Developmental lymphopoiesis and leukemia

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Acute Lymphoblastic Leukemia, ALL, lymphopoiesis, target cell, pre-leukemic clone, B-cell, B-ALL

Description

Research

Acute Lymphoblastic Leukemia (ALL) is one of the most common cancers in children. While this type of malignancy is found in both children and adults, childhood (c) B-ALL differs from the disease in adults with higher incidence, better prognosis but also a specific mutational spectrum. These facts suggest differences in the underlying biology and in the initiation of the disease between adults and children. Many of the initiating mutations in cALL have been shown to occur already during fetal life. The targeted cells form a pre-leukemic clone, pre-disposed to develop leukemia when encountering additional mutations. How the leukemia process initiates is poorly understood and cALL offers a unique possibility to study this since many of the initiating mutations are known. The main focus of the lab is to understand how the leukemia starts: the origin of the pre-leukemic clone and the molecular pathways which regulate the initiation of the disease.

Recent research outputs

Charlotta Böiers, Simon E. Richardson, Emma Laycock, Alya Zriwil, Virginia A. Turati, John Brown, Jason P. Wray, Dapeng Wang, Chela James, Javier Herrero, Ewa Sitnicka, Stefan Karlsson, Andrew J.H. Smith, Sten Erik W. Jacobsen & Tariq Enver, 2018 Feb 5, In: Developmental Cell. 44, 3, p. 362-377.e7

Research output: Contribution to journalArticle

Alya Zriwil, Charlotta Böiers, Trine A. Kristiansen, Lilian Wittmann, Joan Yuan, Claus Nerlov, Ewa Sitnicka & Sten E.W. Jacobsen, 2018, In: British Journal of Haematology. 183, 4, p. 588-600 13 p.

Research output: Contribution to journalArticle

Göran Karlsson, Mikael Sigvardsson & Charlotta Böiers, 2017 Dec 15, In: EMBO Journal. 36, 24, p. 3552-3554 3 p.

Research output: Contribution to journalArticle

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