Diabetes - Epigenetics

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Medical Genetics
  • Cell and Molecular Biology


  • Epigenetics, DNA, Type 2 diabetes


Type 2 diabetes develops as a conspiracy between the genetic background and the environment. The interaction between genes and environment may involve epigenetic factors, such as DNA methylation and histone modifications, to promote type 2 diabetes. The overall objective of our research is to identify the key epigenetic mechanisms influencing the pathogenesis of T2D. We are currently analysing DNA methylation and histone modifications in a number of human cohorts. Here, we examine if non-genetic and genetic factors as well as type 2 diabetes affect epigenetic variation in human tissues. We are further relating DNA methylation to gene expression, in vivo metabolism and type 2 diabetes. Furthermore, we are dissecting the role of epigenetic enzymes in development of type 2 diabetes.

Recent research outputs

Broholm, C., Ribel-Madsen, R., Line Hjort, Olsson, A. H., Ahlers, J. M. D., Hansen, N. S., Schrölkamp, M., Gillberg, L., Alexander Perfilyev, Volkov, P., Charlotte Ling, Jørgensen, S. W., Mortensen, B., Hingst, J., Wojtaszewski, J., Scheele, C., Brøns, C., Pedersen, B. K. & Allan Vaag, 2020, In : Endocrine Research. 45, 1, p. 58-71 14 p.

Research output: Contribution to journalArticle

Huang, T. T., Ruben Smith, Karl Bacos, Song, D. Y., Faull, R. M., Waldvogel, H. J. & Jia Yi Li, 2020, In : Acta neuropathologica communications. 8, 1, 77.

Research output: Contribution to journalArticle

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