Diabetes - Epigenetics

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Medical Genetics
  • Cell and Molecular Biology

Keywords

  • Epigenetics, DNA, Type 2 diabetes

Description

Type 2 diabetes develops as a conspiracy between the genetic background and the environment. The interaction between genes and environment may involve epigenetic factors, such as DNA methylation and histone modifications, to promote type 2 diabetes. The overall objective of our research is to identify the key epigenetic mechanisms influencing the pathogenesis of T2D. We are currently analysing DNA methylation and histone modifications in a number of human cohorts. Here, we examine if non-genetic and genetic factors as well as type 2 diabetes affect epigenetic variation in human tissues. We are further relating DNA methylation to gene expression, in vivo metabolism and type 2 diabetes. Furthermore, we are dissecting the role of epigenetic enzymes in development of type 2 diabetes.

Recent research outputs

Cajsa Davegårdh, Johanna Säll, Anna Benrick, Christa Broholm, Petr Volkov, Alexander Perfilyev, Tora Ida Henriksen, Yanling Wu, Line Hjort, Charlotte Brøns, Ola Hansson, Maria Pedersen, Jens U Würthner, Klaus Pfeffer, Emma Nilsson, Allan Vaag, Elisabet Stener-Victorin, Karolina Pircs, Camilla Scheele & Charlotte Ling, 2021 Apr 23, In: Nature Communications. 12, 2431.

Research output: Contribution to journalArticle

Josefine Jönsson, Kristina M. Renault, Sonia García-Calzón, Alexander Perfilyev, Angela C. Estampador, Kirsten Nørgaard, Mads Vendelbo Lind, Allan Vaag, Line Hjort, Kim F. Michaelsen, Emma Malchau Carlsen, Paul W. Franks & Charlotte Ling, 2021, In: Diabetes. 70, 4, p. 854-866 13 p.

Research output: Contribution to journalArticle

Vanessa D. de Mello, Ratika Sehgal, Ville Männistö, Anton Klåvus, Emma A Nilsson, Alexander Perfilyev, Dorota Kaminska, Zong Miao, Päivi Pajukanta, Charlotte Ling, Kati Hanhineva & Jussi Pihlajamäki, 2021, In: Liver International. 41, 4, p. 754-763

Research output: Contribution to journalArticle

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