Diabetes - Molecular Metabolism

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Nutrition and Dietetics
  • Medical Genetics
  • Cell and Molecular Biology

Keywords

  • Type 2 diabetes, insulin, T2D

Description

The overall goal of our research unit is to understand metabolic control of insulin secretion and why it fails in type 2 diabetes (T2D). In recent years, this has meant that we have used information from GWAS (Genome-wide association study) to direct our efforts towards the genes which are actually linked to the development of the disease. To reach this overarching goal, we have worked along two lines: 1) mitochondrial (dys)function in ß-cells and, 2) melatonin signaling in islets. In fact, these projects have emanated from findings in GWAS, where genetic variants of Transcription factor B1 mitochondrial (TFB1M) and the Melatonin receptor 1B have been robustly associated with T2D. Overall, our work holds promise to increase understanding of how T2D evolves. Mitochondrial function is difficult to target with drugs. In contrast, the melatonin receptor 1B is a potential drug target in T2D.

Recent research outputs

Peter Spégel & Hindrik Mulder, 2019 Jul 17, In : Journal of Molecular Biology.

Research output: Contribution to journalReview article

Tania Singh, Colberg, J. K., Luis Sarmiento, Chaves, P., Hansen, L., Bsharat, S., Luis R. Cataldo, Monika Dudenhöffer-Pfeifer, Malin Fex, David Bryder, Dan Holmberg, Ewa Sitnicka, Corrado Cilio, Rashmi B. Prasad & Isabella Artner, 2019 Jun 24, In : Scientific Reports. 9, 1, 9074.

Research output: Contribution to journalArticle

Enming Zhang, Israa Mohammed, Mohammed, S., Cheng Luan, Olof Asplund, Ahmed, M., Ye Yingying, Ben-Hail, D., Soni, A., Vishnu, N., Bompada Pradeep, Yang de Marinis, Leif Groop, Shoshan-Barmatz, V., Erik Renström, Claes Wollheim & S Albert Salehi, 2019 Jan 8, In : Cell Metabolism. 29, 1, p. 64-77.e6

Research output: Contribution to journalArticle

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