Cancer and matrix remodelling

Organisational unit: Research group

Description

Research

Metastasis is responsible for over 90% of cancer-related deaths. In order for cancer cells to spread, they need to adapt to the environment they encounter. Our research aims to understand how cancer cells navigate cancer remodelled extracellular matrix (ECM) and how changes in ECM composition and topology can drive tumorigenesis. We recently discovered a complex, called the STRIPAK complex, to be an important and ancient regulator of ‘plasticity of cell migration’, in both developmental processes and breast cancer metastasis. We believe this complex regulate cell shape changes needed to invade obstacles of different topology. We will continue to target the STRIPAK complex, as a potential new anti-metastatic strategy. Our work is multidisciplinary and we take advantage of various imaging modalities to understand cancer cell migration and ECM remodelling in real time including 2-photon microscopy and multispectral optoacoustic tomography (MSOT).

Recent research outputs

Alejandro E Mayorca-guiliani, Maria Rafaeva, Oliver Willacy, Chris Madsen, Raphael Reuten & Janine T. Erler, 2021 May 30, In: Journal of visualized experiments : JoVE.

Research output: Contribution to journalArticle

Freja Albjerg Venning, Kamilla Westarp Zornhagen, Lena Wullkopf, Jonas Sjölund, Carmen Rodriguez-Cupello, Pontus Kjellman, Mikkel Morsing, Morteza Chalabi Hajkarim, Kyoung Jae Won, Janine Terra Erler & Chris Denis Madsen, 2021 May 20, In: Journal of Experimental and Clinical Cancer Research. 40, 1, p. 1 21 p., 175.

Research output: Contribution to journalArticle

Chris Madsen, 2021 Mar 11, In: Cancer Cell.

Research output: Contribution to journalReview article

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