Visual outcome is similar in optic neuritis patients treated with oral and i.v. high-dose methylprednisolone: a retrospective study on 56 patients

Magdalena Naumovska, Rafi Sheikh, Boel Bengtsson, Malin Malmsjö, Björn Hammar

Research output: Contribution to journalArticlepeer-review

5 Citations (SciVal)

Abstract

BACKGROUND: To investigate visual recovery after treatment of acute optic neuritis (ON) with either oral or intravenous high-dose methylprednisolone, in order to establish the best route of administration.
METHODS: Retrospective analysis of patients treated with oral or intravenous high-dose (≥500 mg per day) methylprednisolone for acute ON of unknown or demyelinating etiology. Twenty-eight patients were included in each treatment group. Visual acuity was measured with the Snellen letter chart, color vision with Boström-Kugelberg pseudo-isochromatic plates, and visual field with a Humphrey Field Analyzer.
RESULTS: The treatment results were similar in the two groups at follow-up, with no significant difference in visual acuity (p = 0.54), color vision (p = 0.18), visual field mean deviation (p = 0.39) or the number of highly significantly depressed test points (p = 0.46).
CONCLUSIONS: The results show no clinical disadvantage of using oral high-dose corticosteroids compared to intravenous administration in the treatment of acute ON, which would facilitate the clinical management of these patients.
Original languageEnglish
Article number160
JournalBMC Neurology
Volume18
DOIs
Publication statusPublished - 2018 Sep 30

Subject classification (UKÄ)

  • Ophthalmology

Fingerprint

Dive into the research topics of 'Visual outcome is similar in optic neuritis patients treated with oral and i.v. high-dose methylprednisolone: a retrospective study on 56 patients'. Together they form a unique fingerprint.

Cite this