Diabetes - Cardiovascular Disease

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Nutrition and Dietetics
  • Medical Genetics

Keywords

  • Obesity, genome, epidemiology

Description

We challenge the question of how environmental (diet, physical activity, alcohol) factors modify genetic associations put forward by us and others, in recent genome wide association studies (GWAS) of lipoprotein traits, cardiovascular disease (CVD) and obesity and aim to utilize this information in intervention studies and in development of prediction models. We work to further improve genetic CVD / obesity risk prediction by extending our previous genetic risk scores with the exploding knowledge on CVD and obesity genetics currently evolving. Importantly, by combining expertise in multifactorial genetics/ genetic epidemiology / molecular biology with nutrition epidemiology and systems biology, we take steps further challenging the question of interactions between the genetic and environmental risk factors of these traits in very large epidemiological cohorts with long follow-up times and world-unique dietary data available (Malmö Diet and Cancer Study).

Recent research outputs

Jiangming Sun, Yunpeng Wang, Lasse Folkersen, Yan Borné, Inge Amlien, Alfonso Buil, Marju Orho-Melander, Anders D Børglum, David M Hougaard, Regeneron Genetics Center Regeneron Genetics Center, Olle Melander, Gunnar Engström, Thomas Werge & Kasper Lage, 2021 Sep 6, In: Nature Communications. 12, p. 5276

Research output: Contribution to journalArticle

Reynalda Cordova, Nathalie Kliemann, Inge Huybrechts, Fernanda Rauber, Eszter P Vamos, Renata Bertazzi Levy, Karl-Heinz Wagner, Vivian Viallon, Corinne Casagrande, Geneviève Nicolas, Christina C Dahm, Jie Zhang, Jytte Halkjær, Anne Tjønneland, Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Nasser Laouali, Verena Katzke, Bernard Srour, Franziska Jannasch & 23 others, Matthias B Schulze, Giovanna Masala, Sara Grioni, Salvatore Panico, Yvonne T van der Schouw, Jeroen W G Derksen, Charlotta Rylander, Guri Skeie, Paula Jakszyn, Miguel Rodriguez-Barranco, José María Huerta, Aurelio Barricarte, Lousie Brunkwall, Stina Ramne, Stina Bodén, Aurora Perez-Cornago, Alicia K Heath, Paolo Vineis, Elisabete Weiderpass, Carlos Augusto Monteiro, Marc J Gunter, Christopher Millett & Heinz Freisling, 2021 Aug 21, In: Clinical Nutrition. 40, 9, p. 5079-5088

Research output: Contribution to journalArticle

Elom K. Aglago, Neil Murphy, Inge Huybrechts, Geneviève Nicolas, Corinne Casagrande, Veronika Fedirko, Elisabete Weiderpass, Joseph A. Rothwell, Christina C. Dahm, Anja Olsen, Anne Tjønneland, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Giovanna Masala, Claudia Agnoli, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Bas H. Bueno-de-Mesquita & 15 others, Jeroen W.G. Derksen, Guri Skeie, Inger Torhild Gram, Magritt Brustad, Paula Jakszyn, Maria Jose Sánchez, Pilar Amiano, José María Huerta, Ulrika Ericson, Maria Wennberg, Aurora Perez-Cornago, Alicia K. Heath, Mazda Jenab, Veronique Chajes & Marc J. Gunter, 2021 Aug 15, In: International Journal of Cancer. 149, 4, p. 865-882 18 p.

Research output: Contribution to journalArticle

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