Cystatin C, renal disease, amyloidosis and antibiotics

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Clinical Laboratory Medicine
  • Medicinal Chemistry
  • Urology and Nephrology

Keywords

  • Amyloidosis, antibiotics, cerebral haemorrhage, creatinine, cystatin C, cystatins, eGFR, estimated GFR, GFR, glomerular filtration rate, kidney, renal

Description

Research

We have described the structure and function of human cystatin C and its gene. We have shown that the plasma level of cystatin C is the best marker for glomerular filtration rate, GFR, and that a new disorder, “Shrunken-Pore-Syndrome”, with a high prevalence and a very high mortality, can be identified my measuring cystatin C. We are studying the pathophysiology of the disorder and how to treat it. We have determined the mechanism by which a mutation in the cystatin C gene causes an amyloid deposition of the protein in brain arteries producing brain hemorrhage in young adults. The mechanism is similar to that occurring in other common amyloid disorders, e.g, Alzhemier´s and Parkinson´s disease. We develop substances interfering in this mechanism. We have produced new antibacterial and antiviral substances, based upon the structure of cystatin C, and continue to improve them. Some of the substances are active against bacterial strains resistent towards all presently available antibiotics.

Recent research outputs

Jonas Björk, Ulf Nyman, Pierre Delanaye, Anders Grubb, Anders Larsson, Laura Vranken, Anna Åkesson & Hans Pottel, 2020 Jul 6, In : Scandinavian Journal of Clinical and Laboratory Investigation.

Research output: Contribution to journalArticle

Jonas Björk, Ulf Nyman, Marie Courbebaisse, Lionel Couzi, R Neil Dalton, Laurence Dubourg, Natalie Ebert, Bjørn Odvar Eriksen, Francois Gaillard, Cyril Garrouste, Anders Grubb, Magnus Hansson, Lola Jacquemont, Ian Jones, Nassim Kamar, Edmund J. Lamb, Christophe Legendre, Karin Littmann, Christophe Mariat, Toralf Melsom & 8 others, Lionel Rostaing, Andrew D. Rule, Elke Schaeffner, Per-Ola Sundin, Stephen Turner, Anna Åkesson, Pierre Delanaye & Hans Pottel, 2020 Jun 13, In : CKJ: Clinical Kidney Journal. 13, 4, p. 674-683 10 p.

Research output: Contribution to journalArticle

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