Aneuploidy in cancer

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Hematology

Keywords

  • Leukemia, high hyperdiploid, anaplastic thyroid, cancer genomics, aneuploidy, hypodiploidy

Description

Research

We use molecular genetic techniques such as next-generation sequencing and SNP array analysis to identify and characterize acquired genetic aberrations in aneuploid malignancies, with a particular focus on high hyperdiploid and hypodiploid acute lymphoblastic leukemia and anaplastic thyroid cancer. Primary aim To understand how massive chromosomal gain and loss arise and affect cancer cells. Secondary aim To identify novel treatment-stratifying markers and new therapeutic targets in aneuploid malignancies.

Recent research outputs

Minjun Yang, Vesterlund, M., Siavelis, I., Moura-Castro, L. H., Anders Castor, Thoas Fioretos, Jafari, R., Henrik Lilljebjörn, Odom, D. T., Linda Olsson, Naveen Ravi, Eleanor L. Woodward, Harewood, L., Lehtiö, J. & Kajsa Paulsson, 2019 Apr 3, In : Nature Communications. 10, 1, 1519.

Research output: Contribution to journalArticle

Ola Forslund, Natsuki Sugiyama, Chengjun Wu, Naveen Ravi, Jin, Y., Swoboda, S., Andersson, F., Bzhalava, D., Hultin, E., Kajsa Paulsson, Dillner, J., Stefan Schwartz, Johan Wennerberg & Lars Ekblad, 2019 Mar 25, In : BMC Cancer. 19, 1, 265.

Research output: Contribution to journalArticle

Naveen Ravi, Minjun Yang, Sigurdur Gretarsson, Jansson, C., Mylona, N., Sydow, S. R., Eleanor L. Woodward, Lars Ekblad, Johan Wennerberg & Kajsa Paulsson, 2019 Mar 22, In : Cancers. 11, 3, 402.

Research output: Contribution to journalArticle

View All (17)