical need for biomarkers to identify individuals at higher risk for AF. Fixed throughout a life course and assayable early in life, genetic biomarkers may meet this need. Here, we investigate whether multiple single nucleotide polymorphisms together as an AF genetic risk score (AF-GRS) can improve prediction of one's risk for AF.",

author = "Hayato Tada and Dov Shiffman and Gustav Smith and Marketa Sj{\"o}gren and Lubitz, {Steven A} and Ellinor, {Patrick T} and Louie, {Judy Z} and Catanese, {Joseph J} and Gunnar Engstr{\"o}m and Devlin, {James J} and Sekar Kathiresan and Olle Melander",

year = "2014",

doi = "10.1161/STROKEAHA.114.006072",

language = "English",

volume = "45",

pages = "2856",

journal = "Stroke: a journal of cerebral circulation",

issn = "1524-4628",

publisher = "American Heart Association",

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Tada, H, Shiffman, D, Smith, G , Sjögren, M, Lubitz, SA, Ellinor, PT, Louie, JZ, Catanese, JJ, Engström, G, Devlin, JJ, Kathiresan, S & Melander, O 2014, 'Twelve-Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke.', Stroke: a journal of cerebral circulation, vol. 45, no. 10, pp. 2856. https://doi.org/10.1161/STROKEAHA.114.006072

TY - JOUR

T1 - Twelve-Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke.

AU - Tada, Hayato

AU - Shiffman, Dov

AU - Smith, Gustav

AU - Sjögren, Marketa

AU - Lubitz, Steven A

AU - Ellinor, Patrick T

AU - Louie, Judy Z

AU - Catanese, Joseph J

AU - Engström, Gunnar

AU - Devlin, James J

AU - Kathiresan, Sekar

AU - Melander, Olle

PY - 2014

Y1 - 2014

N2 - Atrial fibrillation (AF) is prevalent and there is a clinical need for biomarkers to identify individuals at higher risk for AF. Fixed throughout a life course and assayable early in life, genetic biomarkers may meet this need. Here, we investigate whether multiple single nucleotide polymorphisms together as an AF genetic risk score (AF-GRS) can improve prediction of one's risk for AF.

AB - Atrial fibrillation (AF) is prevalent and there is a clinical need for biomarkers to identify individuals at higher risk for AF. Fixed throughout a life course and assayable early in life, genetic biomarkers may meet this need. Here, we investigate whether multiple single nucleotide polymorphisms together as an AF genetic risk score (AF-GRS) can improve prediction of one's risk for AF.

U2 - 10.1161/STROKEAHA.114.006072

DO - 10.1161/STROKEAHA.114.006072

M3 - Article

C2 - 25123217

SN - 1524-4628

VL - 45

SP - 2856

JO - Stroke: a journal of cerebral circulation

JF - Stroke: a journal of cerebral circulation

IS - 10

ER -

Twelve-Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke.

Abstract

Subject classification (UKÄ)

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