Vascular endothelial growth factor gene polymorphisms and pre-eclampsia

D Papazoglou, G Galazios, MI Koukourakis, Ioannis Panagopoulos, EN Kontomanolis, K Papatheodorou, E Maltezos

Research output: Contribution to journalArticlepeer-review

Abstract

Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 healthy control women who were genotyped for the -2578C/A, -634G/C and 936C/T polymorphisms of the VEGF gene. No significant association between genotypic or allelic frequencies in women with pre-eclampsia relative to controls was found. A statistically significant difference was found for allelic frequencies of the 936C/T polymorphism between women with severe pre-eclampsia and controls (odds ratio: 2.70; 95% confidence interval: 1.09-6.63; P = 0.019). VEGF gene polymorphisms studied are unlikely to be major predisposing factors for pre-eclampsia. The presence of the 936T allele probably has a considerable effect on disease modification.
Original languageEnglish
Pages (from-to)321-324
JournalMolecular Human Reproduction
Volume10
Issue number5
DOIs
Publication statusPublished - 2004

Subject classification (UKÄ)

  • Obstetrics, Gynecology and Reproductive Medicine

Free keywords

  • vascular endothelial growth factor
  • pre-eclampsia
  • polymorphisms

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