Diabetes - Molecular Metabolism

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  1. 2019
  2. Metabolomics Analysis of Nutrient Metabolism in β-Cells

    Peter Spégel & Hindrik Mulder, 2019 Jul 17, In : Journal of Molecular Biology.

    Research output: Contribution to journalReview article

  3. Loss of MafA and MafB expression promotes islet inflammation.

    Tania Singh, Colberg, J. K., Luis Sarmiento, Chaves, P., Hansen, L., Bsharat, S., Luis R. Cataldo, Monika Dudenhöffer-Pfeifer, Malin Fex, David Bryder, Dan Holmberg, Ewa Sitnicka, Corrado Cilio, Rashmi B. Prasad & Isabella Artner, 2019 Jun 24, In : Scientific Reports. 9, 1, 9074.

    Research output: Contribution to journalArticle

  4. Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells

    Enming Zhang, Israa Mohammed, Mohammed, S., Cheng Luan, Olof Asplund, Ahmed, M., Ye Yingying, Ben-Hail, D., Soni, A., Vishnu, N., Bompada Pradeep, Yang de Marinis, Leif Groop, Shoshan-Barmatz, V., Erik Renström, Claes Wollheim & S Albert Salehi, 2019 Jan 8, In : Cell Metabolism. 29, 1, p. 64-77.e6

    Research output: Contribution to journalArticle

  5. Serotonergic Regulation of Insulin Secretion

    Luis Rodrigo Cataldo Bascuñan, Claire Lyons, Bennet, H., Isabella Artner & Malin Fex, 2019 Jan, In : Acta Physiologica. 225, 1, e13101.

    Research output: Contribution to journalReview article

  6. Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

    Knudsen, J. G., Alexander Hamilton, Ramracheya, R., Tarasov, A. I., Brereton, M., Haythorne, E., Chibalina, M. V., Peter Spégel, Hindrik Mulder, Zhang, Q., Ashcroft, F. M., Adam, J. & Rorsman, P., 2019, In : Cell Metabolism. 29, 2, p. 430-442.e4

    Research output: Contribution to journalArticle

  7. Platelet Serotonin Levels Are Associated with Plasma Soluble Leptin Receptor Concentrations in Normoglycemic Women

    Rodrigo Cataldo Buscunan, Suazo, J., Olmos, P., Bravo, C., Galgani, J. E., Malin Fex, Martínez, J. A. & Santos, J. L., 2019, In : Journal of Diabetes Research. 2019, 11 p., 2714049.

    Research output: Contribution to journalArticle

  8. 2018
  9. Population-Level Analysis to Determine Parameters That Drive Variation in the Plasma Metabolite Profiles

    Al-Majdoub, M., Katharina Herzog, Daka, B., Martin Magnusson, Lennart Råstam, Lindblad, U. & Peter Spégel, 2018 Nov 15, In : Metabolites. 8, 4, 78.

    Research output: Contribution to journalArticle

  10. Nutritional modulation of AMPK-impact upon metabolic-inflammation

    Claire L. Lyons & Roche, H. M., 2018 Oct 9, In : International Journal of Molecular Sciences. 19, 10, 3092.

    Research output: Contribution to journalReview article

  11. Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial

    Safai, N., Suvitaival, T., Ali, A., P. Spégel, Al-Majdoub, M., Carstensen, B., Vestergaard, H. & M. Ridderstråle, 2018 Jul, In : Diabetic Medicine. 35, 7, p. 944-953

    Research output: Contribution to journalArticle

  12. The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization

    Lindström, L., Li, T., Malycheva, D., Kancharla, A., Helén Nilsson, Neelanjan Vishnu, Hindrik Mulder, Martin Johansson, Rosselló, C. A. & Maria Alvarado-Kristensson, 2018 May 3, In : Communications Biology. 1, https://doi.org/10.1038/s42003-018-0037-3, 37.

    Research output: Contribution to journalArticle

  13. Novel subgroups of adult-onset diabetes and their association with outcomes: A data-driven cluster analysis of six variables

    Ahlqvist, E., Storm, P., Käräjämäki, A., Martinell, M., Dorkhan, M., Carlsson, A., Vikman, P., Prasad, R. B., Aly, D. M., Almgren, P., Wessman, Y., Shaat, N., Spégel, P., Mulder, H., Lindholm, E., Melander, O., Hansson, O., Malmqvist, U., Lernmark, Å., Lahti, K. & 4 othersForsén, T., Tuomi, T., Anders H. Rosengren & Leif Groop, 2018 May, In : The Lancet Diabetes and Endocrinology. 6, 5, p. 361-369

    Research output: Contribution to journalArticle

  14. Glutamine-elicited secretion of glucagon-like peptide 1 is governed by an activated glutamate dehydrogenase

    Andersson, L. E., Liliya Shcherbina, Al-Majdoub, M., Neelanjan Vishnu, Arroyo, C. B., Carrara, J. A., Claes B. Wollheim, Malin Fex, Hindrik Mulder, Nils Wierup & Peter Spégel, 2018 Mar 1, In : Diabetes. 67, 3, p. 372-384 13 p.

    Research output: Contribution to journalArticle

  15. Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats

    Medina, A., Parween, S., Ullsten, S., Neelanjan Vishnu, Siu, Y. T., Quach, M., Bennet, H., Balhuizen, A., Åkesson, L., Nils Wierup, Carlsson, P. O., Ahlgren, U., Åke Lernmark & Malin Fex, 2018, In : Diabetologia. 61, 4, p. 896-905

    Research output: Contribution to journalArticle

  16. The pathogenetic role of β-cell mitochondria in type 2 diabetes

    Malin Fex, Nicholas, L. M., Neelanjan Vishnu, Medina, A., Sharoyko, V. V., David G. Nicholls, Peter Spégel & Hindrik Mulder, 2018, In : Journal of Endocrinology. 236, 3, p. R145-R149

    Research output: Contribution to journalReview article

  17. 2017
  18. Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

    Adam, J., Ramracheya, R., Chibalina, M. V., Ternette, N., Hamilton, A., Tarasov, A. I., Zhang, Q., Rebelato, E., Rorsman, N. J. G., Martín-del-Río, R., Lewis, A., Özkan, G., Do, H. W., Spégel, P., Saitoh, K., Kato, K., Igarashi, K., Kessler, B. M., Pugh, C. W., Tamarit-Rodriguez, J. & 8 othersHindrik Mulder, Clark, A., Frizzell, N., Soga, T., Ashcroft, F. M., Silver, A., Pollard, P. J. & Rorsman, P., 2017 Sep 26, In : Cell Reports. 20, 13, p. 3135-3148 14 p.

    Research output: Contribution to journalArticle

  19. Metabolite profiling of obese individuals before and after a one year weight loss program

    Geidenstam, N., Al-Majdoub, M., M. Ekman, P. Spégel & M. Ridderstråle, 2017 Sep 1, In : International Journal of Obesity. 41, 9, p. 1369-1378 10 p.

    Research output: Contribution to journalArticle

  20. Regulation of Nuclear Receptor Interacting Protein 1 (NRIP1) Gene Expression in Response to Weight Loss and Exercise in Humans

    Yang De Marinis, Jiangming Sun, Pradeep Bompada, Domènech Omella, J., Cheng Luan, Halu, A., Erik Renström, Sharma, A. & Martin Ridderstråle, 2017 Aug 1, In : Obesity. 25, 8, p. 1400-1409 10 p.

    Research output: Contribution to journalArticle

  21. Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells

    Nicholas, L. M., Valtat, B., Benavente, A. M., Andersson, L., Abels, M., Mollet, I., Jain, D., Lena Eliasson, Nils Wierup, Malin Fex & Hindrik Mulder, 2017 Jul, In : Molecular Metabolism. 6, 7, p. 651-663 13 p.

    Research output: Contribution to journalArticle

  22. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

    Axelsson, A. S., Tubbs, E., Mecham, B., Chacko, S., Nenonen, H. A., Tang, Y., Fahey, J. W., Derry, J. M. J., Claes B. Wollheim, Nils Wierup, Haymond, M. W., Friend, S. H., Hindrik Mulder & Anders H. Rosengren, 2017 Jun 14, In : Science Translational Medicine. 9, 394, 4477.

    Research output: Contribution to journalArticle

  23. Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes

    Axelsson, A., Mahdi, T., Nenonen, H. A., Singh, T., Hänzelmann, S., Wendt, A., Bagge, A., Reinbothe, T. M., Millstein, J., Yang, X., Zhang, B., Gusmao, E. G., Shu, L., Szabat, M., Tang, Y., Wang, J., Salö, S., Eliasson, L., Artner, I., Fex, M. & 9 othersJ D Johnson, C B Wollheim, Derry, J. M. J., Mecham, B., P Spégel, H Mulder, Costa, I. G., E Zhang & Rosengren, A. H., 2017 Jun 6, In : Nature Communications. 8, p. 15652

    Research output: Contribution to journalArticle

  24. NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

    Santos, L. R. B., Muller, C., de Souza, A. H., Takahashi, H. K., Peter Spégel, Sweet, I. R., Chae, H., Hindrik Mulder & Jonas, J. C., 2017 Jun, In : Molecular Metabolism. 6, 6, p. 535-547 13 p.

    Research output: Contribution to journalArticle

  25. Bioenergetic Impairment in Congenital Muscular Dystrophy Type 1A and Leigh Syndrome Muscle Cells

    Fontes-Oliveira, C. C., Steinz, M., Schneiderat, P., Hindrik Mulder & Madeleine Durbeej, 2017 Apr 3, In : Scientific Reports. 7, 45272.

    Research output: Contribution to journalArticle

  26. Metabolite profiling of LADA challenges the view of a metabolically distinct subtype

    Al-Majdoub, M., Ali, A., Storm, P., Anders H. Rosengren, Leif Groop & Peter Spégel, 2017 Apr 1, In : Diabetes. 66, 4, p. 806-814 9 p.

    Research output: Contribution to journalArticle

  27. Characterization of resident lymphocytes in human pancreatic islets

    Radenkovic, M., Uvebrant, K., Skog, O., Luis Sarmiento-Pérez, Avartsson, J., Storm, P., Vickman, P., Bertilsson, P. A., M. Fex, Korgsgren, O. & C. M. Cilio, 2017 Mar 1, In : Clinical and Experimental Immunology. 187, 3, p. 418-427 10 p.

    Research output: Contribution to journalArticle

  28. HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

    Daneshpajooh, M., Karl Bacos, Bysani, M., Bagge, A., Ottosson Laakso, E., Petter Vikman, Lena Eliasson, Hindrik Mulder & Charlotte Ling, 2017 Jan, In : Diabetologia. 60, 1, p. 116–125

    Research output: Contribution to journalArticle

  29. Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss

    Geidenstam, N., Martin Magnusson, Danielsson, A. P. H., Gerszten, R. E., Wang, T. J., Reinius, L. E., Hindrik Mulder, Olle Melander & Martin Ridderstråle, 2017, In : International Journal of Endocrinology. 2017, 6490473.

    Research output: Contribution to journalArticle

  30. Branched-chain amino acids are associated with odd-chain fatty acids in normoglycaemic individuals

    Al-Majdoub, M., Geidenstam, N., Ali, A., M. Ridderstråle, Storm, P., L. Groop, Louise Bennet & P. Spégel, 2017, In : Diabetes & Metabolism. 43, 5, p. 475-479

    Research output: Contribution to journalLetter

  31. Cartilage oligomeric matrix protein promotes prostate cancer progression by enhancing invasion and disrupting intracellular calcium homeostasis

    Emelie Englund, Canesin, G., Konstantinos S. Papadakos, Neelanjan Vishnu, Persson, E., Reitsma, B., Aseem Anand, Jacobsson, L., Helczynski, L., Hindrik Mulder, Anders Bjartell & Anna M. Blom, 2017, In : Oncotarget. 8, 58, p. 98298-98311 14 p.

    Research output: Contribution to journalArticle

  32. Transcribing β-cell mitochondria in health and disease

    Hindrik Mulder, 2017, In : Molecular Metabolism. 6, 9, p. 1040-1051

    Research output: Contribution to journalReview article

  33. 2016
  34. Glycogen metabolism in the glucose-sensing and supply-driven β-cell

    Andersson, L. E., Nicholas, L. M., Karin Filipsson, Jiangming Sun, Benavente, A. M., Al-Majdoub, M., Malin Fex, Hindrik Mulder & Peter Spégel, 2016 Dec 1, In : FEBS Letters. 590, 23, p. 4242-4251 10 p.

    Research output: Contribution to journalLetter

  35. Metabolic coupling in pancreatic beta cells: lipolysis revisited

    Hindrik Mulder, 2016 Dec 1, In : Diabetologia. 59, 12, p. 2510–2513 4 p.

    Research output: Contribution to journalArticle

  36. Discriminative prediction of A-To-I RNA editing events from DNA sequence

    Jiangming Sun, Yang De Marinis, Osmark, P., Singh, P., Bagge, A., Valtat, B., Petter Vikman, Peter Spégel & Hindrik Mulder, 2016 Oct 1, In : PLoS ONE. 11, 10, e0164962.

    Research output: Contribution to journalArticle

  37. Influence of a HTR2B stop codon on glucagon homeostasis and glucose excursion in non-diabetic men

    Tikkanen, R., Saukkonen, T., M. Fex, Bennet, H., Rautiainen, M. R., Paunio, T., Koskinen, M., Panarsky, R., Bevilacqua, L., Sjöberg, R. L., Tiihonen, J. & Virkkunen, M., 2016 Oct 1, In : Experimental and Clinical Endocrinology & Diabetes. 124, 9, p. 529-534 6 p.

    Research output: Contribution to journalArticle

  38. The pancreatic β-cell: A bioenergetic perspective

    David G. Nicholls, 2016 Oct 1, In : Physiological Reviews. 96, 4, p. 1385-1447 63 p.

    Research output: Contribution to journalArticle

  39. Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

    Tuomi, T., Nagorny, C. L. F., Singh, P., Bennet, H., Yu, Q., Alenkvist, I., Isomaa, B., Östman, B., Söderström, J., Pesonen, A. K., Martikainen, S., Räikkönen, K., Forsén, T., Hakaste, L., Almgren, P., Storm, P., Asplund, O., Shcherbina, L., Fex, M., Fadista, J. & 4 othersTengholm, A., Nils Wierup, Leif Groop & Hindrik Mulder, 2016 Jun 14, In : Cell Metabolism. 23, 6, p. 1067-1077 11 p.

    Research output: Contribution to journalArticle

  40. Serotonin (5-HT) and 5-HT2A receptor agonists suppress lipolysis in primary rat adipose cells

    Björn Hansson, Benavente, A. M., Fryklund, C., Malin Fex & Karin G. Stenkula, 2016 May 27, In : Biochemical and Biophysical Research Communications. 474, 2, p. 357-363 7 p.

    Research output: Contribution to journalArticle

  41. Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer

    E Englund, M Bartoschek, Reitsma, B., Jacobsson, L., Escudero-Esparza, A., Orimo, A., K Leandersson, C Hagerling, A Aspberg, Storm, P., Okroj, M., H Mulder, K Jirström, K Pietras & A M Blom, 2016, In : Oncogene. 35, 43, p. 5585-5596 12 p.

    Research output: Contribution to journalArticle

  42. Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

    Bennet, H., Mollet, I., Balhuizen, A., Medina Benavente, A., Nagorny, C., Bagge, A., Fadista, J., Ottosson Laakso, E., Petter Vikman, Dekker Nitert, M., Lena Eliasson, Nils Wierup, Isabella Artner & Malin Fex, 2016, In : Diabetologia. 59, 4, p. 744-754

    Research output: Contribution to journalArticle

  43. 2015
  44. The Human Diabetes Proteome Project (HDPP): The 2014 update

    Schvartz, D., Bergsten, P., Baek, K. H., De La Rosa, A. B., Cantley, J., Dayon, L., Finamore, F., Fontana, P., Gaudet, P., Goo, Y. A., Moulder, R., Goodlett, D. R., Johnson, J. D., Konvalinka, A., Mulder, H., Priego-Capote, F., Sechi, S., Snyder, K. M., Tiss, A., Wiederkehr, A. & 3 othersXenarios, I., Kussmann, M. & J. C. Sanchez, 2015 Dec 1, In : Translational Proteomics. 8-9, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  45. Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.

    Bennet, H., Balhuizen, A., Medina Benavente, A., Dekker Nitert, M., Ottosson Laakso, E., Essén, S., Peter Spégel, Storm, P., Krus, U., Nils Wierup & Malin Fex, 2015, In : Peptides. 71, p. 113-120

    Research output: Contribution to journalArticle

  46. Calcium Modulation of Exocytosis-Linked Plasma Membrane Potential Oscillations in INS-1 832/13 Cells.

    Gerencser, A. A., Hindrik Mulder & Nicholls, D. G., 2015, In : Biochemical Journal. 471, 1, p. 111-122

    Research output: Contribution to journalArticle

  47. Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line.

    Andersson, L., Valtat, B., Bagge, A., Sharoyko, V., David Nicholls, Ravassard, P., Scharfmann, R., Peter Spégel & Hindrik Mulder, 2015, In : PLoS ONE. 10, 3, e0120879.

    Research output: Contribution to journalArticle

  48. High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling

    Daskoulidou, N., Zeng, B., Lisa Berglund, Jiang, H., Chen, G-L., Olga Kotova, Bhandari, S., Ayoola, J., Griffin, S., Atkin, S. L., Maria Gomez & Xu, S-Z., 2015, In : Journal of Molecular Medicine. 93, 5, p. 511-521

    Research output: Contribution to journalArticle

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