Diabetes - Cardiovascular Disease

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Nutrition and Dietetics
  • Medical Genetics

Keywords

  • Obesity, genome, epidemiology

Description

We challenge the question of how environmental (diet, physical activity, alcohol) factors modify genetic associations put forward by us and others, in recent genome wide association studies (GWAS) of lipoprotein traits, cardiovascular disease (CVD) and obesity and aim to utilize this information in intervention studies and in development of prediction models. We work to further improve genetic CVD / obesity risk prediction by extending our previous genetic risk scores with the exploding knowledge on CVD and obesity genetics currently evolving. Importantly, by combining expertise in multifactorial genetics/ genetic epidemiology / molecular biology with nutrition epidemiology and systems biology, we take steps further challenging the question of interactions between the genetic and environmental risk factors of these traits in very large epidemiological cohorts with long follow-up times and world-unique dietary data available (Malmö Diet and Cancer Study).

Recent research outputs

Shungin, D., Haworth, S., Divaris, K., Agler, C. S., Kamatani, Y., Keun Lee, M., Grinde, K., Hindy, G., Alaraudanjoki, V., Pesonen, P., Teumer, A., Holtfreter, B., Sakaue, S., Hirata, J., Yu, Y. H., Ridker, P. M., Giulianini, F., Chasman, D. I., Magnusson, P. K. E., Sudo, T. & 18 othersOkada, Y., Völker, U., Kocher, T., Anttonen, V., Laitala, M. L., Marju Orho-Melander, Sofer, T., Shaffer, J. R., Vieira, A., Marazita, M. L., Kubo, M., Furuichi, Y., North, K. E., Offenbacher, S., Ingelsson, E., Paul W. Franks, Timpson, N. J. & Johansson, I., 2019 Jun 24, In : Nature Communications. 10, 1, 2773.

Research output: Contribution to journalArticle

Sofia Enhörning, Louise Brunkwall, Irina Tasevska, Ulrika Ericson, Persson Tholin, J., Margaretha Persson, Lemetais, G., Vanhaecke, T., Dolci, A., Perrier, E. T. & Olle Melander, 2019 Jun 1, In : The Journal of clinical endocrinology and metabolism. 104, 6, p. 1917-1925 9 p.

Research output: Contribution to journalArticle

Lifelines Cohort Study & Pattaro, C., 2019 May 31, In : Nature Genetics. 51, 6, p. 957-972 16 p.

Research output: Contribution to journalArticle

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