Breast cancer prevention & intervention

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Breast cancer

Research

Breast cancer is the most common cancer in women worldwide with a steady increase in the number diagnosed. Comparable to this increased incidence, obesity is a pressing public health concern and the positive association between a more obese body constitution on breast cancer risk has convincingly been demonstrated. Obesity associated alterations in circulating lipids/cholesterol might partly link the association between obesity and breast cancer. However, the epidemiological linkage remains poorly understood. Interestingly, cholesterol-lowering statins have received substantial attention in the field of cancer research. So far, statins have been shown to decrease proliferation and increase apoptosis of breast cancer cells. These effects need verification in the clinical setting. Further, no studies have investigated the effects in normal breast cells, which is of foremost importance to understand the potential role of statins in breast cancer initiation and thus prevention.

Recent research outputs

Mikael Eriksson, Martin Eklund, Signe Borgquist, Roxanna Hellgren, Sara Margolin, Linda Thoren, Ann Rosendahl, Kristina Lång, José Tapia, Magnus Bäcklund, Andrea Discacciati, Alessio Crippa, Marike Gabrielson, Mattias Hammarström, Yvonne Wengström, Kamila Czene & Per Hall, 2021 Mar 18, In: Journal of Clinical Oncology. JCO2002598.

Research output: Contribution to journalArticle

Michèle Matta, Inge Huybrechts, Carine Biessy, Corinne Casagrande, Sahar Yammine, Agnès Fournier, Karina Standahl Olsen, Marco Lukic, Inger Torhild Gram, Eva Ardanaz, Maria José Sánchez, Laure Dossus, Renée T. Fortner, Bernard Srour, Franziska Jannasch, Matthias B. Schulze, Pilar Amiano, Antonio Agudo, Sandra Colorado-Yohar, J. Ramón Quirós & 18 others, Rosario Tumino, Salvatore Panico, Giovanna Masala, Valeria Pala, Carlotta Sacerdote, Anne Tjønneland, Anja Olsen, Christina C. Dahm, Ann H. Rosendahl, Signe Borgquist, Maria Wennberg, Alicia K. Heath, Dagfinn Aune, Julie Schmidt, Elisabete Weiderpass, Veronique Chajes, Marc J. Gunter & Neil Murphy, 2021, In: BMC Medicine. 19, 1, 81.

Research output: Contribution to journalArticle

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