Variation and covariation in patch test reactivity to palladium and nickel salts

Lisbeth Rosholm Comstedt, Malin Engfeldt, Cecilia Svedman, Anna Åkesson, Monica Hindsén, Magnus Bruze

Research output: Contribution to journalArticlepeer-review

4 Citations (SciVal)

Abstract

Concomitant reactions to palladium chloride (PdCl2), sodium tetrachloropalladate (Na2PdCl4), and nickel hexahydrate sulphate (NiSO4·6H2O) are very common during patch testing and have mainly been explained by cross-sensitisation. Whether there is variation in reactivity to palladium or covariation to nickel and palladium is not known. The aim of this study was to investigate the variation in patch test reactivity to PdCl2 and Na2PdCl4 over time and compare this to variation in patch test reactivity to NiSO4·6H2O. Fifteen females known to be sensitised to nickel and palladium were patch tested four times with 12-week intervals using a dilution series of NiSO4·6H2O, PdCl2 or Na2PdCl4. Patch test reactivity to Na2PdCl4 was less variable compared to that for NiSO4·6H2O or PdCl2. All test salts showed higher patch test reactivity during wintertime. No significant correlation was observed between the variation in patch test reactivity to Na2PdCl4 and PdCl2 and the variation in patch test reactivity to NiSO4·6H2O during the entire test period. Patch test reactivity to Na2PdCl4 is less variable over time compared to that for PdCl2 or NiSO4·6H2O. No clear covariation was identified between tests for palladium salts and NiSO4·6H2O. The variation in patch test reactivity found in this study could be due to seasonal changes.

Original languageEnglish
Pages (from-to)668-676
Number of pages9
JournalEuropean journal of dermatology : EJD
Volume28
Issue number5
DOIs
Publication statusPublished - 2018

Subject classification (UKÄ)

  • Dermatology and Venereal Diseases

Keywords

  • contact allergy
  • delayed hypersensitivity
  • equimolar
  • false-negative
  • metal salts
  • seasonal influence

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