Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions. This review discusses the effects of different vitamin K subspecies on tumour growth and the possible anti-tumour effects of increased vitamin K intake. Blocking carboxylation of vitamin K-dependent proteins with warfarin anticoagulation – what are the risks/benefits for carcinogenesis? Previous studies on both heparin and low molecular weight heparin blocking of the vitamin K-dependent factors X and II have shown tumour suppressive effects. Vitamin K has anti-inflammatory effects that could also impact carcinogenesis, but little data exists on this subject.

Original languageEnglish
Pages (from-to)555-567
JournalScandinavian Journal of Clinical and Laboratory Investigation
Issue number8
Early online date2017 Sept 21
Publication statusPublished - 2017

Subject classification (UKÄ)

  • Cancer and Oncology

Free keywords

  • anticoagulants
  • apoptosis
  • cell cycle checkpoints
  • growth arrest-specific protein 6
  • matrix Gla protein
  • neoplasm
  • osteocalcin
  • steroid and xenobiotic receptor
  • Vitamin K


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