Basal Ganglia Pathophysiology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Neurosciences

Keywords

  • Experimental medicine, translational medicine, neurodegenerative diseases, movement disorders

Description

The basal ganglia are a group of interconnected brain nuclei involved in action control. Loss or dysfunction of neurons within the basal ganglia cause some typical motor symptoms, such as poverty of movement (akinesia) or abnormal involuntary movements (dyskinesia). Parkinson´s disease (PD; prevalence ~ 1% in the population over 55 years of age) is the most common neurodegenerative disease affecting the basal ganglia. The typical lesion in PD consists in a loss of dopamine neurons that are located in the substantia nigra. Pharmacological dopamine replacement with L-DOPA remains the most effective treatment for PD. However, this treatment causes severe long-term complications, such as dyskinesia (abnormal involuntary movements). Novel treatment strategies for PD, such as intracerebral neural transplants, can also cause disabling dyskinesias.

Research

Our research explores molecular and cellular plasticity in the basal ganglia after damage and/or pharmacological treatment. Our major lines of investigation address the mechanisms of symptom progression and treatment-related dyskinesias in rodent models of Parkinson´s disease. These studies take advantage of articulate behavioural testing routines for rats and mice that we have developed. We are currently studying the role of specific signaling molecules and transcription factors in L-DOPA-induced dyskinesia. We are also studying changes in transmitter release in the basal ganglia in rats that develop dyskinesia following intrastriatal neural transplants and/or chronic treatment with L-DOPA. We are further evaluating the therapeutic potential of novel pharmacological agents that act on non-dopaminergic receptor systems. Our research will contribute to the development of novel therapies for Parkinson´s Disease and other disorders of the basal ganglia.

Recent research outputs

Hauser, R. A., Eidelberg, D., Pahwa, R., Riggare, S. & M. Angela Cenci, 2020 May, In : Movement Disorders. 35, 5, p. 901-901 1 p.

Research output: Contribution to journalLetter

Anders Björklund & M. Angela Cenci, 2020 Apr 1, Recent Advances in Parkinson's Disease. Björklund, A. & Cenci, M. A. (eds.). 1 ed. Elsevier Science Publishers B.V., p. xix-xx 2 p. (Progress in Brain Research; vol. 252).

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Irene Sebastianutto, Goyet, E., Andreoli, L., Font-Ingles, J., Moreno-Delgado, D., Bouquier, N., Jahannault-Talignani, C., Moutin, E., Di Menna, L., Maslava, N., Pin, J. P., Fagni, L., Nicoletti, F., Ango, F., M. Angela Cenci & Perroy, J., 2020 Mar 2, In : Journal of Clinical Investigation. 130, 3, p. 1168-1184

Research output: Contribution to journalArticle

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