Developmental and Regenerative Neurobiology

Organisational unit: Research group

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  1. 2019
  2. FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes

    Ekaterina Savchenko, Teku, G. N., Antonio Boza-Serrano, Kaspar Russ, Berns, M., Tomas Deierborg, Lamas, N. J., Wichterle, H., Rothstein, J., Henderson, C. E., Mauno Vihinen & Laurent Roybon, 2019 Jul 3, In : Scientific Reports. 9, 1, 9610.

    Research output: Contribution to journalArticle

  3. Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease

    TRANSEURO consortium, Barker, R. A., Farrell, K., Guzman, N. V., He, X., Lazic, S. E., Moore, S., Morris, R., Tyers, P., Wijeyekoon, R., Daft, D., Hewitt, S., Dayal, V., Foltynie, T., Kefalopoulou, Z., Mahlknecht, P., Lao-Kaim, N. P., Piccini, P., Bjartmarz, H., Björklund, A. & 13 othersOlle Lindvall, Jenny Nelander-Wahlestedt, Malin Parmar, Gesine Paul, Hakan Widner, Church, A., Dunnett, S., Peall, K., Rosser, A., Gurruchaga, J. M., Palfi, S., Piroth, T. & Winkler, C., 2019 Jul, In : Nature Medicine. 25, p. 1045–1053 9 p.

    Research output: Contribution to journalArticle

  4. Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease

    Carl Rosenblad, Li, Q., Pioli, E. Y., Dovero, S., Antunes, A. S. L. M., Agúndez, L., Bardelli, M., Linden, R. M., Henckaerts, E., Anders Björklund, Bezard, E. & Tomas Björklund, 2019 Jun 26, In : Brain : a journal of neurology.

    Research output: Contribution to journalArticle

  5. Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development

    Tiklová, K., Björklund, Å. K., Lahti, L., Alessandro Fiorenzano, Sara Nolbrant, Gillberg, L., Volakakis, N., Yokota, C., Hilscher, M. M., Hauling, T., Holmström, F., Joodmardi, E., Nilsson, M., Malin Parmar & Perlmann, T., 2019 Feb 4, In : Nature Communications. 10, 1, 581.

    Research output: Contribution to journalArticle

  6. Botulinum and tetanus neurotoxins

    Dong, M., Masuyer, G. & Pål Stenmark, 2019, In : Annual Review of Biochemistry. 88, p. 811-837 27 p.

    Research output: Contribution to journalReview article

  7. Cell-based therapy for Parkinson's disease: A journey through decades toward the light side of the Force

    Malin Parmar, Torper, O. & Drouin-Ouellet, J., 2019, In : European Journal of Neuroscience. 49, 4, p. 463-471

    Research output: Contribution to journalArticle

  8. Long non-coding RNA in stem cell pluripotency and lineage commitment: functions and evolutionary conservation

    Fico, A., Alessandro Fiorenzano, Pascale, E., Patriarca, E. J. & Minchiotti, G., 2019, In : Cellular and Molecular Life Sciences. 76, 8, p. 1459-1471

    Research output: Contribution to journalArticle

  9. Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform

    Stacey, G. N., Andrews, P. W., Barbaric, I., Boiers, C., Chandra, A., Cossu, G., Csontos, L., Frith, T. J., Halliwell, J. A., Hewitt, Z., McCall, M., Moore, H. D., Malin Parmar, Panico, M. B., Pisupati, V., Shichkin, V. P., Stacey, A. R., Tedesco, F. S., Thompson, O. & Wagey, R., 2019, In : Regenerative Medicine. 14, 3, p. 243-255

    Research output: Contribution to journalArticle

  10. 2018
  11. Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson’s disease

    Faustini, G., Longhena, F., Varanita, T., Bubacco, L., Pizzi, M., Missale, C., Benfenati, F., Anders Björklund, Spano, P. F. & Bellucci, A., 2018 Oct 1, In : Acta Neuropathologica. 136, 4, p. 621-639 19 p.

    Research output: Contribution to journalArticle

  12. Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation

    Karolina Pircs, Petri, R., Madsen, S., Per Ludvik Brattås, Vuono, R., Daniella R. Ottosson, St-Amour, I., Hersbach, B. A., Matusiak-Brückner, M., Lundh, S. H., Åsa Petersén, Déglon, N., Hébert, S. S., Malin Parmar, Barker, R. A. & Johan Jakobsson, 2018 Aug, In : Cell Reports. 24, 6, p. 1397-1406 10 p.

    Research output: Contribution to journalArticle

  13. The serotonergic system in L-DOPA-induced dyskinesia: pre-clinical evidence and clinical perspective

    Carta, M. & Anders Björklund, 2018 Aug, In : Journal of Neural Transmission. 125, 8, p. 1195-1202

    Research output: Contribution to journalArticle

  14. New approaches for brain repair-from rescue to reprogramming

    Barker, R. A., Götz, M. & Malin Parmar, 2018 May, In : Nature. 557, 7705, p. 329-334

    Research output: Contribution to journalReview article

  15. Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts

    Shelby Shrigley, Karolina Pircs, Barker, R. A., Malin Parmar & Drouin-ouellet, J., 2018 Feb 5, In : Journal of Visualized Experiments. 132, e56904.

    Research output: Contribution to journalArticle

  16. Towards stem cell based therapies for parkinson’s disease

    Malin Parmar, 2018 Jan 1, In : Development (Cambridge). 145, 1, dev156117.

    Research output: Contribution to journalArticle

  17. Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum

    Aldrin-Kirk, P., Andreas Heuer, Rylander Ottosson, D., Marcus Davidsson, Mattsson, B. & Tomas Björklund, 2018 Jan, In : Neurobiology of Disease. 109, p. 148-162

    Research output: Contribution to journalArticle

  18. Cell Replacement Therapy for Parkinson's Disease: Potential for Circuitry Repair

    Tiago Cardoso, 2018, Lund: Lund University, Faculty of Medicine. 92 p.

    Research output: ThesisDoctoral Thesis (compilation)

  19. Dermal fibroblasts from patients with Parkinson's disease have normal GCase activity and autophagy compared to patients with PD and GBA mutations

    Collins, L. M., Drouin-Ouellet, J., Kuan, W. L., Cox, T. & Barker, R. A., 2018, In : F1000Research. 6, 1751.

    Research output: Contribution to journalArticle

  20. In vivo electrochemical studies of optogenetic control of glutamate signaling measured using enzyme-based ceramic microelectrode arrays

    Burmeister, J. J., Pomerleau, F., Quintero, J. E., Huettl, P., Ai, Y., Johan Jakobsson, Lundblad, M., Andreas Heuer, Slevin, J. T. & Gerhardt, G. A., 2018, Neuromethods. Humana Press, Vol. 130. p. 327-351 25 p. (Neuromethods; vol. 130).

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  21. Repairing the brain: Cell replacement using stem cell-based technologies

    Henchcliffe, C. & Malin Parmar, 2018, In : Journal of Parkinson's Disease. 8, s1, p. S131-S137

    Research output: Contribution to journalReview article

  22. 2017
  23. Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus

    Avaliani, N., Pfisterer, U., Andreas Heuer, Malin Parmar, Merab Kokaia & My Andersson, 2017 Nov 26, In : Stem Cells International. 2017, 9 p., 5718608.

    Research output: Contribution to journalArticle

  24. Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era

    Barker, R. A., Malin Parmar, Studer, L. & Takahashi, J., 2017 Nov 2, In : Cell Stem Cell. 21, 5, p. 569-573 5 p.

    Research output: Contribution to journalDebate/Note/Editorial

  25. Direct neuronal reprogramming for disease modeling studies using patient-derived neurons: What have we learned?

    Drouin-Ouellet, J., Karolina Pircs, Barker, R. A., Johan Jakobsson & Malin Parmar, 2017 Sep 28, In : Frontiers in Neuroscience. 11, SEP, 530.

    Research output: Contribution to journalReview article

  26. Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain

    Thakur, P., Breger, L. S., Lundblad, M., Wan, O. W., Mattsson, B., Luk, K. C., Lee, V. M. Y., Trojanowski, J. Q. & Anders Björklund, 2017 Sep 26, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 39, p. E8284-E8293

    Research output: Contribution to journalArticle

  27. Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model

    Kikuchi, T., Morizane, A., Doi, D., Magotani, H., Onoe, H., Hayashi, T., Mizuma, H., Takara, S., Takahashi, R., Inoue, H., Morita, S., Yamamoto, M., Okita, K., Nakagawa, M., Malin Parmar & Takahashi, J., 2017 Aug 30, In : Nature. 548, 7669, p. 592-596 5 p.

    Research output: Contribution to journalLetter

  28. Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli

    Tornero, D., Tsupykov, O., Granmo, M., Rodriguez-Fontenla, C., Grønning-Hansen, M., Jonas Thelin, Smozhanik, E., Laterza, C., Wattananit, S., Ge, R., Tatarishvili, J., Shane Grealish, Brüstle, O., Skibo, G., Malin Parmar, Jens Schouenborg, Olle Lindvall & Zaal Kokaia, 2017 Mar 1, In : Brain. 140, 3, p. 692-706 15 p.

    Research output: Contribution to journalArticle

  29. Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease

    Agnete Kirkeby, Sara Nolbrant, Tiklova, K., Andreas Heuer, Kee, N., Tiago Cardoso, Daniella Rylander Ottosson, Lelos, M. J., Rifes, P., Dunnett, S. B., Shane Grealish, Perlmann, T. & Malin Parmar, 2017 Jan 5, In : Cell Stem Cell. 20, 1, p. 135-148 14 p.

    Research output: Contribution to journalArticle

  30. Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages

    Kee, N., Volakakis, N., Agnete Kirkeby, Dahl, L., Storvall, H., Sara Nolbrant, Lahti, L., Björklund, Å. K., Gillberg, L., Joodmardi, E., Sandberg, R., Malin Parmar & Perlmann, T., 2017 Jan 5, In : Cell Stem Cell. 20, 1, p. 29-40 12 p.

    Research output: Contribution to journalArticle

  31. TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells

    Per Ludvik Brattås, Marie E. Jönsson, Fasching, L., Jenny Nelander Wahlestedt, Shahsavani, M., Falk, R., Falk, A. H., Jern, P., Malin Parmar & Johan Jakobsson, 2017 Jan 3, In : Cell Reports. 18, 1, p. 1-11 11 p.

    Research output: Contribution to journalArticle

  32. Preface

    Dunnett, S. & A. Björklund, 2017 Jan 1, Functional Neural Transplantation IV Translation to Clinical Application, Part A. Vol. 230. p. xxv-xxvii (Progress in Brain Research).

    Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

  33. Cell reprogramming as a way to produce new functional neurons

    Pereira, M., 2017, Lund: Lund University, Faculty of Medicine. 148 p.

    Research output: ThesisDoctoral Thesis (compilation)

  34. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming

    Ruetz, T., Pfisterer, U., Di Stefano, B., Ashmore, J., Beniazza, M., Tian, T. V., Kaemena, D. F., Tosti, L., Tan, W., Manning, J. R., Chantzoura, E., Daniella Rylander Ottosson, Collombet, S., Johnsson, A., Cohen, E., Yusa, K., Linnarsson, S., Graf, T., Malin Parmar & Kaji, K., 2017, In : Cell Stem Cell. p. 791–805.e9

    Research output: Contribution to journalArticle

  35. IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells

    Lehnen, D., Barral, S., Tiago Cardoso, Shane Grealish, Andreas Heuer, Smiyakin, A., Agnete Kirkeby, Kollet, J., Cremer, H., Malin Parmar, Bosio, A. & Knöbel, S., 2017, In : Stem Cell Reports. 9, 4, p. 1207-1220

    Research output: Contribution to journalArticle

  36. REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways

    Drouin-Ouellet, J., Lau, S., Per Ludvik Brattås, Daniella Ottosson, Karolina Pircs, Daniela A Grassi, Collins, L. M., Vuono, R., Andersson Sjöland, A., Gunilla Westergren-Thorsson, Graff, C., Lennart Minthon, Håkan Toresson, Barker, R. A., Johan Jakobsson & Malin Parmar, 2017, In : EMBO Molecular Medicine. 9, 8, p. 1117-1131

    Research output: Contribution to journalArticle

  37. Strategies for bringing stem cell-derived dopamine neurons to the clinic: A European approach (STEM-PD)

    A. Kirkeby, M. Parmar & Barker, R. A., 2017, Functional Neural Transplantation IV Translation to Clinical Application, Part A. Dunnett, S. B. & Björklund, A. (eds.). Vol. 230. p. 165-190 (Progress in Brain Research; vol. 230).

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  38. 2016
  39. Small molecules increase direct neural conversion of human fibroblasts

    Pfisterer, U., Fredrik Ek, Lang, S., Shamit Soneji, Roger Olsson & Malin Parmar, 2016 Dec 5, In : Scientific Reports. 6, 38290.

    Research output: Contribution to journalArticle

  40. Plug and Play Brain: Understanding Integration of Transplanted Neurons for Brain Repair

    Shane Grealish & Malin Parmar, 2016 Dec 1, In : Cell Stem Cell. 19, 6, p. 679-680 2 p.

    Research output: Contribution to journalArticle

  41. Statins are underused in recent-onset Parkinson's disease with increased vascular risk: findings from the UK Tracking Parkinson's and Oxford Parkinson's Disease Centre (OPDC) discovery cohorts

    Swallow, D. M. A., Lawton, M. A., Grosset, K. A., Malek, N., Klein, J., Baig, F., Ruffmann, C., Bajaj, N. P., Barker, R. A., Ben-Shlomo, Y., Burn, D. J., Foltynie, T., Morris, H. R., Williams, N., Wood, N. W., Hu, M. T. M. & Grosset, D. G., 2016 Nov, In : Journal of Neurology, Neurosurgery and Psychiatry. 87, 11, p. 1183-1190 8 p.

    Research output: Contribution to journalArticle

  42. Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy

    Rittman, T., Rubinov, M., Vértes, P. E., Patel, A. X., Ginestet, C. E., Ghosh, B. C. P., Barker, R. A., Spillantini, M. G., Bullmore, E. T. & Rowe, J. B., 2016 Sep 9, In : Neurobiology of Aging. 48, p. 153-160 8 p.

    Research output: Contribution to journalArticle

  43. The putative tumor suppressor gene EphA7 is a novel BMI-1 target

    Prost, G., Sebastian Braun, Hertwig, F., Winkler, M., Jagemann, L., Sara Nolbrant, Leefa, I. V., Offen, N., Kenichi Miharada, Lang, S., Isabella Artner & Nuber, U. A., 2016 Sep 6, In : Oncotarget. 7, 36, p. 58203-58217 15 p.

    Research output: Contribution to journalArticle

  44. Brain repair and reprogramming: the route to clinical translation

    S. Grealish, Drouin-Ouellet, J. & M. Parmar, 2016 Sep 1, In : Journal of Internal Medicine. 280, 3, p. 265-275 11 p.

    Research output: Contribution to journalReview article

  45. Comparability: Manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015

    Williams, D. J., Archer, R., Archibald, P., Bantounas, I., Baptista, R., Barker, R., Barry, J., Bietrix, F., Blair, N., Braybrook, J., Campbell, J., Canham, M., Chandra, A., Foldes, G., Gilmanshin, R., Girard, M., Gorjup, E., Hewitt, Z., Hourd, P., Hyllner, J. & 29 othersJesson, H., Kee, J., Kerby, J., Kotsopoulou, N., Kowalski, S., Leidel, C., Marshall, D., Masi, L., McCall, M., McCann, C., Medcalf, N., Moore, H., Ozawa, H., Pan, D., Malin Parmar, Plant, A. L., Reinwald, Y., Sebastian, S., Stacey, G., Thomas, R. J., Thomas, D., Thurman-Newell, J., Turner, M., Vitillio, L., Wall, I., Wilson, A., Wolfrum, J., Yang, Y. & Zimmerman, H., 2016 Jul 1, In : Regenerative Medicine. 11, 5, p. 483-492 10 p.

    Research output: Contribution to journalArticle

  46. Serum immune markers and disease progression in an incident Parkinson's disease cohort (ICICLE-PD)

    Williams-Gray, C. H., Wijeyekoon, R., Yarnall, A. J., Lawson, R. A., Breen, D. P., Evans, J. R., Cummins, G. A., Duncan, G. W., Khoo, T. K., Burn, D. J., Barker, R. A. & ICICLE-PD Study Group, 2016 Jul, In : Movement Disorders. 31, 7, p. 995-1003 9 p.

    Research output: Contribution to journalArticle

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