Diabetes - Epigenetics

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  1. 2021
  2. Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes

    Silja Schrader, Alexander Perfilyev, Mats Martinell, Sonia García-Calzón & Charlotte Ling, 2021 Jun 1, In: Epigenomics. 13, 12, p. 919-925 7 p.

    Research output: Contribution to journalArticle

  3. VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics

    Cajsa Davegårdh, Johanna Säll, Anna Benrick, Christa Broholm, Petr Volkov, Alexander Perfilyev, Tora Ida Henriksen, Yanling Wu, Line Hjort, Charlotte Brøns, Ola Hansson, Maria Pedersen, Jens U Würthner, Klaus Pfeffer, Emma Nilsson, Allan Vaag, Elisabet Stener-Victorin, Karolina Pircs, Camilla Scheele & Charlotte Ling, 2021 Apr 23, In: Nature Communications. 12, 2431.

    Research output: Contribution to journalArticle

  4. Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring

    Josefine Jönsson, Kristina M. Renault, Sonia García-Calzón, Alexander Perfilyev, Angela C. Estampador, Kirsten Nørgaard, Mads Vendelbo Lind, Allan Vaag, Line Hjort, Kim F. Michaelsen, Emma Malchau Carlsen, Paul W. Franks & Charlotte Ling, 2021, In: Diabetes. 70, 4, p. 854-866 13 p.

    Research output: Contribution to journalArticle

  5. Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids

    Vanessa D. de Mello, Ratika Sehgal, Ville Männistö, Anton Klåvus, Emma A Nilsson, Alexander Perfilyev, Dorota Kaminska, Zong Miao, Päivi Pajukanta, Charlotte Ling, Kati Hanhineva & Jussi Pihlajamäki, 2021, In: Liver International. 41, 4, p. 754-763

    Research output: Contribution to journalArticle

  6. 2020
  7. Epigenetic regulation of insulin action and secretion – role in the pathogenesis of type 2 diabetes

    C. Ling, 2020 Aug, In: Journal of Internal Medicine. 288, 2, p. 158-167 10 p.

    Research output: Contribution to journalReview article

  8. Electroacupuncture mimics exercise-induced changes in skeletal muscle gene expression in women with polycystic ovary syndrome

    Anna Benrick, Nicolas J. Pillon, Emma Nilsson, Eva Lindgren, Anna Krook, Charlotte Ling & Elisabet Stener-Victorin, 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 6, p. 2027–2041

    Research output: Contribution to journalArticle

  9. Epigenetic changes in islets of langerhans preceding the onset of diabetes

    Meriem Ouni, Sophie Saussenthaler, Fabian Eichelmann, Markus Jähnert, Mandy Stadion, Clemens Wittenbecher, Tina Rönn, Lisa Zellner, Pascal Gottmann, Charlotte Ling, Matthias B. Schulze & Annette Schürmann, 2020, In: Diabetes. 69, 11, p. 2503-2517 15 p.

    Research output: Contribution to journalArticle

  10. Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

    Sonia García-Calzón, Alexander Perfilyev, Mats Martinell, Monta Ustinova, Sebastian Kalamajski, Paul W. Franks, Karl Bacos, Ilze Elbere, Jussi Pihlajamäki, Petr Volkov, Allan Vaag, Leif Groop, Marlena Maziarz, Janis Klovins, Emma Ahlqvist & Charlotte Ling, 2020, In: Science Translational Medicine. 12, 561, eaaz1803.

    Research output: Contribution to journalArticle

  11. Epigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men

    Christa Broholm, Rasmus Ribel-Madsen, Line Hjort, Anders Henrik Olsson, Juliane Maria Dorothee Ahlers, Ninna Schiøler Hansen, Maren Schrölkamp, Linn Gillberg, Alexander Perfilyev, Petr Volkov, Charlotte Ling, Sine W. Jørgensen, Brynjulf Mortensen, Janne Hingst, Jørgen Wojtaszewski, Camilla Scheele, Charlotte Brøns, Bente Klarlund Pedersen & Allan Vaag, 2020, In: Endocrine Research. 45, 1, p. 58-71 14 p.

    Research output: Contribution to journalArticle

  12. Mediterranean Diet and Telomere Length: A Systematic Review and Meta-Analysis

    Silvia Canudas, Nerea Becerra-Tomas, Pablo Hernandez-Alonso, Serena Galie, Cindy Leung, Marta Crous-Bou, Immaculata De Vivo, Yawen Gao, Yian Gu, Jelena Meinila, Catherine Milte, Sonia Garcia-Calzon, Amelia Marti, Virginia Boccardi, Melissa Ventura-Marra & Jordi Salas-Salvado, 2020, In: Advances in Nutrition. 11, 6, p. 1544-1554 11 p.

    Research output: Contribution to journalReview article

  13. No symphony without bassoon and piccolo: Changes in synaptic active zone proteins in Huntington's disease

    Ting Ting Huang, Ruben Smith, Karl Bacos, Dong Yan Song, Richard M. Faull, Henry J. Waldvogel & Jia Yi Li, 2020, In: Acta Neuropathologica Communications. 8, 1, 77.

    Research output: Contribution to journalArticle

  14. 2019
  15. Low-Dose Oral Ketamine for Procedural Analgesia in Pediatric Cancer Patients Undergoing Lumbar Puncture at a Resource-Limited Cancer Hospital in India

    Spandana Rayala, Tim Bäckdahl, Naresh Reddy, Jean Jacob, Erik Gebre-Medhin, Emil Karonen, Gayatri Palat, Sudha Sinha, Tommy Schyman, Thomas Wiebe, Eva Brun & Mikael Segerlantz, 2019 Oct 25, In: Journal of Palliative Medicine. 22, 11, p. 1357-1363

    Research output: Contribution to journalArticle

  16. Glucolipotoxicity alters insulin secretion via epigenetic changes in human islets

    Elin Hall, Josefine Jönsson, Jones K. Ofori, Petr Volkov, Alexander Perfilyev, Marloes Dekker Nitert, Lena Eliasson, Charlotte Ling & Karl Bacos, 2019 Oct, In: Diabetes. 68, 10, p. 1965-1974

    Research output: Contribution to journalArticle

  17. ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes.

    Madhusudhan Bysani, Rasmus Agren, Cajsa Davegårdh, Petr Volkov, Tina Rönn, Per Unneberg, Karl Bacos & Charlotte Ling, 2019 May 23, In: Scientific Reports. 9, 7785 .

    Research output: Contribution to journalArticle

  18. Liver DNA methylation of FADS2 associates with FADS2 genotypex 06 Biological Sciences 0604 Genetics

    Paula Walle, Ville Männistö, Vanessa Derenji De Mello, Maija Vaittinen, Alexander Perfilyev, Kati Hanhineva, Charlotte Ling & Jussi Pihlajamäki, 2019 Jan 17, In: Clinical Epigenetics. 11, 1, 10.

    Research output: Contribution to journalArticle

  19. Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes

    Cajsa Davegårdh, Elin Hall Wedin, Christa Broholm, Tora Ida Henriksen, Maria Pedersen, Bente Klarlund Pedersen, Camilla Scheele & Charlotte Ling, 2019 Jan 15, In: Stem Cell Research and Therapy. 10, 1, 26.

    Research output: Contribution to journalArticle

  20. Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

    Oliver Kluth, Mandy Stadion, Pascal Gottmann, Heja Aga, Markus Jähnert, Stephan Scherneck, Heike Vogel, Ulrika Krus, Anett Seelig, Charlotte Ling, Jantje Gerdes & Annette Schürmann, 2019, In: Cell Reports. 26, 11, p. 3027-3036.e3

    Research output: Contribution to journalArticle

  21. Epigenetics in Human Obesity and Type 2 Diabetes

    Charlotte Ling & Tina Rönn, 2019, In: Cell Metabolism. 29, 5, p. 1028-1044 17 p.

    Research output: Contribution to journalReview article

  22. Epigenome-wide association study of incident type 2 diabetes in a British population: EPIC-Norfolk study

    Alexia Cardona, Felix R. Day, John R.B. Perry, Marie Loh, Audrey Y. Chu, Benjamin Lehne, Dirk S. Paul, Luca A. Lotta, Isobel D. Stewart, Nicola D. Kerrison, Robert A. Scott, Kay Tee Khaw, Nita G. Forouhi, Claudia Langenberg, Chunyu Liu, Michael M. Mendelson, Daniel Levy, Stephan Beck, R. David Leslie, Josée Dupuis & 10 others, James B. Meigs, Jaspal S. Kooner, Jussi Pihlajamäki, Allan Vaag, Alexander Perfilyev, Charlotte Ling, Marie France Hivert, John C. Chambers, Nicholas J. Wareham & Ken K. Ong, 2019, In: Diabetes. 68, 12, p. 2315-2326 12 p.

    Research output: Contribution to journalArticle

  23. Fasting unmasks differential fat and muscle transcriptional regulation of metabolic gene sets in low versus normal birth weight men

    Linn Gillberg, Tina Rönn, Sine Wanda Jørgensen, Alexander Perfilyev, Line Hjort, Emma Nilsson, Charlotte Brøns, Allan Vaag & Charlotte Ling, 2019, In: EBioMedicine. 47, p. 341-351

    Research output: Contribution to journalArticle

  24. Insulin induces Thr484 phosphorylation and stabilization of SIK2 in adipocytes

    Johanna Säll, Florentina Negoita, Björn Hansson, Franziska Kopietz, Wilhelm Linder, Annie M L Pettersson, Mikael Ekelund, Jurga Laurencikiene, Eva Degerman, Karin G Stenkula & Olga Göransson, 2019, In: Cellular Signalling. 55, p. 73-80

    Research output: Contribution to journalArticle

  25. The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

    Marie Balslev Backe, Chunyu Jin, Luz Andreone, Aditya Sankar, Karl Agger, Kristian Helin, Andreas Nygaard Madsen, Steen Seier Poulsen, Madhusudhan Bysani, Karl Bacos, Charlotte Ling, Marcelo Javier Perone, Birgitte Holst & Thomas Mandrup-Poulsen, 2019, In: Journal of Diabetes Research. 2019, 5451038.

    Research output: Contribution to journalArticle

  26. 2018
  27. A Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary Syndrome

    Milana Kokosar, Anna Benrick, Alexander Perfilyev, Emma Nilsson, Thomas Källman, Claes Ohlsson, Charlotte Ling & Elisabet Stener-Victorin, 2018 Dec 1, In: Scientific Reports. 8, 1, 1878.

    Research output: Contribution to journalArticle

  28. Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children

    Line Hjort, David Martino, Louise Groth Grunnet, Haroon Naeem, Jovana Maksimovic, Anders Henrik Olsson, Cuilin Zhang, Charlotte Ling, Sjurdur Frodi Olsen, Richard Saffery & Allan Arthur Vaag, 2018 Sep 6, In: JCI Insight. 3, 17, e122572.

    Research output: Contribution to journalArticle

  29. Serum and gene expression levels of CT-1, IL-6, and TNF-α after a lifestyle intervention in obese children

    A. Marti, L. Morell-Azanza, T. Rendo-Urteaga, S. García-Calzón, A. Ojeda-Rodríguez, N. Martín-Calvo, M. J. Moreno-Aliaga, J. A. Martínez & M. C. Azcona-San Julián, 2018 Mar, In: Pediatric Diabetes. 19, 2, p. 217-222 6 p.

    Research output: Contribution to journalArticle

  30. DNA methylation patterns in human adipose tissue in relation to diet and type 2 diabetes

    Alexander Perfilyev, 2018, Lund: Lund University: Faculty of Medicine. 47 p.

    Research output: ThesisDoctoral Thesis (compilation)

  31. Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

    Marie Balslev Backe, Jan Legaard Andersson, Karl Bacos, Dan Ploug Christensen, Jakob Bondo Hansen, Jerzy Jòzef Dorosz, Michael Gajhede, Tina Dahlby, Madhusudhan Bysani, Line Hyltoft Kristensen, Charlotte Ling, Lars Olsen & Thomas Mandrup-Poulsen, 2018, In: Molecular and Cellular Endocrinology. 460, p. 47-56

    Research output: Contribution to journalArticle

  32. The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets

    Elin Hall, Marloes Dekker Nitert, Petr Volkov, Siri Malmgren, Hindrik Mulder, Karl Bacos & Charlotte Ling, 2018, In: Molecular and Cellular Endocrinology. 472, p. 57-67

    Research output: Contribution to journalArticle

  33. 2017
  34. Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

    Sonia García-Calzón, Alexander Perfilyev, Ville Männistö, Vanessa de Mello, Emma A Nilsson, Jussi Pihlajamäki & Charlotte Ling, 2017 Sep 21, In: Clinical Epigenetics. 9, 1, p. 1-9 102.

    Research output: Contribution to journalArticle

  35. 36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner

    Line Hjort, Sine W Jørgensen, Linn Gillberg, Elin Hall, Charlotte Brøns, Jan Frystyk, Allan A. Vaag & Charlotte Ling, 2017 Apr 21, In: Clinical Epigenetics. 9, 1, 40.

    Research output: Contribution to journalArticle

  36. Fetal hyperglycemia changes human preadipocyte function in adult life

    Ninna Schiøler Hansen, Klaudia Stanislawa Strasko, Line Hjort, Louise Kelstrup, Azadeh Houshmand-ØRegaard, Maren Schrölkamp, Heidi Schiøler Schultz, Camilla Scheele, Bente Klarlund Pedersen, Charlotte Ling, Tine Dalsgaard Clausen, Peter Damm, Allan Vaag & Christa Broholm, 2017 Apr 1, In: Journal of Clinical Endocrinology and Metabolism. 102, 4, p. 1141-1150 10 p.

    Research output: Contribution to journalArticle

  37. Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: A randomized controlled trial

    Alexander Perfilyev, Ingrid Dahlman, Linn Gillberg, Fredrik Rosqvist, David Iggman, Petr Volkov, Emma Nilsson, Ulf Risérus & Charlotte Ling, 2017 Apr 1, In: American Journal of Clinical Nutrition. 105, 4, p. 991-1000 10 p.

    Research output: Contribution to journalArticle

  38. Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver

    Madhusudhan Bysani, Alexander Perfilyev, Vanessa de Mello, Tina Rönn, Emma Nilsson, Jussi Pihlajamäki & Charlotte Ling, 2017 Feb 1, In: Epigenomics. 9, 2, p. 105-122 18 p.

    Research output: Contribution to journalArticle

  39. Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity

    Maria Keller, Lydia Hopp, Xuanshi Liu, Tobias Wohland, Kerstin Rohde, Raffaella Cancello, Matthias Klös, Karl Bacos, Matthias Kern, Fabian Eichelmann, Arne Dietrich, Michael R. Schön, Daniel Gärtner, Tobias Lohmann, Miriam Dreßler, Michael Stumvoll, Peter Kovacs, Anna Maria DiBlasio, Charlotte Ling, Hans Binder & 2 others, Matthias Blüher & Yvonne Böttcher, 2017 Jan 1, In: Molecular Metabolism. 6, 1, p. 86-100 15 p.

    Research output: Contribution to journalArticle

  40. Hepatic DPP4 DNA methylation associates with fatty liver

    Christian Baumeier, Sophie Saussenthaler, Anne Kammel, Markus Jähnert, Luisa Schlüter, Deike Hesse, Mickaël Canouil, Stephane Lobbens, Robert Caiazzo, Violeta Raverdy, François Pattou, Emma Nilsson, Jussi Pihlajamäki, Charlotte Ling, Philippe Froguel, Annette Schürmann & Robert W. Schwenk, 2017 Jan 1, In: Diabetes. 66, 1, p. 25-35 11 p.

    Research output: Contribution to journalArticle

  41. HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

    Mahboubeh Daneshpajooh, Karl Bacos, Madhusudhan Bysani, Annika Bagge, Emilia Ottosson Laakso, Petter Vikman, Lena Eliasson, Hindrik Mulder & Charlotte Ling, 2017 Jan, In: Diabetologia. 60, 1, p. 116–125

    Research output: Contribution to journalArticle

  42. Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action

    Vanessa de Mello, Ashok Matte, Alexander Perfilyev, Ville Männistö, Tina Rönn, Emma Nilsson, Pirjo Käkelä, Charlotte Ling & Jussi Pihlajamäki, 2017, In: Epigenetics. 12, 4, p. 287-295 9 p.

    Research output: Contribution to journalArticle

  43. Role of dietary pattern and obesity on telomere homeostasis

    Sonia García-Calzón & Amelia Marti Del Moral, 2017, Telomeres, Diet and Human Disease: Advances and Therapeutic Opportunities. CRC Press, p. 133-148

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  44. Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents

    Lydia Morell-Azanza, Sonia García-Calzón, Tara Rendo-Urteaga, Nerea Martin-Calvo, Maria Chueca, José Alfredo Martínez, Maria Cristina Azcona-Sanjulián & Amelia Marti, 2017, In: Pediatric Diabetes. 18, 5, p. 392-398

    Research output: Contribution to journalArticle

  45. 2016
  46. Human adipogenesis is associated with genome-wide DNA methylation and gene-expression changes

    Christa Broholm, Anders Henrik Olsson, Alexander Perfilyev, Linn Gillberg, Ninna Schiøler Hansen, Ashfaq Ali, Brynjulf Mortensen, Charlotte Ling & Allan Vaag, 2016 Dec 1, In: Epigenomics. 8, 12, p. 1601-1617 17 p.

    Research output: Contribution to journalArticle

  47. Epigenetic programming of adipose-derived stem cells in low birthweight individuals

    Christa Broholm, Anders H. Olsson, Alexander Perfilyev, Ninna S. Hansen, Maren Schrölkamp, Klaudia S. Strasko, Camilla Scheele, Rasmus Ribel-Madsen, Brynjulf Mortensen, Sine W. Jørgensen, Charlotte Ling & Allan Vaag, 2016 Dec, In: Diabetologia. 59, 12, p. 2664–2673 10 p.

    Research output: Contribution to journalArticle

  48. Epigenetic markers to further understand insulin resistance

    Charlotte Ling & Tina Rönn, 2016 Nov 1, In: Diabetologia. 59, 11, p. 2295-2297

    Research output: Contribution to journalDebate/Note/Editorial

  49. DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk

    Tasnim Dayeh, Tiinamaija Tuomi, Peter Almgren, Alexander Perfilyev, Per Anders Jansson, Vanessa D. de Mello, Jussi Pihlajamäki, Allan Vaag, Leif Groop, Emma Nilsson & Charlotte Ling, 2016 Jul 2, In: Epigenetics. 11, 7, p. 482-488 7 p.

    Research output: Contribution to journalArticle

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