Organisational unit: Research group
Research areas and keywords
UKÄ subject classification
- Immunology in the medical area
- Hematopoiesis, immunology, B cell, lymphocyte, fetal liver, stem cell, barcoding, Lin28
Our team focuses on advancing the conceptual understanding for how the formation of the adaptive immune system changes with developmental timing, and in particular changes in hematopoietic stem cell (HSC) biology and its impact on B cell development and function (Yuan et al, Science, 2012; Kristiansen et al, Immunity, 2016). Using cellular barcoding , VDJ sequencing, and single cell gene expression analysis, we interrogate the ability of stem cell states to impact on downstream fate decisions and immunological diversity. Ongoing projects include: Interrogating the reversibility of adult HSCs to fetal-like plasticity and regenerative potential. Elucidating the basis for the developmental switch in B lineage output early in life. Stratification of the immune system based on developmental timing to visualize the division of labor between fetal and adult hematopoietic stem and progenitor cells.
Recent research outputs
Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon agingPetter Säwen, Mohamed Eldeeb, Eva Erlandsson, Trine A. Kristiansen, Laterza, C., Zaal Kokaia, Göran Karlsson, Joan Yuan, Shamit Soneji, Mandal, P. K., Rossi, D. J. & David Bryder, 2018 Dec 18, In : eLife. 7, e41258.
Research output: Contribution to journal › Article
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