Chemical Biology and Therapeutics

Organisational unit: Research group

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  1. 2019
  2. A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia

    Siva, K., Fredrik Ek, Chen, J., Abdul Ghani Alattar, Sigmundsson, K., Roger Olsson, Wlodarski, M., Lundbäck, T. & Johan Flygare, 2019, In : SLAS discovery : advancing life sciences R & D. 24, 3, p. 304-313 10 p.

    Research output: Contribution to journalArticle

  3. 2018
  4. Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity

    Freiburghaus, C., Venera Kuci Emruli, Johansson, A., Eskelund, C. W., Grønbæk, K., Roger Olsson, Fredrik Ek, Mats Jerkeman & Sara Ek, 2018 Apr 25, In : BMC Cancer. 18, 1, 466.

    Research output: Contribution to journalArticle

  5. Osmotic Concentration of Zebrafish (Danio rerio) Body Fluids is Lower in Larvae than in Adults

    Kozłowski, T. M., Jönsson, M., Fredrik Ek, Roger Olsson & Ronald H H Kröger, 2018 Feb 1, In : Zebrafish. 15, 1, p. 9 -14 6 p.

    Research output: Contribution to journalArticle

  6. 2017
  7. Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization

    Scheepstra, M., Andrei, S. A., De Vries, R. M. J. M., Meijer, F. A., Ma, J-N., Burstein, E. S., Roger Olsson, Ottmann, C., Milroy, L. G. & Brunsveld, L., 2017 Sep 20, In : ACS Chemical Neuroscience. 8, 9, p. 2065-2077 13 p.

    Research output: Contribution to journalArticle

  8. Reporting on methods to generate and purify rodent and human oligodendrocytes from different sources

    Djelloul, M., Carla Azevedo, Yuriy Pomeshchik, Hammarberg, A. & Laurent Roybon, 2017 Apr 1, In : Stem Cell Research. 20, p. 58-66 9 p.

    Research output: Contribution to journalArticle

  9. 2016
  10. Regio- and Stereoselective Alkylation of Pyridine-N-oxides: Synthesis of Substituted Piperidines and Pyridines

    Barange, D. K., Magnus T. Johnson, Cairns, A. G., Roger Olsson & Almqvist, F., 2016 Dec 16, In : Organic Letters. 18, 24, p. 6228-6231 4 p.

    Research output: Contribution to journalArticle

  11. Effects of acute and chronic stress on telencephalic neurochemistry and gene expression in rainbow trout (Oncorhynchus mykiss)

    Moltesen, M., Laursen, D. C., Thörnqvist, P. O., Andersson, M. Å., Winberg, S. & Höglund, E., 2016 Dec 15, In : Journal of Experimental Biology. 219, 24, p. 3907-3914 8 p.

    Research output: Contribution to journalArticle

  12. Small molecules increase direct neural conversion of human fibroblasts

    Pfisterer, U., Fredrik Ek, Lang, S., Shamit Soneji, Roger Olsson & Malin Parmar, 2016 Dec 5, In : Scientific Reports. 6, 38290.

    Research output: Contribution to journalArticle

  13. Estrogen Receptor Beta Selective Agonists as Agents to Treat Chemotherapeutic-Induced Neuropathic Pain

    Ma, J. N., McFarland, K., Roger Olsson & Burstein, E. S., 2016 Sep 21, In : ACS Chemical Neuroscience. 7, 9, p. 1180-1187 8 p.

    Research output: Contribution to journalArticle

  14. Behavioral Analysis of Dopaminergic Activation in Zebrafish and Rats Reveals Similar Phenotypes

    Fredrik Ek, Malo, M., Åberg Andersson, M., Wedding, C., Kronborg, J., Svensson, P., Waters, S., Per Petersson & Roger Olsson, 2016 May 18, In : ACS Chemical Neuroscience. 7, 5, p. 633-46 14 p.

    Research output: Contribution to journalArticle

  15. An ex Vivo Model for Evaluating Blood-Brain Barrier Permeability, Efflux, and Drug Metabolism.

    Karin Hellman, Aadal Nielsen, P., Fredrik Ek & Roger Olsson, 2016, In : ACS Chemical Neuroscience. 7, 5, p. 668-680 13 p.

    Research output: Contribution to journalArticle

  16. Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.

    Sundén, H., Schäfer, A., Scheepstra, M., Leysen, S., Malo, M., Ma, J-N., Burstein, E. S., Ottmann, C., Brunsveld, L. & Roger Olsson, 2016, In : Journal of Medicinal Chemistry. 59, 3, p. 1232-1238

    Research output: Contribution to journalArticle

  17. 2015
  18. Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors.

    Holmqvist, S., Brouwer, M., Djelloul, M., Diaz, A. G., Devine, M. J., Hammarberg, A., Fog, K., Kunath, T. & Laurent Roybon, 2015, In : Stem Cell Research. 15, 1, p. 203-220

    Research output: Contribution to journalArticle

  19. Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor Modulators

    Sunden, H., Holland, M. C., Poutiainen, P. K., Jaaskelainen, T., Pulkkinen, J. T., Palvimo, J. J. & Roger Olsson, 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1569-1574

    Research output: Contribution to journalArticle

  20. Therapeutic Targeting of Nuclear Gamma-Tubulin in RB1-negative Tumors.

    Lindström, L., Villoutreix, B. O., Sophie Lehn, Rebecka Hellsten, Nilsson, E., Crneta, E., Roger Olsson & Maria Alvarado-Kristensson, 2015, In : Molecular Cancer Research. 13, 7, p. 1073-1082

    Research output: Contribution to journalArticle

  21. Using visual lateralization to model learning and memory in zebrafish larvae.

    Åberg Andersson, M., Fredrik Ek & Roger Olsson, 2015, In : Scientific Reports. 5, 8667.

    Research output: Contribution to journalArticle

  22. 2014
  23. Apicidin Sensitizes Pancreatic Cancer Cells to Gemcitabine by Epigenetically Regulating MUC4 Expression.

    Daniel Ansari, Urey, C., Said Hilmersson, K., Bauden, M., Fredrik Ek, Roger Olsson & Roland Andersson, 2014, In : Anticancer research. 34, 10, p. 5269-5276

    Research output: Contribution to journalArticle

  24. Bexarotene prodrugs: Targeting through cleavage by NQO1 (DT-diaphorase).

    Schäfer, A., Burstein, E. S. & Roger Olsson, 2014, In : Bioorganic & Medicinal Chemistry Letters. 24, 8, p. 1944-1947

    Research output: Contribution to journalArticle

  25. 2013
  26. AC-186, a Selective Nonsteroidal Estrogen Receptor beta Agonist, Shows Gender Specific Neuroprotection in a Parkinson's Disease Rat Model

    McFarland, K., Price, D. L., Davis, C. N., Ma, J-N., Bonhaus, D. W., Burstein, E. S. & Roger Olsson, 2013, In : ACS Chemical Neuroscience. 4, 9, p. 1249-1255

    Research output: Contribution to journalArticle

  27. Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson's Disease

    McFarland, K., Spalding, T. A., Hubbard, D., Ma, J-N., Roger Olsson & Burstein, E. S., 2013, In : ACS Chemical Neuroscience. 4, 11, p. 1430-1438

    Research output: Contribution to journalArticle

  28. The A-CD analogue of 16 beta,17 alpha-estriol is a potent and highly selective estrogen receptor beta agonist

    Sauvee, C., Schafer, A., Sunden, H., Ma, J-N., Gustavsson, A-L., Burstein, E. S. & Roger Olsson, 2013, In : MedChemComm. 4, 11, p. 1439-1442

    Research output: Contribution to journalArticle

  29. 2004
  30. Evaluation of two pairs of chiral stationary phases: Effects from the length of the achiral spacers

    Thunberg, L., Allenmark, S., Friberg, A., Fredrik Ek & Torbjörn Frejd, 2004, In : Chirality. 16, 9, p. 614-624

    Research output: Contribution to journalArticle

  31. 2003
  32. Synthesis of Fused Tertazole- and Imidazole Derivatives via Iodocyclization.

    Fredrik Ek, Wistrand, L-G. & Torbjörn Frejd, 2003, In : Tetrahedron. 59, 35, p. 6759-6769

    Research output: Contribution to journalArticle

  33. 2002
  34. Aromatic allylation via diazotization: Metal-free C-C bond formation

    Fredrik Ek, Axelsson, O., Wistrand, LG. & Torbjörn Frejd, 2002, In : Journal of Organic Chemistry. 67, 18, p. 6376-6381

    Research output: Contribution to journalArticle