Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

Agneta Scheja; Anita Åkesson; Pierre Geborek; Marie Wildt; Claes B Wollheim; Frank Wollheim; Ulrich M Vischer

doi:10.1186/ar295

Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

Agneta Scheja, Anita Åkesson, Pierre Geborek, Marie Wildt, Claes B Wollheim, Frank Wollheim, Ulrich M Vischer

Rheumatology

Research output: Contribution to journal › Article › peer-review

Abstract

In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.

Original language	English
Pages (from-to)	178-182
Journal	Arthritis Research & Therapy
Volume	3
Issue number	3
DOIs	https://doi.org/10.1186/ar295
Publication status	Published - 2001

Subject classification (UKÄ)

Rheumatology and Autoimmunity

Keywords

systemic sclerosis
von Willebrand factor
von Willebrand factor propeptide

Access to Document

10.1186/ar295

Cite this

@article{fec12d67d0de47c88091bd431c9b476b,

title = "Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)",

abstract = "In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.",

keywords = "systemic sclerosis, von Willebrand factor, von Willebrand factor propeptide",

author = "Agneta Scheja and Anita {\AA}kesson and Pierre Geborek and Marie Wildt and Wollheim, {Claes B} and Frank Wollheim and Vischer, {Ulrich M}",

year = "2001",

doi = "10.1186/ar295",

language = "English",

volume = "3",

pages = "178--182",

journal = "Arthritis Research & Therapy",

issn = "1478-6354",

publisher = "BioMed Central (BMC)",

number = "3",

}

TY - JOUR

T1 - Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

AU - Scheja, Agneta

AU - Åkesson, Anita

AU - Geborek, Pierre

AU - Wildt, Marie

AU - Wollheim, Claes B

AU - Wollheim, Frank

AU - Vischer, Ulrich M

PY - 2001

Y1 - 2001

N2 - In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.

AB - In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.

KW - systemic sclerosis

KW - von Willebrand factor

KW - von Willebrand factor propeptide

U2 - 10.1186/ar295

DO - 10.1186/ar295

M3 - Article

SN - 1478-6354

VL - 3

SP - 178

EP - 182

JO - Arthritis Research & Therapy

JF - Arthritis Research & Therapy

IS - 3

ER -

Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

Abstract

Subject classification (UKÄ)

Keywords

Access to Document

Fingerprint

Cite this