Use of ciprofloxacin in patients undergoing transurethral prostatic surgery

Sverker Hellsten, Arne Forsgren, Thomas Björk, Magnus Grabe

Research output: Contribution to journalArticlepeer-review

Abstract

The efficacy of a short (Group I) and a prolonged (Group II) course with ciprofloxacin was assessed in patients undergoing transurethral prostatic resection and compared with that of controls without antibiotic (Group III). Both regimens significantly reduced the frequency of post-operative bacteriuria (p less than 0.01) and of severe infectious complications (p = 0.004) compared to the controls. Both regimens were equally effective in preventing peri-operative and post-operative acquisition of bacteriuria in patients without bacteriuria at surgery. In patients with bacteriuria before surgery, bacteriuria was found post-operatively in 35% in Group I and in 9% in Group II (p = 0.012), but in 82% of the patients in Group III. Ciprofloxacin inhibited all but 7 of 176 bacterial strains at an MIC of less than or equal to 1 microgram/ml. Given orally, ciprofloxacin is a valuable alternative antimicrobial for use in conjunction with transurethral prostatic resection. A short course is sufficient for prophylaxis, and adequate therapy is achieved with a prolonged regimen.
Original languageEnglish
Pages (from-to)104-107
JournalScandinavian Journal of Infectious Diseases. Supplementum
Volume60
Publication statusPublished - 1989

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Division of Urological Cancers (013243420), Clinical Microbiology, Malmö (013011000), Urology (013243400)

Subject classification (UKÄ)

  • Clinical Medicine
  • Microbiology in the medical area
  • Cancer and Oncology
  • Urology and Nephrology

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