Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats

Klinsmann Carolo Dos Santos; Bianca Guerra Bueno; Luana Ferreira Pereira; Fabiane Valentini Francisqueti; Mariana Gobbo Braz; Lahis Fernandes Bincoleto; Lilian Xavier Da Silva; Ana Lúcia A. Ferreira; Ana Cláudia De Melo Stevanato Nakamune; C. Y.Oliver Chen; Jeffrey B. Blumberg; Camila Renata Corrêa

doi:10.1155/2017/6418048

Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats

Klinsmann Carolo Dos Santos, Bianca Guerra Bueno, Luana Ferreira Pereira, Fabiane Valentini Francisqueti, Mariana Gobbo Braz, Lahis Fernandes Bincoleto, Lilian Xavier Da Silva, Ana Lúcia A. Ferreira, Ana Cláudia De Melo Stevanato Nakamune, C. Y.Oliver Chen, Jeffrey B. Blumberg, Camila Renata Corrêa

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of hydroethanolic extract of Yacon leaves (HEYL) on antioxidant, glycemic, and inflammatory biomarkers were tested in diabetic rats. Outcome parameters included glucose, insulin, interleukin-6 (IL-6), and hydrophilic antioxidant capacity (HAC) in serum and IL-6, HAC, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in soleus. The rats (10/group) were divided as follows: C, controls; C + Y, HEYL treated; DM, diabetic controls; and DM + Y, diabetic rats treated with HEYL. Diabetes mellitus was induced by administration of streptozotocin. C + Y and DM + Y groups received 100 mg/kg HEYL daily via gavage for 30 d. Hyperglycemia was improved in the DM + Y versus DM group. Insulin was reduced in DM versus C group. DM rats had higher IL-6 and MDA and lower HAC in the soleus muscle. HEYL treatment decreased IL-6 and MDA and increased HAC in DM rats. DM + Y rats had the highest CAT activity versus the other groups; GPx was higher in C + Y and DM + Y versus their respective controls. The apparent benefit of HEYL may be mediated via improving glucoregulation and ameliorating oxidative stress and inflammation, particularly in diabetic rats.

Original language	English
Article number	6418048
Journal	Evidence-based Complementary and Alternative Medicine
Volume	2017
DOIs	https://doi.org/10.1155/2017/6418048
Publication status	Published - 2017 Jan 1
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Endocrinology and Diabetes

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10.1155/2017/6418048Licence: CC BY

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Dos Santos, K. C., Bueno, B. G., Pereira, L. F., Francisqueti, F. V., Braz, M. G., Bincoleto, L. F., Da Silva, L. X., Ferreira, A. L. A., De Melo Stevanato Nakamune, A. C., Chen, C. Y. O., Blumberg, J. B., & Corrêa, C. R. (2017). Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats. Evidence-based Complementary and Alternative Medicine, 2017, Article 6418048. https://doi.org/10.1155/2017/6418048

@article{7a7defd3ee264b7caa87dc08fee144d9,

title = "Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats",

abstract = "The effects of hydroethanolic extract of Yacon leaves (HEYL) on antioxidant, glycemic, and inflammatory biomarkers were tested in diabetic rats. Outcome parameters included glucose, insulin, interleukin-6 (IL-6), and hydrophilic antioxidant capacity (HAC) in serum and IL-6, HAC, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in soleus. The rats (10/group) were divided as follows: C, controls; C + Y, HEYL treated; DM, diabetic controls; and DM + Y, diabetic rats treated with HEYL. Diabetes mellitus was induced by administration of streptozotocin. C + Y and DM + Y groups received 100 mg/kg HEYL daily via gavage for 30 d. Hyperglycemia was improved in the DM + Y versus DM group. Insulin was reduced in DM versus C group. DM rats had higher IL-6 and MDA and lower HAC in the soleus muscle. HEYL treatment decreased IL-6 and MDA and increased HAC in DM rats. DM + Y rats had the highest CAT activity versus the other groups; GPx was higher in C + Y and DM + Y versus their respective controls. The apparent benefit of HEYL may be mediated via improving glucoregulation and ameliorating oxidative stress and inflammation, particularly in diabetic rats.",

author = "\{Dos Santos\}, \{Klinsmann Carolo\} and Bueno, \{Bianca Guerra\} and Pereira, \{Luana Ferreira\} and Francisqueti, \{Fabiane Valentini\} and Braz, \{Mariana Gobbo\} and Bincoleto, \{Lahis Fernandes\} and \{Da Silva\}, \{Lilian Xavier\} and Ferreira, \{Ana L{\'u}cia A.\} and \{De Melo Stevanato Nakamune\}, \{Ana Cl{\'a}udia\} and Chen, \{C. Y.Oliver\} and Blumberg, \{Jeffrey B.\} and Corr{\^e}a, \{Camila Renata\}",

year = "2017",

month = jan,

day = "1",

doi = "10.1155/2017/6418048",

language = "English",

volume = "2017",

journal = "Evidence-based Complementary and Alternative Medicine",

issn = "1741-427X",

publisher = "Hindawi Limited",

}

Dos Santos, KC, Bueno, BG, Pereira, LF, Francisqueti, FV, Braz, MG, Bincoleto, LF, Da Silva, LX, Ferreira, ALA, De Melo Stevanato Nakamune, AC, Chen, CYO, Blumberg, JB & Corrêa, CR 2017, 'Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats', Evidence-based Complementary and Alternative Medicine, vol. 2017, 6418048. https://doi.org/10.1155/2017/6418048

Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats. / Dos Santos, Klinsmann Carolo; Bueno, Bianca Guerra; Pereira, Luana Ferreira et al.
In: Evidence-based Complementary and Alternative Medicine, Vol. 2017, 6418048, 01.01.2017.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats

AU - Dos Santos, Klinsmann Carolo

AU - Bueno, Bianca Guerra

AU - Pereira, Luana Ferreira

AU - Francisqueti, Fabiane Valentini

AU - Braz, Mariana Gobbo

AU - Bincoleto, Lahis Fernandes

AU - Da Silva, Lilian Xavier

AU - Ferreira, Ana Lúcia A.

AU - De Melo Stevanato Nakamune, Ana Cláudia

AU - Chen, C. Y.Oliver

AU - Blumberg, Jeffrey B.

AU - Corrêa, Camila Renata

PY - 2017/1/1

Y1 - 2017/1/1

N2 - The effects of hydroethanolic extract of Yacon leaves (HEYL) on antioxidant, glycemic, and inflammatory biomarkers were tested in diabetic rats. Outcome parameters included glucose, insulin, interleukin-6 (IL-6), and hydrophilic antioxidant capacity (HAC) in serum and IL-6, HAC, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in soleus. The rats (10/group) were divided as follows: C, controls; C + Y, HEYL treated; DM, diabetic controls; and DM + Y, diabetic rats treated with HEYL. Diabetes mellitus was induced by administration of streptozotocin. C + Y and DM + Y groups received 100 mg/kg HEYL daily via gavage for 30 d. Hyperglycemia was improved in the DM + Y versus DM group. Insulin was reduced in DM versus C group. DM rats had higher IL-6 and MDA and lower HAC in the soleus muscle. HEYL treatment decreased IL-6 and MDA and increased HAC in DM rats. DM + Y rats had the highest CAT activity versus the other groups; GPx was higher in C + Y and DM + Y versus their respective controls. The apparent benefit of HEYL may be mediated via improving glucoregulation and ameliorating oxidative stress and inflammation, particularly in diabetic rats.

AB - The effects of hydroethanolic extract of Yacon leaves (HEYL) on antioxidant, glycemic, and inflammatory biomarkers were tested in diabetic rats. Outcome parameters included glucose, insulin, interleukin-6 (IL-6), and hydrophilic antioxidant capacity (HAC) in serum and IL-6, HAC, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in soleus. The rats (10/group) were divided as follows: C, controls; C + Y, HEYL treated; DM, diabetic controls; and DM + Y, diabetic rats treated with HEYL. Diabetes mellitus was induced by administration of streptozotocin. C + Y and DM + Y groups received 100 mg/kg HEYL daily via gavage for 30 d. Hyperglycemia was improved in the DM + Y versus DM group. Insulin was reduced in DM versus C group. DM rats had higher IL-6 and MDA and lower HAC in the soleus muscle. HEYL treatment decreased IL-6 and MDA and increased HAC in DM rats. DM + Y rats had the highest CAT activity versus the other groups; GPx was higher in C + Y and DM + Y versus their respective controls. The apparent benefit of HEYL may be mediated via improving glucoregulation and ameliorating oxidative stress and inflammation, particularly in diabetic rats.

UR - https://www.scopus.com/pages/publications/85027168859

U2 - 10.1155/2017/6418048

DO - 10.1155/2017/6418048

M3 - Article

AN - SCOPUS:85027168859

SN - 1741-427X

VL - 2017

JO - Evidence-based Complementary and Alternative Medicine

JF - Evidence-based Complementary and Alternative Medicine

M1 - 6418048

ER -

Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats

Abstract

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