ACE intravital imaging platform -

Anterior chamber of the eye (ACE) imaging platform

Infrastructure

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences

Type of infrastructure

  • Equipment
  • Services

Description

The ACE imaging technique makes cells or tissue optically accessible by grafting a small number of ‘reporter cells/tissue’ into the eyes of mice. The direct visualization in a variety of tissues transplanted into the ACE provides a platform to screen drugs by performing long-term follow up and monitoring in target tissues. Because of its versatility, tissue/cell transplantation into the anterior chamber of the eye benefits also other in vivo applications to study physiological and pathophysiological processes such as signal transduction, cancer, allograft-rejection or autoimmune disease development.

Equipment and resources

Custom-build instruments for transplantation
Expertise and long-term experience to perform transplantations and in vivo intravital imaging of experimental animals.

Services provided

ACE transplantation
longitudinal imaging of tissue grafts
any procedures related to experimental animals (e.g. adoptive transfer, weighing of animals etc.) upon request
image analysis upon request

Management of the infrastructure

Managed by the research group.

Available for loan

Available for loan - internal and external

Terms of access:

Free accessable to internal and external users for user fee, option for collaborations. contact in good time to check for availability