Bone marrow stem cells and cellular therapies

Organisational unit: Research group

Research areas and keywords

Keywords

  • stem cells, bone marrow stroma, hematopoiesis, cell therapy

Description

Research

The major focus of our research is to study bone marrow hematopoietic and stromal stem cells and their crosstalk in healthy and diseased bone marrow, aiming to develop therapies to repair or eliminate and replace dysfunctional HSCs and BMSCs, thus leading to improved therapies for patients with hematological malignancies. Malignant HSC can be replaced by transplantation of healthy donor stem cells (so-called hematopoietic stem cell transplantation, HSCT), which is the only curative treatment for patients with high-risk hematological malignancies. However, HSCT is a potentially dangerous procedure with severe side-effects which cause a considerable treatment-related morbidity and mortality. Therefore, another major line of research in our lab focuses on the development of novel novel and improved stem cell collection and separation technologies and transplantation biomarker assays based on acoustic sorting (acoustophoresis).

Recent research outputs

Petersson, K., Jakobsson, O., Pelle Ohlsson, Per Augustsson, Stefan Scheding, Johan Malm & Thomas Laurell, 2018, In : Analytica Chimica Acta. 1000, p. 199-204

Research output: Contribution to journalArticle

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