Diabetes - Islet Patophysiology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Medical Genetics
  • Cell and Molecular Biology
  • Physiology

Keywords

  • Type 2 diabetes, nano, islet

Description

We are striving towards the identification of disease-modifying mechanisms that protect endogenous insulin release and diabetes development. Ion channels play overarching roles as sensors of cellular activity and control long-term adaptation of the endocrine pancreatic islet to the environmental demands. Our goals concern signals involved in cellular responses to beta-cell overload: 1)Role of voltage-gated Ca2+ channel subunits and Ca2+ signals for beta-cell gene expression, differentiation status, secretory capacity and diabetes 2)Role of non-voltage-gated ion channels and ligands and mechanical signals for beta-cell gene expression, differentiation status, secretory capacity and diabetes. Novel therapeutic approaches: Superparamagnetic nanoparticles as tools for targeted receptor activation and triggering of mechanosensing

Recent research outputs

Enming Zhang, Israa Mohammed, Mohammed, S., Cheng Luan, Olof Asplund, Ahmed, M., Ye Yingying, Ben-Hail, D., Soni, A., Vishnu, N., Bompada Pradeep, Yang de Marinis, Leif Groop, Shoshan-Barmatz, V., Erik Renström, Claes Wollheim & S Albert Salehi, 2019 Jan 8, In : Cell Metabolism. 29, 1, p. 64-77.e6

Research output: Contribution to journalArticle

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