Chemical Biology and Therapeutics

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Pharmaceutical Sciences
  • Pharmacology and Toxicology
  • Medicinal Chemistry
  • Neurosciences
  • Organic Chemistry
  • Biomaterials Science
  • Nano Technology

Description

eNeuropharmacology, electroceuticals for the nervous system. In this project the ambition is to supplement biochemical signaling with electronic functionalities. Traditional medicines are based on the biochemical principles without regard to the electrical properties. We focus on organic electronics that are self-assembled directly inside or in the vicinity of the nervous system, to form electronic circuits that mimic the structure and organization of the nervous system, so that the nervous system can be seamlessly integrated. As primary models for these studies we use locust and zebrafish, with focus on brain disorders, spinal cord injuries, and regenerative medicine.

Research

Neuropharmacology using in-vivo response profiles of drugs. Current psychiatric diagnoses are scientifically challenging to use as tools to identify discrete mental health disorders, and thus for the discovery of efficient drugs for brain disorders. We focus on the profiling of discrete behavioral domains, which can then be added together in different ratios to represent a psychiatric diagnosis for an individual patient. Using artificial neural networks, we aim to identify combinations of drugs for individual patients. The complexity of the brain makes it difficult to predict how combinations of drugs will affect behaviour (psychiatric symptoms) without direct testing in live animals. We use zebrafish, which is probably one of the few species that realistically (ethically and economically) makes it possible to perform behavioural experiments on the necessary scale.

Recent research outputs

Siva, K., Fredrik Ek, Jun Chen, Abdul Ghani Alattar, Sigmundsson, K., Roger Olsson, Wlodarski, M., Lundbäck, T. & Johan Flygare, 2019, In : SLAS discovery : advancing life sciences R & D. 24, 3, p. 304-313 10 p.

Research output: Contribution to journalArticle

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