Science Translational Medicine, 1946-6242

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  1. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

    Axelsson, A. S., Tubbs, E., Mecham, B., Chacko, S., Nenonen, H. A., Tang, Y., Fahey, J. W., Derry, J. M. J., Claes B. Wollheim, Nils Wierup, Haymond, M. W., Friend, S. H., Hindrik Mulder & Anders H. Rosengren, 2017 Jun 14, In : Science Translational Medicine. 9, 394, 4477.

    Research output: Contribution to journalArticle

  2. Gene therapy for Parkinson's disease shows promise.

    Anders Björklund & Tomas Björklund, 2011, In : Science Translational Medicine. 3, 79, p. 79ed1

    Research output: Contribution to journalArticle

  3. PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer

    Bosch Campos, A., Li, Z., Bergamaschi, A., Ellis, H., Toska, E., Prat, A., Tao, J. J., Spratt, D. E., Viola-Villegas, N. T., Castel, P., Minuesa, G., Morse, N., Rodón, J., Ibrahim, Y., Cortes, J., Perez-Garcia, J., Galvan, P., Grueso, J., Guzman, M., Katzenellenbogen, J. A. & 8 others, Kharas, M., Lewis, J. S., Dickler, M., Serra, V., Rosen, N., Chandarlapaty, S., Scaltriti, M. & Baselga, J., 2015 Apr 15, In : Science Translational Medicine. 7, 283, p. 1-11 283ra51.

    Research output: Contribution to journalArticle

  4. Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus

    Clave, E., Araujo, I. L., Alanio, C., Patin, E., Bergstedt, J., Urrutia, A., Lopez-Lastra, S., Li, Y., Charbit, B., MacPherson, C. R., Hasan, M., Melo-Lima, B. L., Douay, C., Saut, N., Germain, M., Trégouët, D. A., Morange, P. E., Fontes, M., Duffy, D., Di Santo, J. & 3 others, Quintana-Murci, L., Albert, M. L. & Toubert, A., 2018 Sep 5, In : Science Translational Medicine. 10, 457, aao2966.

    Research output: Contribution to journalArticle

  5. α-Synuclein-Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons.

    Decressac, M., Kadkhodaei, B., Mattsson, B., Laguna, A., Perlmann, T. & Anders Björklund, 2012, In : Science Translational Medicine. 4, 163, p. 163ra156

    Research output: Contribution to journalArticle

  6. The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

    Deming, Y., Filipello, F., Cignarella, F., Cantoni, C., Hsu, S., Mikesell, R., Li, Z., Del-Aguila, J. L., Dube, U., Farias, F. G., Bradley, J., Budde, J., Ibanez, L., Fernandez, M. V., Blennow, K., Zetterberg, H., Heslegrave, A., Johansson, P. M., Svensson, J., Nellgård, B. & 16 others, Lleo, A., Alcolea, D., Clarimon, J., Rami, L., Molinuevo, J. L., Suárez-Calvet, M., Morenas-Rodríguez, E., Kleinberger, G., Ewers, M., Harari, O., Haass, C., Brett, T. J., Benitez, B. A., Karch, C. M., Piccio, L. & Cruchaga, C., 2019 Aug 14, In : Science Translational Medicine. 11, 505, eaau2291.

    Research output: Contribution to journalArticle

  7. mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer

    Elkabets, M., Vora, S., Juric, D., Morse, N., Mino-Kenudson, M., Muranen, T., Tao, J., Campos, A. B., Rodon, J., Ibrahim, Y. H., Serra, V., Rodrik-Outmezguine, V., Hazra, S., Singh, S., Kim, P., Quadt, C., Liu, M., Huang, A., Rosen, N., Engelman, J. A. & 2 others, Scaltriti, M. & Baselga, J., 2013 Jul 31, In : Science Translational Medicine. 5, 196, p. 1-14 196ra99.

    Research output: Contribution to journalArticle

  8. Function of an implanted tissue glucose sensor for more than 1 year in animals

    Gough, D. A., Lucas S Kumosa, Routh, T. L., Lin, J. T. & Lucisano, J. Y., 2010 Jul 28, In : Science Translational Medicine. 2, 42, p. 1-8 42ra53.

    Research output: Contribution to journalArticle

  9. Reproducible Quantification of Cancer-Associated Proteins in Body Fluids Using Targeted Proteomics

    Huttenhain, R., Soste, M., Selevsek, N., Roest, H., Sethi, A., Carapito, C., Farrah, T., Deutsch, E. W., Kusebauch, U., Moritz, R. L., Emma Niméus, Rinner, O. & Aebersold, R., 2012, In : Science Translational Medicine. 4, 142, p. 142ra94

    Research output: Contribution to journalArticle

  10. Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in diffuse large B cell lymphoma

    Jain, N., Hartert, K., Tadros, S., Fiskus, W., Havranek, O., Ma, M. C. J., Bouska, A., Heavican, T., Kumar, D., Deng, Q., Moore, D., Pak, C., Liu, C. L., Gentles, A. J., Hartmann, E., Kridel, R., Smedby, K. E., Juliusson, G., Rosenquist, R., Gascoyne, R. D. & 13 others, Rosenwald, A., Giancotti, F., Neelapu, S. S., Westin, J., Vose, J. M., Lunning, M. A., Greiner, T., Rodig, S., Iqbal, J., Alizadeh, A. A., Davis, R. E., Bhalla, K. & Green, M. R., 2019 Jun 19, In : Science Translational Medicine. 11, 497, eaav5599.

    Research output: Contribution to journalArticle

  11. The vermiform appendix impacts the risk of developing Parkinson’s disease

    Killinger, B. A., Madaj, Z., Sikora, J. W., Rey, N., Haas, A. J., Vepa, Y., Daniel Lindqvist, Chen, H., Thomas, P. M., Brundin, P., Lena Brundin & Labrie, V., 2018, In : Science Translational Medicine. 10, 465, aar5280.

    Research output: Contribution to journalArticle

  12. Transglutaminase 4 as a prostate autoantigen in male subfertility.

    Landegren, N., Sharon, D., Shum, A. K., Khan, I. S., Fasano, K. J., Hallgren, Å., Kampf, C., Freyhult, E., Ardesjö-Lundgren, B., Alimohammadi, M., Rathsman, S., Ludvigsson, J. F., Lundh, D., Motrich, R., Rivero, V., Fong, L., Giwercman, A., Gustafsson, J., Perheentupa, J., Husebye, E. S. & 3 others, Anderson, M. S., Snyder, M. & Kämpe, O., 2015, In : Science Translational Medicine. 7, 292, p. 292ra101

    Research output: Contribution to journalArticle

  13. Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson's Patients with Neural Transplants

    Politis, M., Wu, K., Loane, C., Quinn, N. P., Brooks, D. J., Rehncrona, S., Anders Björklund, Olle Lindvall & Piccini, P., 2010, In : Science Translational Medicine. 2, 38

    Research output: Contribution to journalArticle

  14. Serotonin Neuron Loss and Nonmotor Symptoms Continue in Parkinson's Patients Treated with Dopamine Grafts

    Politis, M., Wu, K., Loane, C., Quinn, N. P., Brooks, D. J., Oertel, W. H., Anders Björklund, Olle Lindvall & Piccini, P., 2012, In : Science Translational Medicine. 4, 128

    Research output: Contribution to journalArticle

  15. NCR3/NKp30 Contributes to Pathogenesis in Primary Sjogren's Syndrome

    Rusakiewicz, S., Nocturne, G., Lazure, T., Semeraro, M., Flament, C., Caillat-Zucman, S., Sene, D., Delahaye, N., Vivier, E., Chaba, K., Poirier-Colame, V., Nordmark, G., Eloranta, M-L., Eriksson, P., Theander, E., Forsblad-d'Elia, H., Omdal, R., Wahren-Herlenius, M., Jonsson, R., Ronnblom, L. & 9 others, Nititham, J., Taylor, K. E., Lessard, C. J., Sivils, K. L. M., Gottenberg, J-E., Criswell, L. A., Miceli-Richard, C., Zitvogel, L. & Mariette, X., 2013, In : Science Translational Medicine. 5, 195, p. 195ra96

    Research output: Contribution to journalArticle

  16. A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

    Scott, R. A., Freitag, D. F., Li, L., Chu, A. Y., Surendran, P., Young, R., Grarup, N., Stancáková, A., Chen, Y., Varga, T. V., Yaghootkar, H., Luan, J., Zhao, J. H., Willems, S. M., Wessel, J., Wang, S., Maruthur, N., Michailidou, K., Pirie, A., Van Der Lee, S. J. & 118 others, Gillson, C., Al Olama, A. A., Amouyel, P., Arriola, L., Arveiler, D., Aviles-Olmos, I., Balkau, B., Barricarte, A., Barroso, I., Garcia, S. B., Bis, J. C., Blankenberg, S., Boehnke, M., Boeing, H., Boerwinkle, E., Borecki, I. B., Bork-Jensen, J., Bowden, S., Caldas, C., Caslake, M., Cupples, L. A., Cruchaga, C., Czajkowski, J., Den Hoed, M., Dunn, J. A., Earl, H. M., Ehret, G. B., Ferrannini, E., Ferrieres, J., Foltynie, T., Ford, I., Forouhi, N. G., Gianfagna, F., Gonzalez, C., Grioni, S., Hiller, L., Jansson, J. H., Jørgensen, M. E., Jukema, J. W., Kaaks, R., Kee, F., Kerrison, N. D., Key, T. J., Kontto, J., Kote-Jarai, Z., Kraja, A. T., Kuulasmaa, K., Kuusisto, J., Linneberg, A., Liu, C., Marenne, G., Mohlke, K. L., Morris, A. P., Muir, K., Müller-Nurasyid, M., Munroe, P. B., Navarro, C., Nielsen, S. F., Peter M. Nilsson, Nordestgaard, B. G., Packard, C. J., Palli, D., Panico, S., Peloso, G. M., Perola, M., Peters, A., Poole, C. J., Quirós, J. R., Rolandsson, O., Sacerdote, C., Salomaa, V., Sánchez, M. J., Sattar, N., Sharp, S. J., Sims, R., Slimani, N., Smith, J. A., Thompson, D. J., Trompet, S., Tumino, R., Van Der A, D. L., Van Der Schouw, Y. T., Virtamo, J., Walker, M., Walter, K., Abraham, J. E., Amundadottir, L. T., Butterworth, A. S., Aponte, J. L., Dupuis, J., Easton, D. F., Eeles, R. A., Erdmann, J., Paul W. Franks, Frayling, T. M., Hansen, T., Howson, J. M. M., Jørgensen, T., Kooner, J., Laakso, M., McCarthy, M. I., Pankow, J. S., Pedersen, O., Riboli, E., Rotter, J. I., Saleheen, D., Samani, N. J., Schunkert, H., Vollenweider, P., O'Rahilly, S., Deloukas, P., Danesh, J., Goodarzi, M. O., Kathiresan, S., Meigs, J. B., Ehm, M. G., Wareham, N. J. & Waterworth, D. M., 2016 Jun 1, In : Science Translational Medicine. 8, 341, 341ra76.

    Research output: Contribution to journalArticle

  17. Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist.

    Tang, Y., Axelsson, A., Peter Spégel, Andersson, L., Hindrik Mulder, Leif Groop, Erik Renström & Anders Rosengren, 2014, In : Science Translational Medicine. 6, 257, p. 257ra139

    Research output: Contribution to journalArticle

  18. Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

    Thorek, D. L. J., Watson, P. A., Lee, S. G., Ku, A. T., Bournazos, S., Braun, K., Kim, K., Sjostrom, K., Doran, M. G., Lamminmaki, U., Santos, E., Veach, D., Turkekul, M., Casey, E., Lewis, J. S., Abou, D. S., Van Voss, M. R. H., Scardino, P. T., Strand, S. E., Alpaugh, M. L. & 4 others, Scher, H. I., Hans Lilja, Larson, S. M. & David Ulmert, 2016 Nov 30, In : Science Translational Medicine. 8, 367, 367ra167.

    Research output: Contribution to journalArticle