Zebularine induces long-term survival of pancreatic islet allotransplants in streptozotocin treated diabetic rats.

Henrietta Nittby; Peter Ericsson; Karolina Förnvik; Susanne Strömblad; Linda I Jansson; Zhongtian Xue; Gunnar Skagerberg; Bengt Widegren; Hans Olof Sjögren; Leif Salford

doi:10.1371/journal.pone.0071981

Zebularine induces long-term survival of pancreatic islet allotransplants in streptozotocin treated diabetic rats.

Henrietta Nittby, Peter Ericsson, Karolina Förnvik, Susanne Strömblad, Linda I Jansson, Zhongtian Xue, Gunnar Skagerberg, Bengt Widegren, Hans Olof Sjögren, Leif Salford

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Abstract

Coping with the immune rejection of allotransplants or autologous cells in patients with an active sensitization towards their autoantigens and autoimmunity presently necessitates life-long immune suppressive therapy acting on the immune system as a whole, which makes the patients vulnerable to infections and increases their risk of developing cancer. New technologies to induce antigen selective long-lasting immunosuppression or immune tolerance are therefore much needed.

Original language	English
Article number	e71981
Journal	PLoS ONE
Volume	8
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0071981
Publication status	Published - 2013

Subject classification (UKÄ)

Neurology
Surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0071981

Nittby_et_al

http://www.ncbi.nlm.nih.gov/pubmed/23991016?dopt=Abstract

Cite this

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title = "Zebularine induces long-term survival of pancreatic islet allotransplants in streptozotocin treated diabetic rats.",

abstract = "Coping with the immune rejection of allotransplants or autologous cells in patients with an active sensitization towards their autoantigens and autoimmunity presently necessitates life-long immune suppressive therapy acting on the immune system as a whole, which makes the patients vulnerable to infections and increases their risk of developing cancer. New technologies to induce antigen selective long-lasting immunosuppression or immune tolerance are therefore much needed.",

author = "Henrietta Nittby and Peter Ericsson and Karolina F{\"o}rnvik and Susanne Str{\"o}mblad and Jansson, {Linda I} and Zhongtian Xue and Gunnar Skagerberg and Bengt Widegren and Sj{\"o}gren, {Hans Olof} and Leif Salford",

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AU - Nittby, Henrietta

AU - Ericsson, Peter

AU - Förnvik, Karolina

AU - Strömblad, Susanne

AU - Jansson, Linda I

AU - Xue, Zhongtian

AU - Skagerberg, Gunnar

AU - Widegren, Bengt

AU - Sjögren, Hans Olof

AU - Salford, Leif

PY - 2013

Y1 - 2013

N2 - Coping with the immune rejection of allotransplants or autologous cells in patients with an active sensitization towards their autoantigens and autoimmunity presently necessitates life-long immune suppressive therapy acting on the immune system as a whole, which makes the patients vulnerable to infections and increases their risk of developing cancer. New technologies to induce antigen selective long-lasting immunosuppression or immune tolerance are therefore much needed.

AB - Coping with the immune rejection of allotransplants or autologous cells in patients with an active sensitization towards their autoantigens and autoimmunity presently necessitates life-long immune suppressive therapy acting on the immune system as a whole, which makes the patients vulnerable to infections and increases their risk of developing cancer. New technologies to induce antigen selective long-lasting immunosuppression or immune tolerance are therefore much needed.

U2 - 10.1371/journal.pone.0071981

DO - 10.1371/journal.pone.0071981

M3 - Article

C2 - 23991016

SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 8

M1 - e71981

ER -

Zebularine induces long-term survival of pancreatic islet allotransplants in streptozotocin treated diabetic rats.

Abstract

Subject classification (UKÄ)

UN SDGs

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