Type 1 diabetes-related autoantibodies are rare in Alaska native populations.

J Mohatt; LK Gilliam; L Bekris; S Ebbesson; Åke Lernmark

doi:10.3402/ijch.v61i0.17402

Type 1 diabetes-related autoantibodies are rare in Alaska native populations.

J Mohatt, LK Gilliam, L Bekris, S Ebbesson, Åke Lernmark

University of Washington, Seattle

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like islet antigen-2 (IA-2Ab). RESULTS: Among subjects from one Inupiat village (#1) and one SiberianYup'ik village (#2), there were 21 subjects with diabetes mellitus (DM), 17 with impaired glucose tolerance (IGT), and 226 healthy controls with normal gluco

Original language	English
Pages (from-to)	21-31
Journal	International Journal of Circumpolar Health
Volume	61
Issue number	1
DOIs	https://doi.org/10.3402/ijch.v61i0.17402
Publication status	Published - 2002
Externally published	Yes

Subject classification (UKÄ)

Endocrinology and Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3402/ijch.v61i0.17402Licence: Unspecified

https://www.tandfonline.com/doi/abs/10.3402/ijch.v61i0.17402Licence: Other

Cite this

@article{9ce06c8b94a54e248fcde9c2c4135f95,

title = "Type 1 diabetes-related autoantibodies are rare in Alaska native populations.",

abstract = "OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like islet antigen-2 (IA-2Ab). RESULTS: Among subjects from one Inupiat village (#1) and one SiberianYup'ik village (#2), there were 21 subjects with diabetes mellitus (DM), 17 with impaired glucose tolerance (IGT), and 226 healthy controls with normal gluco",

author = "J Mohatt and LK Gilliam and L Bekris and S Ebbesson and {\AA}ke Lernmark",

year = "2002",

doi = "10.3402/ijch.v61i0.17402",

language = "English",

volume = "61",

pages = "21--31",

journal = "International Journal of Circumpolar Health",

issn = "2242-3982",

publisher = "International Journal of Circumpolar Health",

number = "1",

}

TY - JOUR

T1 - Type 1 diabetes-related autoantibodies are rare in Alaska native populations.

AU - Mohatt, J

AU - Gilliam, LK

AU - Bekris, L

AU - Ebbesson, S

AU - Lernmark, Åke

PY - 2002

Y1 - 2002

N2 - OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like islet antigen-2 (IA-2Ab). RESULTS: Among subjects from one Inupiat village (#1) and one SiberianYup'ik village (#2), there were 21 subjects with diabetes mellitus (DM), 17 with impaired glucose tolerance (IGT), and 226 healthy controls with normal gluco

AB - OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like islet antigen-2 (IA-2Ab). RESULTS: Among subjects from one Inupiat village (#1) and one SiberianYup'ik village (#2), there were 21 subjects with diabetes mellitus (DM), 17 with impaired glucose tolerance (IGT), and 226 healthy controls with normal gluco

U2 - 10.3402/ijch.v61i0.17402

DO - 10.3402/ijch.v61i0.17402

M3 - Article

SN - 2242-3982

VL - 61

SP - 21

EP - 31

JO - International Journal of Circumpolar Health

JF - International Journal of Circumpolar Health

IS - 1

ER -

Type 1 diabetes-related autoantibodies are rare in Alaska native populations.

Abstract

Subject classification (UKÄ)

UN SDGs

Access to Document

Fingerprint

Cite this