Ultrasonographic findings in spontaneous miscarriage: relation to euploidy and aneuploidy

Elisabeth Ljunger, Anneli Stavreus-Evers, Sven Cnattingius, Anders Ekbom, Catarina Lundin, Goran Anneren, Inger Sundstrom-Poromaa

Research output: Contribution to journalArticlepeer-review

13 Citations (SciVal)

Abstract

Objective: To evaluate a possible correlation between transvaginal ultrasound findings in miscarriages and cytogenetic analyses from chorionic villi obtained by dilatation and curettage. Design: Prospective, population-based study. Setting: University-based hospital. Patient(s): Five hundred seventy-six women with spontaneous miscarriage diagnosed between 6 and 12 completed pregnancy weeks. Intervention(s): Transvaginal ultrasonography and dilatation and curettage. Main Outcome Measure(s): Cytogenetic analyses and ultrasound measurement of embryonic pole. Result(s): The mean gestational age was 9.5 weeks. Chromosomal analyses were successful in 259 cases, 159 with cytogenetic abnormalities and 100 euploidy. Empty gestational sacs were equally often found in euploidy and aneuploidy, whereas small embryonic or fetal poles were significantly more often associated with aneuploidy. Conclusion(s): A smaller than expected fetal size when a miscarriage is diagnosed during the first trimester is significantly associated with a chromosomal aberration. (Fertil Steril(R) 2011;95:221-4. (C) 2011 by American Society for Reproductive Medicine.)
Original languageEnglish
Pages (from-to)221-224
JournalFertility and Sterility
Volume95
Issue number1
DOIs
Publication statusPublished - 2011

Subject classification (UKÄ)

  • Obstetrics, Gynecology and Reproductive Medicine

Keywords

  • Miscarriage
  • karyotype
  • ultrasonography

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