Diabetes - Epigenetics

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Medical Genetics
  • Cell and Molecular Biology

Keywords

  • Epigenetics, DNA, Type 2 diabetes

Description

Type 2 diabetes develops as a conspiracy between the genetic background and the environment. The interaction between genes and environment may involve epigenetic factors, such as DNA methylation and histone modifications, to promote type 2 diabetes. The overall objective of our research is to identify the key epigenetic mechanisms influencing the pathogenesis of T2D. We are currently analysing DNA methylation and histone modifications in a number of human cohorts. Here, we examine if non-genetic and genetic factors as well as type 2 diabetes affect epigenetic variation in human tissues. We are further relating DNA methylation to gene expression, in vivo metabolism and type 2 diabetes. Furthermore, we are dissecting the role of epigenetic enzymes in development of type 2 diabetes.

Recent research outputs

Bysani, M., Agren, R., Cajsa Davegårdh, Petr Volkov, Tina Rönn, Unneberg, P., Karl Bacos & Charlotte Ling, 2019 May 23, In : Scientific Reports. 7785 .

Research output: Contribution to journalArticle

Walle, P., Männistö, V., De Mello, V. D., Vaittinen, M., Alexander Perfilyev, Hanhineva, K., Charlotte Ling & Pihlajamäki, J., 2019 Jan 17, In : Clinical Epigenetics. 11, 1, 10.

Research output: Contribution to journalArticle

Cajsa Davegårdh, Hall Wedin, E., Broholm, C., Henriksen, T. I., Pedersen, M., Pedersen, B. K., Scheele, C. & Charlotte Ling, 2019 Jan 15, In : Stem Cell Research and Therapy. 10, 1, 26.

Research output: Contribution to journalArticle

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