Diabetes - Epigenetics

Organisational unit: Research group

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  1. 2020
  2. Epigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men

    Broholm, C., Ribel-Madsen, R., Line Hjort, Olsson, A. H., Ahlers, J. M. D., Hansen, N. S., Schrölkamp, M., Gillberg, L., Alexander Perfilyev, Volkov, P., Charlotte Ling, Jørgensen, S. W., Mortensen, B., Hingst, J., Wojtaszewski, J., Scheele, C., Brøns, C., Pedersen, B. K. & Allan Vaag, 2020, In : Endocrine Research. 45, 1, p. 58-71 14 p.

    Research output: Contribution to journalArticle

  3. No symphony without bassoon and piccolo: Changes in synaptic active zone proteins in Huntington's disease

    Huang, T. T., Ruben Smith, Karl Bacos, Song, D. Y., Faull, R. M., Waldvogel, H. J. & Jia Yi Li, 2020, In : Acta neuropathologica communications. 8, 1, 77.

    Research output: Contribution to journalArticle

  4. 2019
  5. Low-Dose Oral Ketamine for Procedural Analgesia in Pediatric Cancer Patients Undergoing Lumbar Puncture at a Resource-Limited Cancer Hospital in India

    Rayala, S., Bäckdahl, T., Reddy, N., Jacob, J., Gebre-Medhin, E., Karonen, E., Palat, G., Sinha, S., Schyman, T., Thomas Wiebe, Eva Brun & Mikael Segerlantz, 2019 Oct 25, In : Journal of Palliative Medicine. 22, 11, p. 1357-1363

    Research output: Contribution to journalArticle

  6. Glucolipotoxicity alters insulin secretion via epigenetic changes in human islets

    Hall, E., Josefine Jönsson, Jones K. Ofori, Volkov, P., Alexander Perfilyev, Nitert, M. D., Lena Eliasson, Charlotte Ling & Karl Bacos, 2019 Oct, In : Diabetes. 68, 10, p. 1965-1974

    Research output: Contribution to journalArticle

  7. ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes.

    Bysani, M., Agren, R., Cajsa Davegårdh, Volkov, P., Tina Rönn, Unneberg, P., Karl Bacos & Charlotte Ling, 2019 May 23, In : Scientific Reports. 9, 7785 .

    Research output: Contribution to journalArticle

  8. Liver DNA methylation of FADS2 associates with FADS2 genotypex 06 Biological Sciences 0604 Genetics

    Walle, P., Männistö, V., De Mello, V. D., Vaittinen, M., Alexander Perfilyev, Hanhineva, K., Charlotte Ling & Pihlajamäki, J., 2019 Jan 17, In : Clinical Epigenetics. 11, 1, 10.

    Research output: Contribution to journalArticle

  9. Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes

    Cajsa Davegårdh, Hall Wedin, E., Broholm, C., Henriksen, T. I., Pedersen, M., Pedersen, B. K., Scheele, C. & Charlotte Ling, 2019 Jan 15, In : Stem Cell Research and Therapy. 10, 1, 26.

    Research output: Contribution to journalArticle

  10. Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

    Kluth, O., Stadion, M., Gottmann, P., Aga, H., Jähnert, M., Scherneck, S., Vogel, H., Krus, U., Seelig, A., Charlotte Ling, Gerdes, J. & Schürmann, A., 2019, In : Cell Reports. 26, 11, p. 3027-3036.e3

    Research output: Contribution to journalArticle

  11. Epigenetics in Human Obesity and Type 2 Diabetes

    Charlotte Ling & Tina Rönn, 2019, In : Cell Metabolism. 29, 5, p. 1028-1044 17 p.

    Research output: Contribution to journalReview article

  12. Epigenome-wide association study of incident type 2 diabetes in a British population: EPIC-Norfolk study

    Cardona, A., Day, F. R., Perry, J. R. B., Loh, M., Chu, A. Y., Lehne, B., Paul, D. S., Lotta, L. A., Stewart, I. D., Kerrison, N. D., Scott, R. A., Khaw, K. T., Forouhi, N. G., Langenberg, C., Liu, C., Mendelson, M. M., Levy, D., Beck, S., Leslie, R. D., Dupuis, J. & 10 others, Meigs, J. B., Kooner, J. S., Pihlajamäki, J., Allan Vaag, Alexander Perfilyev, Charlotte Ling, Hivert, M. F., Chambers, J. C., Wareham, N. J. & Ong, K. K., 2019, In : Diabetes. 68, 12, p. 2315-2326 12 p.

    Research output: Contribution to journalArticle

  13. Insulin induces Thr484 phosphorylation and stabilization of SIK2 in adipocytes

    Johanna Säll, Florentina Negoita, Hansson, B., Franziska Kopietz, Linder, W., Pettersson, A. M. L., Mikael Ekelund, Laurencikiene, J., Eva Degerman, Karin G Stenkula & Olga Göransson, 2019, In : Cellular Signalling. 55, p. 73-80

    Research output: Contribution to journalArticle

  14. The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

    Backe, M. B., Jin, C., Andreone, L., Sankar, A., Agger, K., Helin, K., Madsen, A. N., Poulsen, S. S., Bysani, M., Karl Bacos, Charlotte Ling, Perone, M. J., Holst, B. & Mandrup-Poulsen, T., 2019, In : Journal of Diabetes Research. 2019, 5451038.

    Research output: Contribution to journalArticle

  15. 2018
  16. A Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary Syndrome

    Kokosar, M., Benrick, A., Alexander Perfilyev, Emma Nilsson, Källman, T., Ohlsson, C., Charlotte Ling & Stener-Victorin, E., 2018 Dec 1, In : Scientific Reports. 8, 1, 1878.

    Research output: Contribution to journalArticle

  17. Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children

    Line Hjort, Martino, D., Grunnet, L. G., Naeem, H., Maksimovic, J., Olsson, A. H., Zhang, C., Charlotte Ling, Olsen, S. F., Saffery, R. & Allan Arthur Vaag, 2018 Sep 6, In : JCI Insight. 3, 17, e122572.

    Research output: Contribution to journalArticle

  18. Serum and gene expression levels of CT-1, IL-6, and TNF-α after a lifestyle intervention in obese children

    Marti, A., Morell-Azanza, L., Rendo-Urteaga, T., S. García-Calzón, Ojeda-Rodríguez, A., Martín-Calvo, N., Moreno-Aliaga, M. J., Martínez, J. A. & Azcona-San Julián, M. C., 2018 Mar, In : Pediatric Diabetes. 19, 2, p. 217-222 6 p.

    Research output: Contribution to journalArticle

  19. DNA methylation patterns in human adipose tissue in relation to diet and type 2 diabetes

    Alexander Perfilyev, 2018, Lund: Lund University: Faculty of Medicine. 47 p.

    Research output: ThesisDoctoral Thesis (compilation)

  20. Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

    Backe, M. B., Andersson, J. L., Karl Bacos, Christensen, D. P., Hansen, J. B., Dorosz, J. J., Gajhede, M., Dahlby, T., Bysani, M., Kristensen, L. H., Charlotte Ling, Olsen, L. & Mandrup-Poulsen, T., 2018, In : Molecular and Cellular Endocrinology. 460, p. 47-56

    Research output: Contribution to journalArticle

  21. The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets

    Hall, E., Dekker Nitert, M., Volkov, P., Malmgren, S., Hindrik Mulder, Karl Bacos & Charlotte Ling, 2018, In : Molecular and Cellular Endocrinology. 472, p. 57-67

    Research output: Contribution to journalArticle

  22. 2017
  23. Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

    Sonia García-Calzón, Alexander Perfilyev, Männistö, V., de Mello, V., Emma A Nilsson, Pihlajamäki, J. & Charlotte Ling, 2017 Sep 21, In : Clinical Epigenetics. 9, 1, p. 1-9 102.

    Research output: Contribution to journalArticle

  24. 36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner

    Hjort, L., Jørgensen, S. W., Gillberg, L., Hall, E., Brøns, C., Frystyk, J., Allan A. Vaag & Charlotte Ling, 2017 Apr 21, In : Clinical Epigenetics. 9, 1, 40.

    Research output: Contribution to journalArticle

  25. Fetal hyperglycemia changes human preadipocyte function in adult life

    Hansen, N. S., Strasko, K. S., Hjort, L., Kelstrup, L., Houshmand-ØRegaard, A., Schrölkamp, M., Schultz, H. S., Scheele, C., Pedersen, B. K., Charlotte Ling, Clausen, T. D., Damm, P., Allan Vaag & Broholm, C., 2017 Apr 1, In : Journal of Clinical Endocrinology and Metabolism. 102, 4, p. 1141-1150 10 p.

    Research output: Contribution to journalArticle

  26. Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: A randomized controlled trial

    Alexander Perfilyev, Dahlman, I., Gillberg, L., Rosqvist, F., Iggman, D., Volkov, P., Emma Nilsson, Risérus, U. & Charlotte Ling, 2017 Apr 1, In : American Journal of Clinical Nutrition. 105, 4, p. 991-1000 10 p.

    Research output: Contribution to journalArticle

  27. Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver

    Bysani, M., Alexander Perfilyev, de Mello, V., Tina Rönn, Nilsson, E., Pihlajamäki, J. & Charlotte Ling, 2017 Feb 1, In : Epigenomics. 9, 2, p. 105-122 18 p.

    Research output: Contribution to journalArticle

  28. Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity

    Keller, M., Hopp, L., Liu, X., Wohland, T., Rohde, K., Cancello, R., Klös, M., Bacos, K., Kern, M., Eichelmann, F., Dietrich, A., Schön, M. R., Gärtner, D., Lohmann, T., Dreßler, M., Stumvoll, M., Kovacs, P., DiBlasio, A. M., Ling, C., Binder, H. & 2 others, Blüher, M. & Böttcher, Y., 2017 Jan 1, In : Molecular Metabolism. 6, 1, p. 86-100 15 p.

    Research output: Contribution to journalArticle

  29. Hepatic DPP4 DNA methylation associates with fatty liver

    Baumeier, C., Saussenthaler, S., Kammel, A., Jähnert, M., Schlüter, L., Hesse, D., Canouil, M., Lobbens, S., Caiazzo, R., Raverdy, V., Pattou, F., Nilsson, E., Pihlajamäki, J., Charlotte Ling, Froguel, P., Schürmann, A. & Schwenk, R. W., 2017 Jan 1, In : Diabetes. 66, 1, p. 25-35 11 p.

    Research output: Contribution to journalArticle

  30. HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

    Daneshpajooh, M., Karl Bacos, Bysani, M., Bagge, A., Ottosson Laakso, E., Petter Vikman, Lena Eliasson, Hindrik Mulder & Charlotte Ling, 2017 Jan, In : Diabetologia. 60, 1, p. 116–125

    Research output: Contribution to journalArticle

  31. Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action

    de Mello, V., Matte, A., Alexander Perfilyev, Männistö, V., Tina Rönn, Nilsson, E., Käkelä, P., Charlotte Ling & Pihlajamäki, J., 2017, In : Epigenetics. 12, 4, p. 287-295 9 p.

    Research output: Contribution to journalArticle

  32. Role of dietary pattern and obesity on telomere homeostasis

    Sonia García-Calzón & Del Moral, A. M., 2017, Telomeres, Diet and Human Disease: Advances and Therapeutic Opportunities. CRC Press, p. 133-148

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  33. Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents

    Morell-Azanza, L., Sonia García-Calzón, Rendo-Urteaga, T., Martin-Calvo, N., Chueca, M., Martínez, J. A., Azcona-Sanjulián, M. C. & Marti, A., 2017, In : Pediatric Diabetes. 18, 5, p. 392-398

    Research output: Contribution to journalArticle

  34. 2016
  35. Human adipogenesis is associated with genome-wide DNA methylation and gene-expression changes

    Broholm, C., Olsson, A. H., Alexander Perfilyev, Gillberg, L., Hansen, N. S., Ashfaq Ali, Mortensen, B., Charlotte Ling & Allan Vaag, 2016 Dec 1, In : Epigenomics. 8, 12, p. 1601-1617 17 p.

    Research output: Contribution to journalArticle

  36. Epigenetic programming of adipose-derived stem cells in low birthweight individuals

    Broholm, C., Olsson, A. H., Alexander Perfilyev, Hansen, N. S., Schrölkamp, M., Strasko, K. S., Scheele, C., Ribel-Madsen, R., Mortensen, B., Jørgensen, S. W., Charlotte Ling & Vaag, A., 2016 Dec, In : Diabetologia. 59, 12, p. 2664–2673 10 p.

    Research output: Contribution to journalArticle

  37. Epigenetic markers to further understand insulin resistance

    Charlotte Ling & Tina Rönn, 2016 Nov 1, In : Diabetologia. 59, 11, p. 2295-2297

    Research output: Contribution to journalDebate/Note/Editorial

  38. DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk

    Dayeh, T., Tuomi, T., Almgren, P., Alexander Perfilyev, Jansson, P. A., de Mello, V. D., Pihlajamäki, J., Allan Vaag, Leif Groop, Nilsson, E. & Charlotte Ling, 2016 Jul 2, In : Epigenetics. 11, 7, p. 482-488 7 p.

    Research output: Contribution to journalArticle

  39. A genome-wide mQTL analysis in human adipose tissue identifies genetic variants associated with DNA methylation, gene expression and metabolic traits

    Volkov, P., Olsson, A. H., Gillberg, L., Jørgensen, S. W., Brøns, C., Karl Fredrik Eriksson, Leif Groop, Jansson, P. A., Nilsson, E., Tina Rönn, Allan Vaag & Charlotte Ling, 2016 Jun 1, In : PLoS ONE. 11, 6, e0157776.

    Research output: Contribution to journalArticle

  40. A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

    Peiris, H., Duffield, M. D., Fadista, J., Jessup, C. F., Kashmir, V., Genders, A. J., McGee, S. L., Martin, A. M., Saiedi, M., Morton, N., Carter, R., Cousin, M. A., Kokotos, A. C., Oskolkov, N., Volkov, P., Hough, T. A., Fisher, E. M. C., Tybulewicz, V. L. J., Busciglio, J., Coskun, P. E. & 12 others, Becker, A., Belichenko, P. V., Mobley, W. C., Ryan, M. T., Chan, J. Y., Laybutt, D. R., Coates, P. T., Yang, S., Charlotte Ling, Leif Groop, Pritchard, M. A. & Keating, D. J., 2016 May 1, In : PLoS Genetics. 12, 5, e1006033.

    Research output: Contribution to journalArticle

  41. Developmental programming: State-of-the-science and future directions: Summary from a Pennington Biomedical symposium

    Sutton, E. F., Gilmore, L. A., Dunger, D. B., Heijmans, B. T., Hivert, M-F., Charlotte Ling, Martinez, J. A., Ozanne, S. E., Simmons, R. A., Szyf, M., Waterland, R. A., Redman, L. M. & Ravussin, E., 2016 May, In : Obesity. 24, 5, p. 1018–1026

    Research output: Contribution to journalReview article

  42. Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.

    Gillberg, L., Alexander Perfilyev, Brøns, C., Thomasen, M., Grunnet, L. G., Volkov, P., Rosqvist, F., Iggman, D., Dahlman, I., Risérus, U., Tina Rönn, Emma A Nilsson, Vaag, A. & Charlotte Ling, 2016, In : Diabetologia. 59, 4, p. 799-812

    Research output: Contribution to journalArticle

  43. Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

    Karl Bacos, Gillberg, L., Volkov, P., Olsson, A. H., Hansen, T., Pedersen, O., Gjesing, A. P., Eiberg, H., Tuomi, T., Almgren, P., Leif Groop, Lena Eliasson, Allan Vaag, Dayeh, T. & Charlotte Ling, 2016, In : Nature Communications. 7, 11089.

    Research output: Contribution to journalArticle

  44. Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome

    Kokosar, M., Benrick, A., Alexander Perfilyev, Fornes, R., Emma A Nilsson, Maliqueo, M., Behre, C. J., Sazonova, A., Ohlsson, C., Charlotte Ling & Stener-Victorin, E., 2016, In : Scientific Reports. 6, 22883.

    Research output: Contribution to journalArticle

  45. Genome-wide analysis of the DNA methylation landscape in human tissues

    Volkov, P., 2016, Lund: Lund University: Faculty of Medicine. 66 p.

    Research output: ThesisDoctoral Thesis (compilation)

  46. NIH working group report-using genomic information to guide weight management: From universal to precision treatment.

    Bray, M. S., Loos, R. J. F., McCaffery, J. M., Charlotte Ling, Paul Franks, Weinstock, G. M., Snyder, M. P., Vassy, J. L. & Agurs-Collins, T., 2016, In : Obesity. 24, 1, p. 14-22

    Research output: Contribution to journalReview article

  47. Risk för typ 2-diabetes kunde förutspås med epigenetik

    Karl Bacos & Charlotte Ling, 2016, In : Läkartidningen. 113, 17

    Research output: Contribution to journalArticle

  48. The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes

    Dayeh, T., 2016, Epigenetics and Diabetes. 170 p.

    Research output: ThesisDoctoral Thesis (compilation)

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