Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

Agneta Scheja, Anita Åkesson, Pierre Geborek, Marie Wildt, Claes B Wollheim, Frank Wollheim, Ulrich M Vischer

Research output: Contribution to journalArticlepeer-review

Abstract

In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.
Original languageEnglish
Pages (from-to)178-182
JournalArthritis Research & Therapy
Volume3
Issue number3
DOIs
Publication statusPublished - 2001

Subject classification (UKÄ)

  • Rheumatology and Autoimmunity

Free keywords

  • systemic sclerosis
  • von Willebrand factor
  • von Willebrand factor propeptide

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