Cardiovascular Research - Hypertension

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cardiac and Cardiovascular Systems
  • Endocrinology and Diabetes
  • Medical Genetics
  • Family Medicine
  • Physiology

Keywords

  • CVD, hypertension

Description

We aim to identify novel interventions for prevention and treatment of diabetes-related cardiovascular disease (CVD). Our strategy is to identify genetic, endocrine and metabolic disturbances in humans which are causally related to disease development and are detectable many years before disease presents. We then test in both animals and in human intervention studies if manipulation of such molecular disturbances ameliorate cardiometabolic risk. A few examples of our translational research achievements include discovery of: (1) CVD genetic risk variants which identify “hidden high-risk individuals” in the population and specific pharmacological and life-style treatments which can revert that genetic risk, (2) neurotensin as a key hormone linking hyper-efficient intestinal fat absorption and storage to obesity, diabetes and CVD development and (3) high vasopressin secretion as a cause of diabetes and CVD and the potential of increased water intake to revert the risk.

Recent research outputs

Jansen van Vuren, E., Malan, L., von Känel, R., Martin Magnusson, Lammertyn, L. & Malan, N. T., 2019 Apr 1, In : European Journal of Clinical Investigation. e13116.

Research output: Contribution to journalArticle

Rowland, C. M., Shiffman, D., Caulfield, M., Garcia, V., Olle Melander & Hastie, T., 2019 Mar 7, In : PLoS ONE. 14, 3, e0213172.

Research output: Contribution to journalArticle

Patti, G., Sticchi, A., Pasceri, V., Fabrizio Ricci, Renda, G., Viktor Hamrefors, Olle Melander, Sutton, R., Gunnar Engström, De Caterina, R. & Artur Fedorowski, 2019 Feb 21, In : Diabetes/Metabolism Research and Reviews. p. 1-9

Research output: Contribution to journalArticle

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