Walking by design: how to build artificial molecular motors made of proteins

Patrik F. Nilsson; Anna Zink; Olivier M.C. Laprévote; Chapin S. Korosec; Nils Gustafsson; Neil O. Robertson; Nancy R. Forde; Ralf Eichhorn; Birte Höcker; Paul M.G. Curmi; Heiner Linke

doi:10.1088/2399-1984/ad7d7e

Walking by design: how to build artificial molecular motors made of proteins

Patrik F. Nilsson, Anna Zink, Olivier M.C. Laprévote, Chapin S. Korosec, Nils Gustafsson, Neil O. Robertson, Nancy R. Forde, Ralf Eichhorn, Birte Höcker, Paul M.G. Curmi, Heiner Linke

Research output: Contribution to journal › Article › peer-review

Abstract

To design an artificial protein-based molecular motor that can autonomously step along a track is a key challenge of protein design and synthetic biology. We lay out a roadmap for how to achieve this aim, based on a modular approach that combines the use of natural, non-motor proteins with de novo design. We define what can be considered to constitute a successful artificial protein motor, identify key steps along the path to achieve these designs, and provide a vision for the future beyond this aim.

Original language	English
Article number	042501
Journal	Nano Futures
Volume	8
Issue number	4
DOIs	https://doi.org/10.1088/2399-1984/ad7d7e
Publication status	Published - 2024 Dec 1

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Published by IOP Publishing Ltd.

Subject classification (UKÄ)

Condensed Matter Physics (including Material Physics, Nano Physics)

Free keywords

molecular motors
nanotechnology
protein design
proteins
synthetic biology

Access to Document

10.1088/2399-1984/ad7d7e

Cite this

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title = "Walking by design: how to build artificial molecular motors made of proteins",

abstract = "To design an artificial protein-based molecular motor that can autonomously step along a track is a key challenge of protein design and synthetic biology. We lay out a roadmap for how to achieve this aim, based on a modular approach that combines the use of natural, non-motor proteins with de novo design. We define what can be considered to constitute a successful artificial protein motor, identify key steps along the path to achieve these designs, and provide a vision for the future beyond this aim.",

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AU - Nilsson, Patrik F.

AU - Zink, Anna

AU - Laprévote, Olivier M.C.

AU - Korosec, Chapin S.

AU - Gustafsson, Nils

AU - Robertson, Neil O.

AU - Forde, Nancy R.

AU - Eichhorn, Ralf

AU - Höcker, Birte

AU - Curmi, Paul M.G.

AU - Linke, Heiner

PY - 2024/12/1

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N2 - To design an artificial protein-based molecular motor that can autonomously step along a track is a key challenge of protein design and synthetic biology. We lay out a roadmap for how to achieve this aim, based on a modular approach that combines the use of natural, non-motor proteins with de novo design. We define what can be considered to constitute a successful artificial protein motor, identify key steps along the path to achieve these designs, and provide a vision for the future beyond this aim.

AB - To design an artificial protein-based molecular motor that can autonomously step along a track is a key challenge of protein design and synthetic biology. We lay out a roadmap for how to achieve this aim, based on a modular approach that combines the use of natural, non-motor proteins with de novo design. We define what can be considered to constitute a successful artificial protein motor, identify key steps along the path to achieve these designs, and provide a vision for the future beyond this aim.

KW - molecular motors

KW - nanotechnology

KW - protein design

KW - proteins

KW - synthetic biology

U2 - 10.1088/2399-1984/ad7d7e

DO - 10.1088/2399-1984/ad7d7e

M3 - Article

AN - SCOPUS:85206882043

SN - 2399-1984

VL - 8

JO - Nano Futures

JF - Nano Futures

IS - 4

M1 - 042501

ER -

Walking by design: how to build artificial molecular motors made of proteins

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

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