Abstract
Hereditary cancer that has monogenic inheritance affects every tenth patient, on average, who is diagnosed with cancer, and it has been suggested based on twin studies, that approximately 30% of all cancer patients have a genetic predisposition to developing cancer. The author posited that familial syndromes become more organ specific with increasing age at tumour presentation to the point that very late in life, only a few organs are affected by tumours disease. The reason for this could be that the tumour originates from a more differentiated, organ-specific progenitor/stem cell later in life, while the progenitor/stem cell might be involved in organogenesis in different organs earlier in life. Examples are given for skin cancer and breast cancer. Summary: Patients with familial cancer who present with cancer at an older age at tumour presentation have a more organ restricted disease. This could be because the tumor has a more differentiated progenitor/stem cell origin. Examples are given for families with breast cancer, melanoma, and non-melanoma skin cancer.
Original language | English |
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Article number | Abstract 2546 |
Journal | Cancer Research |
Volume | 76 |
Issue number | 14 Suppl |
DOIs | |
Publication status | Published - 2016 |
Event | American Association for Cancer Research (AACR) 107th Annual Meeting 2016 - New Orleans, United States Duration: 2016 Apr 16 → 2016 Apr 20 |
Subject classification (UKÄ)
- Cancer and Oncology
Free keywords
- breast cancer
- cancer epidemiology
- cancer patient
- clinical study
- diagnosis
- hereditary tumor syndrome
- female
- genetic predisposition
- human
- melanoma
- organogenesis
- skin cancer
- stem cell
- tumor diagnosis
- twin study