Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma

Matthew Frampton; Miguel Inacio da Silva Filho; Peter Broderick; Hauke Thomsen; Asta Försti; Jayaram Vijayakrishnan; Rosie Cooke; Victor Enciso-Mora; Per Hoffmann; Markus M. Noethen; Amy Lloyd; Amy Holroyd; Lewin Eisele; Karl-Heinz Joeckel; Sabine Ponader; Elke Pogge von Strandmann; Tracy Lightfoot; Eve Roman; Annette Lake; Dorothy Montgomery; Ruth F. Jarrett; Anthony J. Swerdlow; Andreas Engert; Kari Hemminki; Richard S. Houlston

doi:10.1038/ncomms3549

Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma

Matthew Frampton, Miguel Inacio da Silva Filho, Peter Broderick, Hauke Thomsen, Asta Försti, Jayaram Vijayakrishnan, Rosie Cooke, Victor Enciso-Mora, Per Hoffmann, Markus M. Noethen, Amy Lloyd, Amy Holroyd, Lewin Eisele, Karl-Heinz Joeckel, Sabine Ponader, Elke Pogge von Strandmann, Tracy Lightfoot, Eve Roman, Annette Lake, Dorothy MontgomeryRuth F. Jarrett, Anthony J. Swerdlow, Andreas Engert, Kari Hemminki, Richard S. Houlston

Research output: Contribution to journal › Article › peer-review

Abstract

In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P = 1.14 x 10(-12), odds ratio (OR) = 1.26) and 6q23.3 (rs7745098; P = 3.42 x 10(-9), OR = 1.21). rs3806624 localizes 5' to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.

Original language	English
Article number	2549
Journal	Nature Communications
Volume	4
DOIs	https://doi.org/10.1038/ncomms3549
Publication status	Published - 2013

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Health Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Frampton, M., da Silva Filho, M. I., Broderick, P., Thomsen, H., Försti, A., Vijayakrishnan, J., Cooke, R., Enciso-Mora, V., Hoffmann, P., Noethen, M. M., Lloyd, A., Holroyd, A., Eisele, L., Joeckel, K.-H., Ponader, S., von Strandmann, E. P., Lightfoot, T., Roman, E., Lake, A., ... Houlston, R. S. (2013). Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma. Nature Communications, 4, Article 2549. https://doi.org/10.1038/ncomms3549

@article{0ae1eff729b840f8b79d3ca715689c99,

title = "Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma",

abstract = "In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P = 1.14 x 10(-12), odds ratio (OR) = 1.26) and 6q23.3 (rs7745098; P = 3.42 x 10(-9), OR = 1.21). rs3806624 localizes 5' to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.",

author = "Matthew Frampton and {da Silva Filho}, {Miguel Inacio} and Peter Broderick and Hauke Thomsen and Asta F{\"o}rsti and Jayaram Vijayakrishnan and Rosie Cooke and Victor Enciso-Mora and Per Hoffmann and Noethen, {Markus M.} and Amy Lloyd and Amy Holroyd and Lewin Eisele and Karl-Heinz Joeckel and Sabine Ponader and {von Strandmann}, {Elke Pogge} and Tracy Lightfoot and Eve Roman and Annette Lake and Dorothy Montgomery and Jarrett, {Ruth F.} and Swerdlow, {Anthony J.} and Andreas Engert and Kari Hemminki and Houlston, {Richard S.}",

year = "2013",

doi = "10.1038/ncomms3549",

language = "English",

volume = "4",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

Frampton, M, da Silva Filho, MI, Broderick, P, Thomsen, H, Försti, A, Vijayakrishnan, J, Cooke, R, Enciso-Mora, V, Hoffmann, P, Noethen, MM, Lloyd, A, Holroyd, A, Eisele, L, Joeckel, K-H, Ponader, S, von Strandmann, EP, Lightfoot, T, Roman, E, Lake, A, Montgomery, D, Jarrett, RF, Swerdlow, AJ, Engert, A, Hemminki, K & Houlston, RS 2013, 'Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma', Nature Communications, vol. 4, 2549. https://doi.org/10.1038/ncomms3549

TY - JOUR

T1 - Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma

AU - Frampton, Matthew

AU - da Silva Filho, Miguel Inacio

AU - Broderick, Peter

AU - Thomsen, Hauke

AU - Försti, Asta

AU - Vijayakrishnan, Jayaram

AU - Cooke, Rosie

AU - Enciso-Mora, Victor

AU - Hoffmann, Per

AU - Noethen, Markus M.

AU - Lloyd, Amy

AU - Holroyd, Amy

AU - Eisele, Lewin

AU - Joeckel, Karl-Heinz

AU - Ponader, Sabine

AU - von Strandmann, Elke Pogge

AU - Lightfoot, Tracy

AU - Roman, Eve

AU - Lake, Annette

AU - Montgomery, Dorothy

AU - Jarrett, Ruth F.

AU - Swerdlow, Anthony J.

AU - Engert, Andreas

AU - Hemminki, Kari

AU - Houlston, Richard S.

PY - 2013

Y1 - 2013

N2 - In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P = 1.14 x 10(-12), odds ratio (OR) = 1.26) and 6q23.3 (rs7745098; P = 3.42 x 10(-9), OR = 1.21). rs3806624 localizes 5' to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.

AB - In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P = 1.14 x 10(-12), odds ratio (OR) = 1.26) and 6q23.3 (rs7745098; P = 3.42 x 10(-9), OR = 1.21). rs3806624 localizes 5' to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.

U2 - 10.1038/ncomms3549

DO - 10.1038/ncomms3549

M3 - Article

C2 - 24149102

SN - 2041-1723

VL - 4

JO - Nature Communications

JF - Nature Communications

M1 - 2549

ER -

Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma

Abstract

Subject classification (UKÄ)

UN SDGs

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