Diabetes - Clinical Obesity

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Nutrition and Dietetics

Keywords

  • Obesity, diabesity, Type 2 diabetes

Description

The prevalence of obesity and type 2 diabetes (T2DM) is increasing worldwide. Although our therapeutic arsenal to beget these conditions and their consequences in the form of cardiovascular morbidity and mortality is increasing a lot still needs to be learned about the underlying mechanisms. Our research deals with clinical care and therapy of obesity and T2DM, collectively called "diabesity", as well as probing of underlying genetic mechanisms. We study variation in separate candidate genes such as PPAR-gamma, PGC1-alpha, CAPN10, FOXC2, APM1, ADPN, TCF7L2 and FTO, the transcription of these genes in skeletal muscle and adipose tissue biopsies or cells as well as changes in the whole transcriptome by cDNA-microarray. Our patient materials include both grown-ups and children.

Recent research outputs

Nina Geidenstam, Yu Han H. Hsu, Christina M. Astley, Josep M. Mercader, Martin Ridderstråle, Maria E. Gonzalez, Clicerio Gonzalez, Joel N. Hirschhorn & Rany M. Salem, 2019, In: PLoS ONE. 14, 9, e0222445.

Research output: Contribution to journalArticle

Narges Safai, Bendix Carstensen, Henrik Vestergaard & Martin Ridderstråle, 2018 Mar 1, In: BMJ Open. 8, 3, e019214.

Research output: Contribution to journalArticle

Anders Frid, Andrea Tura, Giovanni Pacini & Martin Ridderstråle, 2017 Sep 12, In: Nutrients. 9, 9, 1004.

Research output: Contribution to journalArticle

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