WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.

Anne-Mari Moilanen; Jaana Rysä; Leena Kaikkonen; Teemu Karvonen; Erja Mustonen; Raisa Serpi; Zoltán Szabó; Olli Tenhunen; Zsolt Bagyura; Juha Näpänkangas; Pauli Ohukainen; Pasi Tavi; Risto Kerkelä; Margrét Leosdottir; Björn Wahlstrand; Thomas Hedner; Olle Melander; Heikki Ruskoaho

doi:10.1371/journal.pone.0124907

WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.

Anne-Mari Moilanen, Jaana Rysä, Leena Kaikkonen, Teemu Karvonen, Erja Mustonen, Raisa Serpi, Zoltán Szabó, Olli Tenhunen, Zsolt Bagyura, Juha Näpänkangas, Pauli Ohukainen, Pasi Tavi, Risto Kerkelä, Margrét Leosdottir, Björn Wahlstrand, Thomas Hedner, Olle Melander, Heikki Ruskoaho

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Abstract

In a recent genome-wide association study, WD-repeat domain 12 (WDR12) was associated with early-onset myocardial infarction (MI). However, the function of WDR12 in the heart is unknown.

Original language	English
Article number	e0124907
Journal	PLoS ONE
Volume	10
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0124907
Publication status	Published - 2015

Subject classification (UKÄ)

Other Clinical Medicine
Cardiology and Cardiovascular Disease

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http://www.ncbi.nlm.nih.gov/pubmed/25915632?dopt=Abstract

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Moilanen, A.-M., Rysä, J., Kaikkonen, L., Karvonen, T., Mustonen, E., Serpi, R., Szabó, Z., Tenhunen, O., Bagyura, Z., Näpänkangas, J., Ohukainen, P., Tavi, P., Kerkelä, R., Leosdottir, M., Wahlstrand, B., Hedner, T., Melander, O., & Ruskoaho, H. (2015). WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function. PLoS ONE, 10(4), Article e0124907. https://doi.org/10.1371/journal.pone.0124907

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title = "WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.",

abstract = "In a recent genome-wide association study, WD-repeat domain 12 (WDR12) was associated with early-onset myocardial infarction (MI). However, the function of WDR12 in the heart is unknown.",

author = "Anne-Mari Moilanen and Jaana Rys{\"a} and Leena Kaikkonen and Teemu Karvonen and Erja Mustonen and Raisa Serpi and Zolt{\'a}n Szab{\'o} and Olli Tenhunen and Zsolt Bagyura and Juha N{\"a}p{\"a}nkangas and Pauli Ohukainen and Pasi Tavi and Risto Kerkel{\"a} and Margr{\'e}t Leosdottir and Bj{\"o}rn Wahlstrand and Thomas Hedner and Olle Melander and Heikki Ruskoaho",

year = "2015",

doi = "10.1371/journal.pone.0124907",

language = "English",

volume = "10",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science (PLoS)",

number = "4",

}

Moilanen, A-M, Rysä, J, Kaikkonen, L, Karvonen, T, Mustonen, E, Serpi, R, Szabó, Z, Tenhunen, O, Bagyura, Z, Näpänkangas, J, Ohukainen, P, Tavi, P, Kerkelä, R, Leosdottir, M, Wahlstrand, B, Hedner, T, Melander, O & Ruskoaho, H 2015, 'WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.', PLoS ONE, vol. 10, no. 4, e0124907. https://doi.org/10.1371/journal.pone.0124907

TY - JOUR

T1 - WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.

AU - Moilanen, Anne-Mari

AU - Rysä, Jaana

AU - Kaikkonen, Leena

AU - Karvonen, Teemu

AU - Mustonen, Erja

AU - Serpi, Raisa

AU - Szabó, Zoltán

AU - Tenhunen, Olli

AU - Bagyura, Zsolt

AU - Näpänkangas, Juha

AU - Ohukainen, Pauli

AU - Tavi, Pasi

AU - Kerkelä, Risto

AU - Leosdottir, Margrét

AU - Wahlstrand, Björn

AU - Hedner, Thomas

AU - Melander, Olle

AU - Ruskoaho, Heikki

PY - 2015

Y1 - 2015

N2 - In a recent genome-wide association study, WD-repeat domain 12 (WDR12) was associated with early-onset myocardial infarction (MI). However, the function of WDR12 in the heart is unknown.

AB - In a recent genome-wide association study, WD-repeat domain 12 (WDR12) was associated with early-onset myocardial infarction (MI). However, the function of WDR12 in the heart is unknown.

UR - https://www.scopus.com/pages/publications/84928550749

U2 - 10.1371/journal.pone.0124907

DO - 10.1371/journal.pone.0124907

M3 - Article

C2 - 25915632

SN - 1932-6203

VL - 10

JO - PLoS ONE

JF - PLoS ONE

IS - 4

M1 - e0124907

ER -

WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.

Abstract

Subject classification (UKÄ)

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