Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates

Natalija Karabasevic; Jason A. Roberts; Luke Stronach; Saiyuri Naicker; Steven C. Wallis; Fredrik Sjövall; Fekade Sime

doi:10.1128/aac.02140-21

Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates

Natalija Karabasevic, Jason A. Roberts, Luke Stronach, Saiyuri Naicker, Steven C. Wallis, Fredrik Sjövall, Fekade Sime

Research output: Contribution to journal › Article › peer-review

Abstract

Meropenem-ciprofloxacin combination therapy was compared to the respective monotherapy in a Hollow-Fiber Infection Model against two Pseudomonas aeruginosa isolates. Following initial kill of ; 5-logs by each monotherapy, rapid regrowth occurred within 24 h, reaching 108 - 1010 CFU/mL at 120 h. In contrast, combination therapy achieved . 5-log kill within 6 h and suppressed bacterial regrowth throughout. The results suggest that meropenem-ciprofloxacin combination may provide significantly enhanced bacterial killing and resistance suppression against P. aeruginosa.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	66
Issue number	5
DOIs	https://doi.org/10.1128/aac.02140-21
Publication status	Published - 2022 May

Subject classification (UKÄ)

Biological Sciences

Free keywords

combination therapy
Hollow-Fiber Infection Model
Pseudomonas aeruginosa

Access to Document

10.1128/aac.02140-21

Fingerprint

Dive into the research topics of 'Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates'. Together they form a unique fingerprint.

Cite this

Karabasevic, N., Roberts, J. A., Stronach, L., Naicker, S., Wallis, S. C., Sjövall, F., & Sime, F. (2022). Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates. Antimicrobial Agents and Chemotherapy, 66(5). https://doi.org/10.1128/aac.02140-21

@article{78066f5c794a422e86b63bfa19a0df8e,

title = "Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates",

abstract = "Meropenem-ciprofloxacin combination therapy was compared to the respective monotherapy in a Hollow-Fiber Infection Model against two Pseudomonas aeruginosa isolates. Following initial kill of ; 5-logs by each monotherapy, rapid regrowth occurred within 24 h, reaching 108 - 1010 CFU/mL at 120 h. In contrast, combination therapy achieved . 5-log kill within 6 h and suppressed bacterial regrowth throughout. The results suggest that meropenem-ciprofloxacin combination may provide significantly enhanced bacterial killing and resistance suppression against P. aeruginosa. ",

keywords = "combination therapy, Hollow-Fiber Infection Model, Pseudomonas aeruginosa",

author = "Natalija Karabasevic and Roberts, \{Jason A.\} and Luke Stronach and Saiyuri Naicker and Wallis, \{Steven C.\} and Fredrik Sj{\"o}vall and Fekade Sime",

note = "Publisher Copyright: {\textcopyright} 2022 American Society for Microbiology.",

year = "2022",

month = may,

doi = "10.1128/aac.02140-21",

language = "English",

volume = "66",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "5",

}

Karabasevic, N, Roberts, JA, Stronach, L, Naicker, S, Wallis, SC, Sjövall, F & Sime, F 2022, 'Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates', Antimicrobial Agents and Chemotherapy, vol. 66, no. 5. https://doi.org/10.1128/aac.02140-21

Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates. / Karabasevic, Natalija; Roberts, Jason A.; Stronach, Luke et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 66, No. 5, 05.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates

AU - Karabasevic, Natalija

AU - Roberts, Jason A.

AU - Stronach, Luke

AU - Naicker, Saiyuri

AU - Wallis, Steven C.

AU - Sjövall, Fredrik

AU - Sime, Fekade

PY - 2022/5

Y1 - 2022/5

N2 - Meropenem-ciprofloxacin combination therapy was compared to the respective monotherapy in a Hollow-Fiber Infection Model against two Pseudomonas aeruginosa isolates. Following initial kill of ; 5-logs by each monotherapy, rapid regrowth occurred within 24 h, reaching 108 - 1010 CFU/mL at 120 h. In contrast, combination therapy achieved . 5-log kill within 6 h and suppressed bacterial regrowth throughout. The results suggest that meropenem-ciprofloxacin combination may provide significantly enhanced bacterial killing and resistance suppression against P. aeruginosa.

AB - Meropenem-ciprofloxacin combination therapy was compared to the respective monotherapy in a Hollow-Fiber Infection Model against two Pseudomonas aeruginosa isolates. Following initial kill of ; 5-logs by each monotherapy, rapid regrowth occurred within 24 h, reaching 108 - 1010 CFU/mL at 120 h. In contrast, combination therapy achieved . 5-log kill within 6 h and suppressed bacterial regrowth throughout. The results suggest that meropenem-ciprofloxacin combination may provide significantly enhanced bacterial killing and resistance suppression against P. aeruginosa.

KW - combination therapy

KW - Hollow-Fiber Infection Model

KW - Pseudomonas aeruginosa

UR - https://www.scopus.com/pages/publications/85130506452

U2 - 10.1128/aac.02140-21

DO - 10.1128/aac.02140-21

M3 - Article

C2 - 35389238

AN - SCOPUS:85130506452

SN - 0066-4804

VL - 66

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Karabasevic N, Roberts JA, Stronach L, Naicker S, Wallis SC, Sjövall F et al. Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates. Antimicrobial Agents and Chemotherapy. 2022 May;66(5). doi: 10.1128/aac.02140-21

Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates

Abstract

Subject classification (UKÄ)

Free keywords

Access to Document

Other files and links

Fingerprint

Cite this