Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition

Laurence Covassin; Michel Desjardins; Denis Soulet; Rene Charest-Gaudreault; Marie Audette; Richard Poulin

doi:10.1016/S0960-894X(03)00668-1

Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition

Laurence Covassin, Michel Desjardins, Denis Soulet, Rene Charest-Gaudreault, Marie Audette, Richard Poulin

Laval University

Research output: Contribution to journal › Article › peer-review

Abstract

Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.

Original language	English
Pages (from-to)	3267-3271
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	13
Issue number	19
DOIs	https://doi.org/10.1016/S0960-894X(03)00668-1
Publication status	Published - 2003
Externally published	Yes

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neuronal Survival (013212041)

Subject classification (UKÄ)

Neurosciences

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10.1016/S0960-894X(03)00668-1

Cite this

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title = "Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition",

abstract = "Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.",

author = "Laurence Covassin and Michel Desjardins and Denis Soulet and Rene Charest-Gaudreault and Marie Audette and Richard Poulin",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)",

year = "2003",

doi = "10.1016/S0960-894X(03)00668-1",

language = "English",

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T1 - Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition

AU - Covassin, Laurence

AU - Desjardins, Michel

AU - Soulet, Denis

AU - Charest-Gaudreault, Rene

AU - Audette, Marie

AU - Poulin, Richard

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)

PY - 2003

Y1 - 2003

N2 - Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.

AB - Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.

U2 - 10.1016/S0960-894X(03)00668-1

DO - 10.1016/S0960-894X(03)00668-1

M3 - Article

SN - 0960-894X

VL - 13

SP - 3267

EP - 3271

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 19

ER -

Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition

Abstract

Bibliographical note

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