Zebularine induces long-term survival of pancreatic islet allotransplants in streptozotocin treated diabetic rats.

Henrietta Nittby, Peter Ericsson, Karolina Förnvik, Susanne Strömblad, Linda I Jansson, Zhongtian Xue, Gunnar Skagerberg, Bengt Widegren, Hans Olof Sjögren, Leif Salford

Research output: Contribution to journalArticlepeer-review

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Abstract

Coping with the immune rejection of allotransplants or autologous cells in patients with an active sensitization towards their autoantigens and autoimmunity presently necessitates life-long immune suppressive therapy acting on the immune system as a whole, which makes the patients vulnerable to infections and increases their risk of developing cancer. New technologies to induce antigen selective long-lasting immunosuppression or immune tolerance are therefore much needed.
Original languageEnglish
Article numbere71981
JournalPLoS ONE
Volume8
Issue number8
DOIs
Publication statusPublished - 2013

Subject classification (UKÄ)

  • Neurology
  • Surgery

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