TY - JOUR
T1 - X-rays can trigger the FLASH effect
T2 - Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice
AU - Montay-Gruel, Pierre
AU - Bouchet, Audrey
AU - Jaccard, Maud
AU - Patin, David
AU - Serduc, Raphael
AU - Aim, Warren
AU - Petersson, Kristoffer
AU - Petit, Benoit
AU - Bailat, Claude
AU - Bourhis, Jean
AU - Bräuer-Krisch, Elke
AU - Vozenin, Marie Catherine
N1 - Publisher Copyright:
© 2018
PY - 2018
Y1 - 2018
N2 - This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.
AB - This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.
KW - Cognitive impairment
KW - Radiation-induced brain injury
KW - Synchrotron radiation
KW - Ultra-high dose-rate X-ray radiation
UR - http://www.scopus.com/inward/record.url?scp=85052736289&partnerID=8YFLogxK
U2 - 10.1016/j.radonc.2018.08.016
DO - 10.1016/j.radonc.2018.08.016
M3 - Article
C2 - 30177374
AN - SCOPUS:85052736289
SN - 0167-8140
VL - 129
SP - 582
EP - 588
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 3
ER -